Results 11 to 20 of about 381,513 (352)

Tumor-targeting Salmonella typhimurium A1-R inhibits human prostate cancer experimental bone metastasis in mouse models. [PDF]

, 2015
Bone metastasis is a frequent occurrence in prostate cancer patients and often is lethal. Zoledronic acid (ZOL) is often used for bone metastasis with limited efficacy.
Bouvet, Michael, Hoffman, Robert M, Hu, Cameron, Matsumoto, Yasunori, Miwa, Shinji, Nakanishi, Hayao, Toneri, Makoto, Yano, Shuya, Zhang, Yong, Zhao, Ming   +9 more
core   +6 more sources

Insights into immuno-oncology drug development landscape with focus on bone metastasis

Frontiers in Immunology, 2023
Bone is among the main sites of metastasis in breast, prostate and other major cancers. Bone metastases remain incurable causing high mortality, severe skeletal-related effects and decreased quality of life.
Tiina E. Kähkönen, Jussi M. Halleen, Gary MacRitchie, Ronnie M. Andersson, Jenni Bernoulli   +4 more
doaj   +1 more source

Clinicomics-guided distant metastasis prediction in breast cancer via artificial intelligence

BMC Cancer, 2023
Background Breast cancer has become the most common malignant tumour worldwide. Distant metastasis is one of the leading causes of breast cancer-related death.
Chao Zhang, Lisha Qi, Jun Cai, Haixiao Wu, Yao Xu, Yile Lin, Zhijun Li, Vladimir P. Chekhonin, Karl Peltzer, Manqing Cao, Zhuming Yin, Xin Wang, Wenjuan Ma   +12 more
doaj   +1 more source

Transcriptomic Response to Acidosis Reveals Its Contribution to Bone Metastasis in Breast Cancer Cells

Cells, 2022
Bone is the most common site of metastasis in breast cancer. Metastasis is promoted by acidosis, which is associated with osteoporosis. To investigate how acidosis could promote bone metastasis, we compared differentially expressed genes (DEGs) in MDA-MB-
Ana Sayuri Yamagata, Paula Paccielli Freire, Nícolas Jones Villarinho, Ramon Handerson Gomes Teles, Kelliton José Mendonça Francisco, Ruy Gastaldoni Jaeger, Vanessa Morais Freitas   +6 more
doaj   +1 more source

Circulating tumor cells in breast cancer bone metastasis: mechanisms, clinical relevance, and future directions. [PDF]

Cell Death Discov
Ma L, Wang Y, Qiu S, Shi M, Tang W, Hu H, Li C, Lu H, Wang X.   +8 more
europepmc   +3 more sources

Status and future directions of anti-metastatic cancer nanomedicines for the inhibition of cathepsin L [PDF]

, 2020
Angiogenesis, tissue invasion and metastasis in the tumour microenvironment are all critical hallmarks of cancer. Upregulation of cathepsin L plays an important role in angiogenesis and metastasis through its ability to degrade the extracellular matrix ...
Pranjol, Md Zahidul I, Tabish, Tanveer A, Whatmore, Jacqueline L, Zhang, Shaowei   +3 more
core   +2 more sources

MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2. [PDF]

, 2017
MicroRNAs (miRNAs) have emerged as key players in cancer progression and metastatic initiation yet their importance in regulating prostate cancer (PCa) metastasis to bone has begun to be appreciated.
Colden, Melissa, Dahiya, Priya V, Dahiya, Rajvir, Dar, Altaf A, Majid, Shahana, Saini, Sharanjot, Shahryari, Varahram, Stein, Gary, Tanaka, Yuichiro, Yamamura, Soichiro   +9 more
core   +2 more sources

Osteocytes and Bone Metastasis [PDF]

Frontiers in Endocrinology, 2020
Bone is the most frequent site of breast cancer and prostate cancer metastasis, and one of the most common sites of metastasis for many solid tumors. Once cancer cells colonize in the bone, it imposes a major clinical challenge for the treatment of the disease, and fatality rates increase drastically.
Manuel A. Riquelme, Eduardo R. Cardenas, Jean X. Jiang   +2 more
openaire   +3 more sources

Correlation of Systemic Immune Inflammatory Index and Tumor Markers with Bone Metastasis of Lung Cancer

Zhongliu Fangzhi Yanjiu, 2022
Objective To evaluate the value of the systemic immune-inflammatory index (SII), CEA, Cyfra21-1, and NSE in predicting and diagnosing bone metastasis of lung cancer. Methods The clinical data of 618 patients with lung cancer were retrospectively analyzed.
TANG Min, LI Guixiang
doaj   +1 more source

New insight into long non-coding RNAs associated with bone metastasis of breast cancer based on an integrated analysis

Cancer Cell International, 2021
Background Bone is the most common site of metastatic breast cancer, and it is a leading cause of breast cancer-related death. This study aimed to explore bone metastasis-related long non-coding RNAs (lncRNAs) in breast cancer. Methods Four mRNA datasets
Yu Zhang, Xiaofeng Huang, Jin Liu, Guo Chen, Chengjun Liu, Sen Zhang, Jiaxin Li   +6 more
doaj   +1 more source