Results 1 to 10 of about 79,226 (304)

Comparative analysis of bone regeneration in critical-sized defects using self-assembling peptide hydrogel-178, bone morphogenetic protein-2, and calcium phosphate scaffolds in a rat femur model. [PDF]

Nagoya J Med Sci
Yamauchi I, Nakashima H, Ito S, Segi N, Ouchida J, Morita Y, Ode Y, Nagatani Y, Okada Y, Ando K, Imagama S.   +10 more
europepmc   +3 more sources

Preliminary evaluation of BMP-2-derived peptide in repairing a peri-implant critical size defect: A canine model

Journal of the Formosan Medical Association, 2021
Background/Purpose: A synthetic bone morphogenetic protein (BMP)-2-derived peptide has been discovered to promote bone regeneration. The present study investigated the potential of the BMP-2 peptide combined with hydroxyapatite (HAp)/β-tricalcium ...
Yueh-Ling Chao, Li-Deh Lin, Hao-Hueng Chang, Tong-Mei Wang   +3 more
doaj   +1 more source

Bone morphogenetic protein-2 delivery by bone substitute materials

, 2011
Patrick Hänseler
openalex   +2 more sources

Bone Morphogenetic Protein-2 Stimulates Runx2 Acetylation [PDF]

Journal of Biological Chemistry, 2006
Runx2/Cbfa1/Pebp2aA is a global regulator of osteogenesis and is crucial for regulating the expression of bone-specific genes. Runx2 is a major target of the bone morphogenetic protein (BMP) pathway. Genetic analysis has revealed that Runx2 is degraded through a Smurf-mediated ubiquitination pathway, and its activity is inhibited by HDAC4.
Eun-Joo, Jeon, Kwang-Youl, Lee, Nam-Sook, Choi, Mi-Hye, Lee, Hyun-Nam, Kim, Yun-Hye, Jin, Hyun-Mo, Ryoo, Je-Yong, Choi, Minoru, Yoshida, Norikazu, Nishino, Byung-Chul, Oh, Kyeong-Sook, Lee, Yong Hee, Lee, Suk-Chul, Bae   +13 more
openaire   +2 more sources

Cellular Response to Bone Morphogenetic Proteins-2 and -7 Covalently Bound to Photocrosslinked Heparin–Diazoresin Multilayer

Biomolecules, 2023
Despite the plethora of research that exists on recombinant human bone morphogenetic protein-2 and -7 (rhBMP-2 and rhBMP-7) and has been clinically approved, there is still a need to gain information that would allow for their more rational use in bone ...
Magdalena Wytrwal, Małgorzata Sekuła-Stryjewska, Agata Pomorska, Ewa Oclon, Ewa Zuba-Surma, Szczepan Zapotoczny, Krzysztof Szczubiałka   +6 more
doaj   +1 more source

Heterodimeric BMP-2/7 antagonizes the inhibition of all-trans retinoic acid and promotes the osteoblastogenesis. [PDF]

PLoS ONE, 2013
OBJECTIVES: Hypervitaminosis A and alcoholism can result in a low mineral density and compromised regenerative capacity of bone, thus delaying implant osteointegration.
Wenjuan Bi, Zhiyuan Gu, Yuanna Zheng, Xiao Zhang, Jing Guo, Gang Wu   +5 more
doaj   +1 more source

Bone Morphogenetic Protein-2 Induces Proinflammatory Endothelial Phenotype [PDF]

The American Journal of Pathology, 2006
The transforming growth factor-beta superfamily member bone morphogenetic protein-2 (BMP-2) is up-regulated in atherosclerotic arteries; however, its effects on the endothelium are not well characterized. Using microdissected coronary arterial endothelial cells (CAECs) and cultured primary CAECs, we demonstrated endothelial mRNA expression of BMP-2 and
Anna, Csiszar, Mansoor, Ahmad, Kira E, Smith, Nazar, Labinskyy, Qun, Gao, Gabor, Kaley, John G, Edwards, Michael S, Wolin, Zoltan, Ungvari   +8 more
openaire   +2 more sources

Bone morphogenetic protein-2 influence on metabolic activity and proteoglycan synthesis by intervertebral disc cells

Acta Biomedica Scientifica, 2016
Modern therapeutic strategies for intervertebral disc repair mainly focus on targeting molecular pathways of extracellular matrix degeneration. Anabolic strategies for regeneration are aimed to increase production of major extracellular molecules ...
L. A. Bardonova, E. G. Belykh, V. A. Byvaltsev   +2 more
doaj   +1 more source

Bone Morphogenetic Protein as Bone Additive around Dental Implant and its Impact on Osseointegration: a Systematic Review [PDF]

Journal of Dentistry, 2022
Statement of the Problem: Bone morphogenetic protein (BMP), a potential osteoinductive agent, was systematically reviewed for merits and demerits when used as a bone additive that was intervened during the surgical phase of dental implant placement; and ...
Fathima Banu Raza , Sivakumar Vijayaragavalu , Anand Kumar Vaidyanathan   +2 more
doaj   +1 more source

Bone morphogenetic protein-2 and bone therapy: successes and pitfalls [PDF]

Journal of Pharmacy and Pharmacology, 2016
Abstract Objectives Bone morphogenetic proteins (BMPs), more specifically BMP-2, are being increasingly used in orthopaedic surgery due to advanced research into osteoinductive factors that may enhance and improve bone therapy.
Poon, B., Kha, T., Tran, S., Dass, Crispin   +3 more
openaire   +3 more sources