Results 11 to 20 of about 133,256 (260)
The body-on-a-chip concept: possibilities and limitations [PDF]
EXCLI J, 2014 Reif, Raymond
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Frontiers in Pharmacology, 2023 The inefficiency of existing animal models to precisely predict human pharmacological effects is the root reason for drug development failure. Microphysiological system/organ-on-a-chip technology (organ-on-a-chip platform) is a microfluidic device ...
Naina Sunildutt +4 more
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Three-Dimensional-Bioprinted Liver Chips and Challenges
Applied Sciences, 2022 Drug testing, either on animals or on 2D cell cultures, has its limitations due to inaccurate mimicking of human pathophysiology. The liver, as one of the key organs that filters and detoxifies the blood, is susceptible to drug-induced injuries ...
Sajjad Rahmani Dabbagh +3 more
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Real-time monitoring of oxygen levels within thermoplastic Organ-on-Chip devices
Biosensors and Bioelectronics: X, 2022 Organ-on-chip (OOC) systems involve culturing of biological tissues within dynamic and controlled microenvironments, in order to mimic as closely as possible, in vivo conditions.
Anubhav Bussooa +6 more
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Biomimetic epithelium/endothelium on chips
Engineered Regeneration, 2022 Epithelium and endothelium, occupying a significant proportion of cells in the human body, play a crucial role in maintaining organs’ normal structure and function.
Lina Lin +6 more
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A microfluidic chip based model for the study of full thickness human intestinal tissue using dual flow [PDF]
, 2016 © 2016 Author(s). The study of inflammatory bowel disease, including Ulcerative Colitis and Crohn's Disease, has relied largely upon the use of animal or cell culture models; neither of which can represent all aspects of the human pathophysiology ...
A. Dawson +11 more
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Gut-on-a-chip for disease models
Journal of Tissue Engineering, 2023 The intestinal tract is a vital organ responsible for digestion and absorption in the human body and plays an essential role in pathogen invasion. Compared with other traditional models, gut-on-a-chip has many unique advantages, and thereby, it can be ...
Changxiu Xian +3 more
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Effects of Spaceflight on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function. [PDF]
, 2019 With extended stays aboard the International Space Station (ISS) becoming commonplace, there is a need to better understand the effects of microgravity on cardiac function. We utilized human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
Agrawal +30 more
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Haploinsufficiency of the E3 ubiquitin ligase C-terminus of heat shock cognate 70 interacting protein (CHIP) produces specific behavioral impairments. [PDF]
PLoS ONE, 2012 The multifunctional E3 ubiquitin ligase CHIP is an essential interacting partner of HSP70, which together promote the proteasomal degradation of client proteins.
Bethann McLaughlin +5 more
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Mechano-transduction: from molecules to tissues. [PDF]
, 2014 External forces play complex roles in cell organization, fate, and homeostasis. Changes in these forces, or how cells respond to them, can result in abnormal embryonic development and diseases in adults.
Dunn, Alexander R +3 more
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