Results 21 to 30 of about 381,513 (352)
BMC Cancer, 2021 Background Early screening and intervention therapies are crucial to improve the prognosis of hepatocellular carcinoma (HCC) patients with bone metastasis. We aimed to identify serum lncRNA as a prediction biomarker in HCC bone metastasis.
Li Zhang +6 more
doaj +1 more source
Endo180 at the cutting edge of bone cancer treatment and beyond [PDF]
, 2016 Skeletal bone is an attractive site for secondary tumour growth and is also home to spontaneous primary cancer. Treatment of bone metastasis is focused on limiting the vicious cycle of bone destruction with bisphosphonates or inhibition of receptor ...
Sturge, Justin
core +1 more source
Macrophages and bone metastasis
Journal of Experimental Medicine, 2023 In the prostate bone metastasis microenvironment, macrophages activate a cascade that involves Activin A, the extracellular matrix, and SRC kinase and drives resistance to anti-androgen therapy. These findings (Li et al., 2023. J. Exp. Med.https://doi.org/10.1084/jem.20221007) have broad implications, including metastasis diversity in different tissue ...
Diletta Di Mitri +2 more
openaire +2 more sources
Dissecting Tumor-Stromal Interactions in Breast Cancer Bone Metastasis [PDF]
Endocrinology and Metabolism, 2016 Bone metastasis is a frequent occurrence in breast cancer, affecting more than 70% of late stage cancer patients with severe complications such as fracture, bone pain, and hypercalcemia.
Yibin Kang
doaj +1 more source
The immunohistochemical expression of leptin in lymph node metastasis from laryngeal squamous cell carcinoma (SCC) [PDF]
, 2020 Introduction: Leptin is a proteohormone produced predominantly by white adipocytes and primarily known for its key role in the control of food intake and sense of satiety.
D'Alessi S +7 more
core +1 more source
Frontiers in Oncology, 2021 AimBone metastasis is the major reason for the poor prognosis and high mortality rate of non-small cell lung cancer (NSCLC) patients. This study explored the function and underlying mechanism of Fas apoptotic inhibitory molecule 2 (FAIM2) in the bone ...
Kelin She +13 more
doaj +1 more source
Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma. [PDF]
, 2014 Ewing sarcoma is the second-most-common bone cancer in children. Driven by an oncogenic chromosomal translocation that results in the expression of an aberrant transcription factor, EWS/FLI, the disease is typically aggressive and micrometastatic upon ...
Beckerle, Mary C +8 more
core +1 more source
Pain and analgesic use associated with skeletal-related events in patients with advanced cancer and bone metastases [PDF]
, 2015 PURPOSE: Bone metastases secondary to solid tumors increase the risk of skeletal-related events (SREs), including the occurrence of pathological fracture (PF), radiation to bone (RB), surgery to bone (SB), and spinal cord compression (SCC).
A Hussain +55 more
core +2 more sources
Frontiers in Pharmacology, 2022 Prostate cancer with bone metastasis has a high cancer-specific mortality. Thus, it is essential to delineate the mechanism of bone metastasis. Pre-metastatic niche (PMN) is a concept in tumor metastasis, which is characterized by tumor-secreted factors,
Chiwei Chen +4 more
doaj +1 more source
Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces [PDF]
, 2015 The diverse composition and structure of extracellular matrix (ECM) interfaces encountered by tumor cells at secondary tissue sites can influence metastatic progression. Extensive in vitro and in vivo data has confirmed that metastasizing tumor cells can
Caley, Matthew P. +7 more
core +2 more sources