Bone Morphogenetic Protein-2 in Development and Bone Homeostasis [PDF]
Journal of Developmental Biology, 2020 Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many developmental processes, including cardiogenesis, neurogenesis, and ...
Daniel Halloran +2 more
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Ectopic Laryngeal Ossification after Bone Morphogenetic Protein-2 [PDF]
Surgeries, 2021 We report two cases of ectopic bone formation in the head and neck following treatment with recombinant human bone morphogenetic protein-2 (rhBMP-2). Surgical pathologic data, laryngoscopy imaging, CT imaging, and patient medical history were obtained ...
Kirsten Wong +2 more
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Bone morphogenetic protein 2: heterologous expression and potential in bone regeneration
Actualidades Biológicas, 2021 Currently, bone morphogenetic protein 2 (BMP-2) is one of the two osteoinductive growth factors used in medical devices to promote bone formation. Typically, this protein is bought from commercial houses at high rates and in small quantities that are not
Andrea Mesa-Restrepo +2 more
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Bone morphogenetic protein-2-derived osteogenic peptide promotes bone regeneration via osteoblastogenesis [PDF]
Regenerative TherapyIntroduction: Bone morphogenetic protein (BMP)-2 plays a critical role in stimulating human mesenchymal stromal cells (hMSCs) differentiation, a key process in bone regeneration.
Jong-Bin Lee +6 more
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Focused Ultrasound-Mediated Release of Bone Morphogenetic Protein 2 from Hydrogels for Bone Regeneration [PDF]
GelsAn ultrasound-responsive hydrogel system was developed that provides on-demand release when stimulated by focused ultrasound (fUS). Diels–Alder cycloadducts crosslinked polyethylene glycol (PEG) hydrogels and underwent a retrograde Diels–Alder reaction ...
Tyus J. Yeingst +6 more
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Potentiating effect of AMD3100 on bone morphogenetic protein-2 induced bone regeneration [PDF]
Maxillofacial Plastic and Reconstructive SurgeryBackground AMD3100, a CXCR4 antagonist, is currently prescribed for activating the mobilization of hematopoietic stem cells. Recently, AMD3100 was shown to potentiate bone morphogenetic protein-2 (BMP-2)-induced bone formation by stimulating the ...
Gyu-Jo Shim +4 more
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Cell-permeable bone morphogenetic protein 2 facilitates bone regeneration by promoting osteogenesis [PDF]
Materials Today BioThe use of the FDA-approved osteoinductive growth factor BMP2 is widespread for bone regeneration. However, its clinical application has been hindered by limitations in cell permeability and a short half-life in circulation.
Mingu Kang +7 more
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Journal of the Formosan Medical Association, 2021 Background/Purpose: A synthetic bone morphogenetic protein (BMP)-2-derived peptide has been discovered to promote bone regeneration. The present study investigated the potential of the BMP-2 peptide combined with hydroxyapatite (HAp)/β-tricalcium ...
Yueh-Ling Chao +3 more
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Biomolecules, 2023 Despite the plethora of research that exists on recombinant human bone morphogenetic protein-2 and -7 (rhBMP-2 and rhBMP-7) and has been clinically approved, there is still a need to gain information that would allow for their more rational use in bone ...
Magdalena Wytrwal +6 more
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Heterodimeric BMP-2/7 antagonizes the inhibition of all-trans retinoic acid and promotes the osteoblastogenesis. [PDF]
PLoS ONE, 2013 OBJECTIVES: Hypervitaminosis A and alcoholism can result in a low mineral density and compromised regenerative capacity of bone, thus delaying implant osteointegration.
Wenjuan Bi +5 more
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