Results 81 to 90 of about 1,355,503 (353)
Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass. [PDF]
, 2012 Aging reduces the number of mesenchymal stem cells (MSCs) that can differentiate into osteoblasts in the bone marrow, which leads to impairment of osteogenesis.
Guan, Min +11 more
core +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Effects of Super-Activated Platelet Lysate on Early Healing of Tooth Extraction Sockets in Rats
Drug Design, Development and Therapy, 2022 Xiaorui Guo,1,2 Huiying Lu,3 Chunxiang Liu,3 Yi Zhang,3 Liangjia Bi1 1Department of Stomatology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, 150001, People’s Republic of China; 2State Key Laboratory of Military Stomatology and ...
Guo X, Lu H, Liu C, Zhang Y, Bi L
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The unbearable lightness of bone marrow homeostasis [PDF]
, 2015 The anatomical and functional dimensions of bone marrow topography have been at the forefront of modern bone and immunological research for many years and remain a source of complexity and perplexity due to the multitude of microhabitats within this ...
AGAS, DIMITRIOS +3 more
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
The temporal response of bone to unloading [PDF]
Rats were suspended by their tails with the forelimbs bearing the weight load to simulate the weightlessness of space flight. Growth in bone mass ceased by 1 week in the hindlimbs and lumbar vertebrae in growing rats, while growth in the forelimbs and ...
Bikle, D. D. +2 more
core +1 more source
Effect of sonic hedgehog/β-TCP composites on bone healing within the critical-sized rat femoral defect [PDF]
, 2013 The creation of entirely synthetically derived bone substitute materials which are as effective as autologous bone grafts is desirable. Osteogenesis involves the concerted action of several proteins within a signaling cascade.
Flinspach, Armin Niklas +5 more
core +1 more source
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Temperature responsiveness of gilthead sea bream bone; an in vitro and in vivo approach [PDF]
, 2018 This study aimed to characterize the molecules involved in osteogenesis in seabream and establish using in vitro/in vivo approaches the responsiveness of selected key genes to temperature.
Capilla, Encarnacion +8 more
core +3 more sources
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source