Results 31 to 40 of about 379,930 (351)
NKX2-8/PTHrP Axis-Mediated Osteoclastogenesis and Bone Metastasis in Breast Cancer
Frontiers in Oncology, 2022 Bone metastasis is one of the most common distant metastasis of breast cancer, which could cause serious skeletal disease and increased cancer-related death.
Ainiwaerjiang Abudourousuli +15 more
doaj +1 more source
Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces [PDF]
, 2015 The diverse composition and structure of extracellular matrix (ECM) interfaces encountered by tumor cells at secondary tissue sites can influence metastatic progression. Extensive in vitro and in vivo data has confirmed that metastasizing tumor cells can
Caley, Matthew P. +7 more
core +2 more sources
Frontiers in Pharmacology, 2022 Prostate cancer with bone metastasis has a high cancer-specific mortality. Thus, it is essential to delineate the mechanism of bone metastasis. Pre-metastatic niche (PMN) is a concept in tumor metastasis, which is characterized by tumor-secreted factors,
Chiwei Chen +4 more
doaj +1 more source
TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling [PDF]
, 2013 In patients, non-proliferative disseminated tumour cells (DTCs) can persist in the bone marrow (BM) while other organs (such as lung) present growing metastasis.
Aguirre Ghiso, Julio A. +7 more
core +2 more sources
Chinese Journal of Lung Cancer, 2013 Background and objective Bone metastasis is common in lung cancer patients. The β isomer of the C-terminal telopeptide of type I collagen (β-CTX) and bone-specific alkaline phosphates (BAP) are regarded as important bone turnover markers in bone ...
Qiong TANG +3 more
doaj +1 more source
Trends in Bone Metastasis Modeling [PDF]
Cancers, 2020 Bone is one of the most common sites for cancer metastasis. Bone tissue is composed by different kinds of cells that coexist in a coordinated balance. Due to the complexity of bone, it is impossible to capture the intricate interactions between cells under either physiological or pathological conditions.
Laranga R. +5 more
openaire +4 more sources
Zhongliu Fangzhi Yanjiu, 2019 Objective To investigate the relationship between tumor markers of lung cancer and bone metastasis of whole body bone imaging in lung adenocarcinoma. Methods The whole body bone imaging of 278 patients diagnosed as lung adenocarcinoma in our hospital was
CAO Zhongnian +5 more
doaj +1 more source
Frontiers in Oncology, 2022 BackgroundWhile bone metastasis is not common in gastric adenocarcinoma (GaC), it can have important impacts on prognosis. This large cohort study aimed at exploring factors associated with bone metastasis in GaC and investigating the time-dependent ...
Lei Huang +7 more
doaj +1 more source
Hallmarks of Bone Metastasis [PDF]
Calcified Tissue International, 2017 Breast cancer bone metastasis develops as the result of a series of complex interactions between tumor cells, bone marrow cells, and resident bone cells. The net effect of these interactions are the disruption of normal bone homeostasis, often with significantly increased osteoclast and osteoblast activity, which has provided a rational target for ...
Rachelle W. Johnson, Larry J. Suva
openaire +2 more sources
Sclerostin inhibition alleviates breast cancer-induced bone metastases and muscle weakness [PDF]
, 2019 Breast cancer bone metastases often cause a debilitating non-curable condition with osteolytic lesions, muscle weakness and a high mortality. Current treatment comprises chemotherapy, irradiation, surgery and anti-resorptive drugs that restrict but do ...
Brandt, Diana +5 more
core +1 more source