Results 11 to 20 of about 137,665 (299)

An osteoinductive and biodegradable intramedullary implant accelerates bone healing and mitigates complications of bone transport in male rats

Nature Communications, 2023
Bone transport is a surgery-driven procedure for the treatment of large bone defects. However, challenging complications include prolonged consolidation, docking site nonunion and pin tract infection.
Sien Lin, Hirotsugu Maekawa, Seyedsina Moeinzadeh, Elaine Lui, Hossein Vahid Alizadeh, Jiannan Li, Sungwoo Kim, Michael Poland, Benjamin C. Gadomski, Jeremiah T. Easley, Jeffrey Young, Michael Gardner, David Mohler, William J. Maloney, Yunzhi Peter Yang   +14 more
doaj   +1 more source

Bone morphogenetic protein-2 influence on metabolic activity and proteoglycan synthesis by intervertebral disc cells

Acta Biomedica Scientifica, 2016
Modern therapeutic strategies for intervertebral disc repair mainly focus on targeting molecular pathways of extracellular matrix degeneration. Anabolic strategies for regeneration are aimed to increase production of major extracellular molecules ...
L. A. Bardonova, E. G. Belykh, V. A. Byvaltsev   +2 more
doaj   +1 more source

Is NO the Answer? The Nitric Oxide Pathway Can Support Bone Morphogenetic Protein 2 Mediated Signaling [PDF]

, 2019
The growth factor bone morphogenetic protein 2 (BMP2) plays an important role in bone development and repair. Despite the positive effects of BMP2 in fracture healing, its use is associated with negative side effects and poor cost effectiveness, partly ...
Bormann, Nicole, Differ, Christopher, Klatte-Schulz, Franka, Knaus, Petra, Minkwitz, Susann, Wildemann, Britt   +5 more
core   +1 more source

Effects of bioactive glass S53P4 or beta-tricalcium phosphate and bone morphogenetic protein-2 and bone morphogenetic protein-7 on osteogenic differentiation of human adipose stem cells

Journal of Tissue Engineering, 2012
The effects of bioactive glass S53P4 or beta-tricalcium phosphate; and bone morphogenetic proteins bone morphogenetic protein-2, bone morphogenetic protein-7, or bone morphogenetic protein-2 + 7 on osteogenic differentiation of human adipose stem cells ...
Martin Waselau, Mimmi Patrikoski, Miia Juntunen, Kasperi Kujala, Minna Kääriäinen, Hannu Kuokkanen, George K Sándor, Outi Vapaavuori, Riitta Suuronen, Bettina Mannerström, Brigitte von Rechenberg, Susanna Miettinen   +11 more
doaj   +1 more source

Preliminary evaluation of BMP-2-derived peptide in repairing a peri-implant critical size defect: A canine model

Journal of the Formosan Medical Association, 2021
Background/Purpose: A synthetic bone morphogenetic protein (BMP)-2-derived peptide has been discovered to promote bone regeneration. The present study investigated the potential of the BMP-2 peptide combined with hydroxyapatite (HAp)/β-tricalcium ...
Yueh-Ling Chao, Li-Deh Lin, Hao-Hueng Chang, Tong-Mei Wang   +3 more
doaj   +1 more source

Addition of bone morphogenetic protein type 2 to ascorbate and β-glycerophosphate supplementation did not enhance osteogenic differentiation of human adipose-derived stem cells

Journal of Applied Oral Science, 2012
Bone morphogenetic protein type 2 (BMP-2) is a potent local factor, which promotes bone formation and has been used as an osteogenic supplement for mesenchymal stem cells.
Ariadne Cristiane Cabral Cruz, Mariana Lúcia Silva, Thiago Caon, Cláudia Maria Oliveira Simões   +3 more
doaj   +1 more source

Multiple roles of ALK3 in osteoarthritis: a narrative review

Bone & Joint Research, 2023
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by progressive cartilage degradation, synovial membrane inflammation, osteophyte formation, and subchondral bone sclerosis.
Xianchun Ruan, Jinning Gu, Mingyang Chen, Fulin Zhao, Munire Aili, Demao Zhang   +5 more
doaj   +1 more source

Effect of sonic hedgehog/β-TCP composites on bone healing within the critical-sized rat femoral defect [PDF]

, 2013
The creation of entirely synthetically derived bone substitute materials which are as effective as autologous bone grafts is desirable. Osteogenesis involves the concerted action of several proteins within a signaling cascade.
Flinspach, Armin Niklas, Henrich, Dirk, Marzi, Ingo, Seebach, Caroline, Warzecha, Jörg, Wenger, Florian   +5 more
core   +1 more source

Cellular Response to Bone Morphogenetic Proteins-2 and -7 Covalently Bound to Photocrosslinked Heparin–Diazoresin Multilayer

Biomolecules, 2023
Despite the plethora of research that exists on recombinant human bone morphogenetic protein-2 and -7 (rhBMP-2 and rhBMP-7) and has been clinically approved, there is still a need to gain information that would allow for their more rational use in bone ...
Magdalena Wytrwal, Małgorzata Sekuła-Stryjewska, Agata Pomorska, Ewa Oclon, Ewa Zuba-Surma, Szczepan Zapotoczny, Krzysztof Szczubiałka   +6 more
doaj   +1 more source

Adsorption and release of BMP-2 on nanocrystalline apatite-coated and uncoated hydroxyapatite/b-tricalcium phosphate porous ceramics [PDF]

, 2009
The association of bone morphogenetic proteins (BMPs) with calcium phosphate bioceramics is known to confer them osteoinductive properties. The aim of this study was to evaluate the surface properties, especially regarding recombinant human BMP-2 (rhBMP-
Alam, Baig, Barroug, Barroug, Benaziz, Bohic, Boix, Charlot, Coradin, Daculsi, Dong, Frolik, Habibovic, Habibovic, Hayakawa, Hughes Wassell, Klenke, Le Nihouannen, Liu, Liu, Matsumoto, Midy, Midy, Murata, Ouizat, Rey, Rey, Rey, Rouahi, Ruppert, Scheufler, Schmoekel, Seeherman, Sumner, Tsujigiwa, Uludag, Vehof, Yuan, Zisch   +38 more
core   +3 more sources