Results 31 to 40 of about 2,554,329 (307)

The Signaling Pathways Associated With Breast Cancer Bone Metastasis

Frontiers in Oncology, 2022
Background Breast cancer (BC) is now the leading cause of cancer in women, and bone is the primary site of distant BC metastasis. BC bone metastasis seriously affects the quality of life of patients and increases the mortality rate.
Xuelian Song, Changran Wei, Xiangqi Li
semanticscholar   +1 more source

UBE2S as a novel ubiquitinated regulator of p16 and β-catenin to promote bone metastasis of prostate cancer

International Journal on Biological Sciences, 2022
Bone metastasis is the main site of metastasis and causes the most deaths in patients with prostate cancer (PCa). The mechanism of bone metastasis is complex and not fully clarified. By RNA sequencing and analysing key pathways in bone metastases of PCa,
Shengmeng Peng, Xu Chen, Chao-yun Huang, Chenwei Yang, Minyi Situ, Qianghua Zhou, Y. Ling, Hao Huang, Ming Huang, Yangjie Zhang, Liang Cheng, Qiang Zhang, Zheng-hui Guo, Yiming Lai, Jian Huang   +14 more
semanticscholar   +1 more source

Integrin alpha5 in human breast cancer is a mediator of bone metastasis and a therapeutic target for the treatment of osteolytic lesions

Oncogene, 2021
Bone metastasis remains a major cause of mortality and morbidity in breast cancer. Therefore, there is an urgent need to better select high-risk patients in order to adapt patient’s treatment and prevent bone recurrence.
F. Pantano, M. Croset, K. Driouch, N. Bednarz-Knoll, M. Iuliani, G. Ribelli, E. Bonnelye, H. Wikman, S. Geraci, F. Bonin, S. Simonetti, B. Vincenzi, Saw-See Hong, S. Sousa, K. Pantel, G. Tonini, D. Santini, P. Clézardin   +17 more
semanticscholar   +1 more source

Breast Cancer with Bone Metastasis: Molecular Insights and Clinical Management

Cells, 2021
Despite the remarkable advances in the diagnosis and treatment of breast cancer patients, the presence or development of metastasis remains an incurable condition.
K. Venetis, Roberto Piciotti, E. Sajjadi, M. Invernizzi, S. Morganti, C. Criscitiello, N. Fusco   +6 more
semanticscholar   +1 more source

Osteocytes and Bone Metastasis [PDF]

Frontiers in Endocrinology, 2020
Bone is the most frequent site of breast cancer and prostate cancer metastasis, and one of the most common sites of metastasis for many solid tumors. Once cancer cells colonize in the bone, it imposes a major clinical challenge for the treatment of the disease, and fatality rates increase drastically.
Manuel A. Riquelme, Eduardo R. Cardenas, Jean X. Jiang   +2 more
openaire   +3 more sources

New insight into long non-coding RNAs associated with bone metastasis of breast cancer based on an integrated analysis

Cancer Cell International, 2021
Background Bone is the most common site of metastatic breast cancer, and it is a leading cause of breast cancer-related death. This study aimed to explore bone metastasis-related long non-coding RNAs (lncRNAs) in breast cancer. Methods Four mRNA datasets
Yu Zhang, Xiaofeng Huang, Jin Liu, Guo Chen, Chengjun Liu, Sen Zhang, Jiaxin Li   +6 more
doaj   +1 more source

Correlation of Systemic Immune Inflammatory Index and Tumor Markers with Bone Metastasis of Lung Cancer

Zhongliu Fangzhi Yanjiu, 2022
Objective To evaluate the value of the systemic immune-inflammatory index (SII), CEA, Cyfra21-1, and NSE in predicting and diagnosing bone metastasis of lung cancer. Methods The clinical data of 618 patients with lung cancer were retrospectively analyzed.
TANG Min, LI Guixiang
doaj   +1 more source

Current progress and mechanisms of bone metastasis in lung cancer: a narrative review

Translational Lung Cancer Research, 2021
Lung cancer is a kind of malignant tumor with rapid progression and poor prognosis. Distant metastasis has been the main cause of mortality among lung cancer patients. Bone is one of the most common sites.
Shengyu Wu, Yue Pan, Yanyu Mao, Yu Chen, Yayi He   +4 more
semanticscholar   +1 more source

Serum lnc34a is a potential prediction biomarker for bone metastasis in hepatocellular carcinoma patients

BMC Cancer, 2021
Background Early screening and intervention therapies are crucial to improve the prognosis of hepatocellular carcinoma (HCC) patients with bone metastasis. We aimed to identify serum lncRNA as a prediction biomarker in HCC bone metastasis.
Li Zhang, Hao Niu, Ping Yang, Jie Ma, Bao-Ying Yuan, Zhao-Chong Zeng, Zuo-Lin Xiang   +6 more
doaj   +1 more source

Macrophages and bone metastasis

Journal of Experimental Medicine, 2023
In the prostate bone metastasis microenvironment, macrophages activate a cascade that involves Activin A, the extracellular matrix, and SRC kinase and drives resistance to anti-androgen therapy. These findings (Li et al., 2023. J. Exp. Med.https://doi.org/10.1084/jem.20221007) have broad implications, including metastasis diversity in different tissue ...
Diletta Di Mitri, Fabio Conforti, Alberto Mantovani   +2 more
openaire   +2 more sources