Chip-based liver equivalents for toxicity testing - organotypicalness versus cost-efficient high throughput [PDF]
, 2013 Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence
Marx, Uwe +2 more
core +1 more source
Microphysiological systems to study colorectal cancer: State-of-the-art [PDF]
, 2023 Colorectal cancer (CRC) still has a high prevalence of mortality in the world. So far, basic pre-clinical research based on 2D cultures has failed to improve patient prognostic outcomes.
Carvalho, Mariana Rodrigues +7 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Physiome-on-a-Chip: The Challenge of “Scaling” in Design, Operation, and Translation of Microphysiological Systems [PDF]
, 2015 Scaling of a microphysiological system (MPS) or physiome-on-a-chip is arguably two interrelated, modeling-based activities: on-platform scaling and in vitro-in vivo translation.
Cirit, Murat +2 more
core +1 more source
Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development [PDF]
, 2023 The National Center for Advancing Translational Sciences (NCATS) Assay Guidance Manual (AGM) Workshop on 3D Tissue Models for Antiviral Drug Development, held virtually on 7-8 June 2022, provided comprehensive coverage of critical concepts intended to ...
Alarcon, Rodolfo M +27 more
core +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
In Vitro Immune Organs-on-Chip for Drug Development: A Review
Pharmaceutics, 2018 The current drug development practice lacks reliable and sensitive techniques to evaluate the immunotoxicity of drug candidates, i.e., their effect on the human immune system.
Aya Shanti, Jeremy Teo, Cesare Stefanini
doaj +1 more source
Evolution of Biochip Technology: A Review from Lab-on-a-Chip to Organ-on-a-Chip
Micromachines, 2020 Following the advancements in microfluidics and lab-on-a-chip (LOC) technologies, a novel biomedical application for microfluidic based devices has emerged in recent years and microengineered cell culture platforms have been created. These micro-devices,
Neda Azizipour +4 more
doaj +1 more source
Application of the Virtual Cell Based Assay for Simulation of in vitro Chemical fate following Acute Exposure [PDF]
, 2017 In order to reliably assess the risk of adverse systemic effects of chemicals by using in vitro methods, there is a need to simulate their absorption, distribution, metabolism, and excretion (ADME) in vivo to determine the target organ bioavailable ...
BERGGREN ELISABET +6 more
core +1 more source