Results 21 to 30 of about 2,554,329 (307)
Insights into immuno-oncology drug development landscape with focus on bone metastasis
Frontiers in Immunology, 2023 Bone is among the main sites of metastasis in breast, prostate and other major cancers. Bone metastases remain incurable causing high mortality, severe skeletal-related effects and decreased quality of life.
Tiina E. Kähkönen +4 more
doaj +1 more source
EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation
Nature Communications, 2021 Bone metastases occur in 50–70% of patients with late-stage breast cancers and effective therapies are needed. The expression of enhancer of zeste homolog 2 (EZH2) is correlated with breast cancer metastasis, but its function in bone metastasis hasn’t ...
Lin Zhang +10 more
semanticscholar +1 more source
Clinicomics-guided distant metastasis prediction in breast cancer via artificial intelligence
BMC Cancer, 2023 Background Breast cancer has become the most common malignant tumour worldwide. Distant metastasis is one of the leading causes of breast cancer-related death.
Chao Zhang +12 more
doaj +1 more source
Nature Communications, 2021 Advanced prostate cancer (PCa) often develops bone metastasis, for which therapies are very limited and the underlying mechanisms are poorly understood.
Baotong Zhang +21 more
semanticscholar +1 more source
Bone Metastasis of Breast Cancer: Molecular Mechanisms and Therapeutic Strategies
Cancers, 2022 Simple Summary In this review, we present knowledge of the molecular mechanisms and therapeutic strategies of bone metastasis of breast cancer, particularly the interaction between metastatic breast cancer cells and the bone microenvironment in promoting
L. Pang +9 more
semanticscholar +1 more source
Cells, 2022 Bone is the most common site of metastasis in breast cancer. Metastasis is promoted by acidosis, which is associated with osteoporosis. To investigate how acidosis could promote bone metastasis, we compared differentially expressed genes (DEGs) in MDA-MB-
Ana Sayuri Yamagata +6 more
doaj +1 more source
Materials Today Bio, 2022 Organ-on-a-chip models have emerged as a powerful tool to model cancer metastasis and to decipher specific crosstalk between cancer cells and relevant regulators of this particular niche.
Francisco Conceição +8 more
semanticscholar +1 more source
Cancer Science, 2022 Bone‐related events caused by breast cancer bone metastasis substantially compromise the survival and quality of life of patients. Because triple‐negative breast cancer (TNBC) lacks hormone receptors and Her2‐targeted therapeutic options, progress in the
Ming-cang Chen +3 more
semanticscholar +1 more source
Breast Cancer Bone Metastasis: A Narrative Review of Emerging Targeted Drug Delivery Systems
Cells, 2022 Bone is one of the most common metastatic sites among breast cancer (BC) patients. Once bone metastasis is developed, patients’ survival and quality of life will be significantly declined. At present, there are limited therapeutic options for BC patients
Huimin Shao, P. Varamini
semanticscholar +1 more source
Molecular Cancer, 2021 Breast cancer (BC) has a marked tendency to spread to the bone, resulting in significant skeletal complications and mortality. Recently, circular RNAs (circRNAs) have been reported to contribute to cancer initiation and progression. However, the function
Yingru Xu +14 more
semanticscholar +1 more source