Results 71 to 80 of about 76,436 (252)

Bone defect animal models for testing efficacy of bone substitute biomaterials

Journal of Orthopaedic Translation, 2015
Large bone defects are serious complications that are most commonly caused by extensive trauma, tumour, infection, or congenital musculoskeletal disorders.
Ye Li, Shu-Kui Chen, Long Li, Ling Qin, Xin-Luan Wang, Yu-Xiao Lai   +5 more
doaj   +1 more source

Fabrication of Aligned Polycaprolactone Nanofibrillar Bundles to Control Cell‐Mediated Collagen Deposition in Engineered Cartilage

Advanced Materials, EarlyView.
Melt electrofibrillation (MEF) enables the fabrication of nanofibrillar PCL scaffolds with defined architectures that guide cellular alignment and retention during cartilage tissue engineering. Unlike conventional melt electrowriting, MEF consistently directs collagen type II‐rich extracellular matrix organization, providing a tunable platform to ...
Alba Pueyo Moliner, Lennard Spauwen, James L. Martin Robinson, Ángela García Grech, Isabelle Martinier, Sara Grasselli, Aylin Kara Özenler, Matthias Ryma, Jürgen Groll, Mylène de Ruijter, Jos Malda   +10 more
wiley   +1 more source

Dual-functional biomimetic periosteum incorporating engineered small extracellular vesicles for treating critical bone defect with soft tissue fenestration via TGF-beta1/SMAD pathway

Materials Today Bio
Critical bone defect with soft tissue fenestration poses a significant therapeutic challenge without the premise of barrier periosteum in situ for the relatively independent repair spaces of soft tissue and bone. Inspired by the regenerative functions of
Zhengchuan Zhang, Jiaqi Shen, Ruogu Xu, Yang Yang, Xiaolin Yu, Dongsheng Yu, Feilong Deng   +6 more
doaj   +1 more source

A Critical Call for Mechanistic Investigations of Metal‐Bacteria Interactions

Advanced Materials, EarlyView.
It is well established that the antibacterial properties of metals have tremendous importance for bioengineering applications. What is not as appreciated, however, is the reproducibility crisis in this field's vast literature. In this perspective, we highlight this reproducibility problem, discuss its sources, and suggest solutions towards focused ...
J. Rackwitz, A. Bandyopadhyay, S. Belkin, S. Bose, N. Eliaz, J. L. Gilbert, T. C. Lowe, F. Mücklich, R. J. Turner, C. C. Tasan   +9 more
wiley   +1 more source

Study of the repair of femoral bone defects using adipose-derived stem cells (ADSCs) on Chitosan - Gelatin membrane in rats (biomechanical and radiological evaluations)

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2015
Background and purpose: Adipose - drived stem cells are multipotent cells that capable to diffrentiate in to osteogenic cells. On the other hand, the scaffold of chitosan and gelatin are biodegradable and compatible used for tissue repair.
S Salehy shemiran, M Sadooghi, H Sadraie, GR Kaka   +3 more
doaj  

Graphene Layers as Functional Biomaterials. From Fabrication and Characterization to Biological Applications

Advanced Materials Interfaces, EarlyView.
Graphene layers are fabricated on Cu foil and transferred onto glass substrates to form double‐ and multi‐layer G‐glass. Raman spectroscopy confirms structural integrity, while SEM and fluorescence microscopy reveal favorable adhesion and spreading of L‐929 fibroblast cells.
Mariana Mihaela Apostol, Issam Boukhoubza, Daniela Oprea, Iulia Corina Ciobotaru, Catalin Negrila, Ionut Enculescu, Ecaterina Andronescu, Teodor Adrian Enache, Elena Matei   +8 more
wiley   +1 more source

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

Biofunctionalisation strategies of material surface and the inspired biological effects for bone repair

Biosurface and Biotribology
Due to trauma and disease, bone defects endanger the healthy life of human beings. At present, the gold standard for bone defect repair is still autologous bone transplantation and allogeneic bone transplantation.
Guowen Duan, Dongbiao Chang, Chengdong Zhang, Siyu Li, Xinyao Liu, Zian Wang, Long Chen, Jinsheng Li, Zhenfan Bai, Jie Weng   +9 more
doaj   +1 more source

Hybrid Additive Manufacturing of Highly Stretchable Bottlebrush Polymer Nanocomposites by Decoupled Extrusion and Photopatterning

Advanced Materials Technologies, EarlyView.
A Hybrid Direct Ink Writing–Digital Light Processing (HDD) strategy decouples material extrusion from shape definition, enabling high‐fidelity additive manufacturing of highly viscous, yield‐stress polymer nanocomposites. Excess ink acts as a removable, self‐supporting scaffold, allowing fabrication of unsupported and embedded complex architectures ...
Shahryar Ramezani Bajgiran, Emmanuel Oduro, Daniel A. Rau, Li‐Heng Cai   +3 more
wiley   +1 more source

Effect of SDF-1 with biphasic ceramic-like bone graft on the repair of rabbit radial defect

Journal of Orthopaedic Surgery and Research, 2019
Background This study aimed to investigate the effects of stromal cell-derived factor-1 (SDF-1) on biphasic ceramic-like biologic bone (BCBB) in vivo on the repair of large segment bone defect in rabbits.
Fuke Wang, Guiran Yang, Yu Xiao, Chuan He, Guofeng Cai, En Song, Yanlin Li   +6 more
doaj   +1 more source