Results 191 to 200 of about 88,042,096 (284)

High glucose promotes mineralization via bone morphogenetic protein 4-Smad signals in early stage of osteoblast differentiation. [PDF]

Diabetol Int, 2021
Takeno A, Kanazawa I, Tanaka KI, Notsu M, Kanasaki K, Oono T, Ogawa Y, Sugimoto T.   +7 more
europepmc   +1 more source

A luminal non‐coding RNA‐based genomic classifier confirms favourable outcomes in patients with clinically organ‐confined bladder cancer treated with radical cystectomy

BJU International, Volume 135, Issue 4, Page 648-656, April 2025.
Objective To further evaluate a genomic classifier (GC) in a cohort of patients undergoing radical cystectomy (RC), as long non‐coding RNA (lncRNA)‐based genomic profiling has suggested utility in identifying a distinct tumour subgroup corresponding to a favourable prognosis in patients with bladder cancer.
Joep J. de Jong, James A. Proudfoot, Siamak Daneshmand, Robert S. Svatek, Vikram Narayan, Ewan A. Gibb, Elai Davicioni, Shreyas Joshi, Aaron Dahmen, Roger Li, Brant A. Inman, Paras Shah, Iftach Chaplin, Jonathan Wright, Yair Lotan   +14 more
wiley   +1 more source

The fight of innate immunity and abnormal cannabinoids against Candida infection

British Journal of Pharmacology, EarlyView.
Candida species represent the most clinically significant fungal pathogens in humans, with invasive candidiasis carrying a mortality of 30%–40% in critically ill patients despite modern antifungal therapy. The innate immune system – through the coordinated and specific activities of neutrophils, macrophages, NK cells, mast cells and eosinophils ...
Prince Ofori, Ilan Zaffran, Francesca Levi Schaffer   +2 more
wiley   +1 more source

YTHDF3 Enhances Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoporosis by Promoting TBX19 Expression

Cell Proliferation, EarlyView.
In this study, OP‐BMSCs were successfully isolated from OVX osteoporotic rats. Mechanistic investigations revealed that the RNA‐binding protein YTHDF3 significantly upregulates Tbx19 expression by enhancing the stability of Tbx19 mRNA. Elevated Tbx19 levels, in turn, activate key osteogenic molecules, effectively promoting the differentiation of OP ...
Qianke Tao, Qiaonan Ye, Chengpeng Yang, Yuping Xie, Xuemei Long, Long Bai, Zhiyuan Zhang, Qianwei Li, Dan Tan, Jingang Xiao   +9 more
wiley   +1 more source

Recombinant bone morphogenetic protein (BMP)-2 regulates costochondral growth plate chondrocytes and induces expression of BMP-2 and BMP-4 in a cell maturation-dependent manner

, 1997
Summary: This study examined the effect of recombinant human bone morphogenetic protein-2 on several parameters of growth, differentiation, and matrix synthesis and on the endogenous production of mRNA of bone morphogenetic proteins 2 and 4 by growth ...
¶z Schwartz, $ D §b, TD S E D Harris, M A Harris, D M Erickson, #j M Wozney, B D Boyan, Dean, Boyan   +8 more
core  

Tetrahedral Framework Nucleic Acid Delivery of miR‐210‐3p Promotes Femoral Bone Regeneration Through EFNA3/AKT/STAT3‐Mediated Immunomodulation

Cell Proliferation, EarlyView.
Schematic of tFNA‐miR‐210‐3p fabrication, macrophage regulation and femoral defect therapy: it enters macrophages, inhibits EFNA3 to induce M2 polarisation and boosts rat bone repair in vivo. ABSTRACT Persistent inflammation, insufficient vascularization and impaired osteogenesis limit the repair of critical‐sized femoral defects. Although microRNA‐210‐
Lei Hu, Kaixiao Xue, Jiahu Fang, Weitong Cui   +3 more
wiley   +1 more source

Platelet concentrates in sinus augmentation: The impact of platelet dose and biological characteristics—A systematic review and meta‐analysis

European Journal of Oral Sciences, EarlyView.
Abstract This systematic review investigated the osteogenic effects of platelet concentrate (PRF/PRP) when combined with non‐autogenous graft materials in sinus lift procedures. Key characteristics assessed included platelet concentration, total platelet dose, leukocyte content, and fibrin‐network structure.
Olav Kansgar Straum, Hans Thomas Brox, Juliane Hesse, Andreas Jörn Schmalfuss, Erlend Bugge   +4 more
wiley   +1 more source

Bone morphogenetic protein 4 (BMP4) promotes hepatic glycogen accumulation and reduces glucose level in hepatocytes through mTORC2 signaling pathway. [PDF]

Genes Dis, 2021
An L, Shi Q, Zhu Y, Wang H, Peng Q, Wu J, Cheng Y, Zhang W, Yi Y, Bao Z, Zhang H, Luo Y, Fan J.   +12 more
europepmc   +1 more source

Treatment approaches for equine subchondral lucencies: Clinical considerations and therapeutic decision‐making

Equine Veterinary Education, EarlyView.
Summary Subchondral lucencies, also referred to as subchondral cystic lesions or osseous cyst‐like lesions, are radiographically identifiable defects of subchondral bone that remain an important cause of lameness and reduced athletic performance in horses.
C. Salazar‐Latorre, R. Salcedo‐Jiménez, M. Masri‐Daba   +2 more
wiley   +1 more source

Mechanisms underpinning the progression of nondysplastic Barrett's oesophagus to cancer

The FEBS Journal, EarlyView.
Barrett's oesophagus confers a low but significant cancer risk. The condition is common but we do not have effective biomarkers to identify susceptible patients. We believe that there is no single factor that determines cancer risk and an understanding of the combinations of interactions (via gene expression and natural selection) between the Barrett's
Yannick H. Derwa, Meng‐Lay Lin, Stuart A. C. McDonald   +2 more
wiley   +1 more source