Development of a Metaphyseal Non-Union Model in the Osteoporotic Rat Femur
Bioengineering, 2023 The aim of this current study was to establish a metaphyseal femoral non-union model in osteoporotic rats by comparing a power tool versus a manual tool for fracture creation. Twelve adult female Sprague Dawley rats were ovariectomized (OVX) and received
Amelie Deluca +8 more
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Silicon substituted hydroxyapatite/VEGF scaffolds stimulate bone regeneration in osteoporotic sheep [PDF]
Acta Biomaterialia 101, 544-553 (2019), 2021 Silicon-substituted hydroxyapatite (SiHA) macroporous scaffolds have been prepared by robocasting. In order to optimize their bone regeneration properties, we have manufactured these scaffolds presenting different microstructures: nanocrystalline and crystalline. Moreover, their surfaces have been decorated with vascular endothelial growth factor (VEGF)
arxiv +1 more source
Ex Vivo Osteogenesis Induced by Calcium Silicate-Based Cement Extracts
Journal of Functional Biomaterials, 2023 Calcium silicate-based cements are used in a variety of clinical conditions affecting the pulp tissue, relying on their inductive effect on tissue mineralization.
Gabriel Kato +5 more
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Immunoporosis: Role of immune system in the pathophysiology of different types of osteoporosis
Frontiers in Endocrinology, 2022 Osteoporosis is a skeletal system disease characterized by low bone mass and altered bone microarchitecture, with an increased risk of fractures. Classical theories hold that osteoporosis is essentially a bone remodeling disorder caused by estrogen ...
Weidong Zhang +13 more
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Journal of Functional Biomaterials, 2022 Bone tissue infection is a major clinical challenge with high morbidity and a significant healthcare burden. Therapeutic approaches are usually based on systemic antibacterial therapies, despite the potential adverse effects associated with antibiotic ...
Lorena Castro Mariano +2 more
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Mesoporous bioactive glass/e-polycaprolactone scaffolds promote bone regeneration in osteoporotic sheep [PDF]
Acta Biomaterialia 90 (2019) 3693-402, 2021 Macroporous scaffolds made of a SiO2-CaO-P2O5 mesoporous bioactive glass (MBG) and epolycaprolactone (PCL) have been prepared by robocasting. These scaffolds showed an excellent in vitro biocompatibility in contact with osteoblast like cells (Saos 2) and osteoclasts derived from RAW 264.7 macrophages.
arxiv +1 more source
Osteostatin potentiates the bioactivity of mesoporous glass scaffolds containing Zn2+ ions in human mesenchymal stem cell cultures [PDF]
Acta Biomaterialia. 89 (2019) 359-371, 2021 There is an urgent need of biosynthetic bone grafts with enhanced osteogenic capacity. In this study, we describe the design of hierarchical meso-macroporous 3D-scaffolds based on mesoporous bioactive glasses (MBGs), enriched with the peptide osteostatin and Zn2+ ions, and their osteogenic effect on human mesenchymal stem cells (hMSCs) as a preclinical
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Cerium (III) and (IV) containing mesoporous glasses/alginate beads for bone regeneration: bioactivity, biocompatibility and reactive oxygen species activity [PDF]
Materials for Biological Applications. 105, 109971. 2019, 2021 A very small number of biomaterials investigated for bone regeneration was reported as able to prevent the oxidative stress. In this study beads based on alginate hydrogel and mesoporous glasses (MG) containing different amounts of cerium oxides (Ce3+/Ce4+) exhibiting antioxidant properties were investigated as a good approach to mimic the action of ...
arxiv +1 more source
Induction of VEGF secretion from bone marrow stromal cell line (ST-2) by the dissolution products of mesoporous silica glass particles containing CuO and SrO [PDF]
J. Non-cryst. Solids. 500, 217-224 (2018), 2021 Certain biomaterials are capable of inducing the secretion of Vascular Endothelial Growth Factor (VEGF) from cells exposed to their biochemical influence, which plays a vital role in stimulating angiogenesis. Looking for this capacity, in this study three porous glasses were synthesized and characterized.
arxiv +1 more source
Frontiers in Bioengineering and Biotechnology, 2023 Background: Diabetes-associated periodontitis (DPD) is an inflammatory and destructive disease of periodontal tissues in the diabetic population. The disease is manifested as more severe periodontal destruction and is more difficult to treat when ...
Ruihan Gao +11 more
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