Results 11 to 20 of about 718 (167)
Frontiers in Pharmacology, 2023 The inefficiency of existing animal models to precisely predict human pharmacological effects is the root reason for drug development failure. Microphysiological system/organ-on-a-chip technology (organ-on-a-chip platform) is a microfluidic device ...
Naina Sunildutt +4 more
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Three-Dimensional-Bioprinted Liver Chips and Challenges
Applied Sciences, 2022 Drug testing, either on animals or on 2D cell cultures, has its limitations due to inaccurate mimicking of human pathophysiology. The liver, as one of the key organs that filters and detoxifies the blood, is susceptible to drug-induced injuries ...
Sajjad Rahmani Dabbagh +3 more
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Real-time monitoring of oxygen levels within thermoplastic Organ-on-Chip devices
Biosensors and Bioelectronics: X, 2022 Organ-on-chip (OOC) systems involve culturing of biological tissues within dynamic and controlled microenvironments, in order to mimic as closely as possible, in vivo conditions.
Anubhav Bussooa +6 more
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Biomimetic epithelium/endothelium on chips
Engineered Regeneration, 2022 Epithelium and endothelium, occupying a significant proportion of cells in the human body, play a crucial role in maintaining organs’ normal structure and function.
Lina Lin +6 more
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Gut-on-a-chip for disease models
Journal of Tissue Engineering, 2023 The intestinal tract is a vital organ responsible for digestion and absorption in the human body and plays an essential role in pathogen invasion. Compared with other traditional models, gut-on-a-chip has many unique advantages, and thereby, it can be ...
Changxiu Xian +3 more
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Haploinsufficiency of the E3 ubiquitin ligase C-terminus of heat shock cognate 70 interacting protein (CHIP) produces specific behavioral impairments. [PDF]
PLoS ONE, 2012 The multifunctional E3 ubiquitin ligase CHIP is an essential interacting partner of HSP70, which together promote the proteasomal degradation of client proteins.
Bethann McLaughlin +5 more
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Microfabrication of Embedding a Flexible Parylene-Based Microelectrode Array within Body-on-a-Chip
Proceedings, 2017 To study drug response on human heart cells and predict drug induced cardiotoxicity, a microfluidic cell culture device with an integrated microelectrode array (MEA) is a promising approach.
Tatsuya Omaki +4 more
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Towards Multi-Organoid Systems for Drug Screening Applications
Bioengineering, 2018 A low percentage of novel drug candidates succeed and reach the end of the drug discovery pipeline, mainly due to poor initial screening and assessment of the effects of the drug and its metabolites over various tissues in the human body.
Cláudia C. Miranda +3 more
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Engineered Vasculature for Organ-on-a-Chip Systems
Engineering, 2022 Organ-on-a-chip technology, a promising three-dimensional (3D) dynamic culture method, ensures accurate and efficient cell culture and has great potential for replacing animal models in preclinical testing. The circulatory system, the most abundant organ
Abdellah Aazmi +8 more
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Automatic Detection of Chip Pin Defect in Semiconductor Assembly Using Vision Measurement
Measurement Science Review, 2022 With the development of semiconductor assembly technology, the continuous requirement for the improvement of chip quality caused an increasing pressure on the assembly manufacturing process.
Lu Shengfang +3 more
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