Results 1 to 10 of about 196,593 (268)

Development of a Metaphyseal Non-Union Model in the Osteoporotic Rat Femur

Bioengineering, 2023
The aim of this current study was to establish a metaphyseal femoral non-union model in osteoporotic rats by comparing a power tool versus a manual tool for fracture creation. Twelve adult female Sprague Dawley rats were ovariectomized (OVX) and received
Amelie Deluca, Andrea Wagner, Bettina Faustini, Nadja Weissenbacher, Christian Deininger, Florian Wichlas, Herbert Tempfer, Ernst J. Mueller, Andreas Traweger   +8 more
doaj   +1 more source

Ex Vivo Osteogenesis Induced by Calcium Silicate-Based Cement Extracts

Journal of Functional Biomaterials, 2023
Calcium silicate-based cements are used in a variety of clinical conditions affecting the pulp tissue, relying on their inductive effect on tissue mineralization.
Gabriel Kato, Rita Araújo, Cláudia Rodrigues, Pedro Sousa Gomes, Liliana Grenho, Maria Helena Fernandes   +5 more
doaj   +1 more source

Immunoporosis: Role of immune system in the pathophysiology of different types of osteoporosis

Frontiers in Endocrinology, 2022
Osteoporosis is a skeletal system disease characterized by low bone mass and altered bone microarchitecture, with an increased risk of fractures. Classical theories hold that osteoporosis is essentially a bone remodeling disorder caused by estrogen ...
Weidong Zhang, Weidong Zhang, Ruihan Gao, Ruihan Gao, Xing Rong, Xing Rong, Siqi Zhu, Siqi Zhu, Yajun Cui, Yajun Cui, Hongrui Liu, Hongrui Liu, Minqi Li, Minqi Li   +13 more
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Antimicrobial Biomaterials for the Healing of Infected Bone Tissue: A Systematic Review of Microtomographic Data on Experimental Animal Models

Journal of Functional Biomaterials, 2022
Bone tissue infection is a major clinical challenge with high morbidity and a significant healthcare burden. Therapeutic approaches are usually based on systemic antibacterial therapies, despite the potential adverse effects associated with antibiotic ...
Lorena Castro Mariano, Maria Helena Raposo Fernandes, Pedro Sousa Gomes   +2 more
doaj   +1 more source

Eldecalcitol effectively prevents alveolar bone loss by partially improving Th17/Treg cell balance in diabetes-associated periodontitis

Frontiers in Bioengineering and Biotechnology, 2023
Background: Diabetes-associated periodontitis (DPD) is an inflammatory and destructive disease of periodontal tissues in the diabetic population. The disease is manifested as more severe periodontal destruction and is more difficult to treat when ...
Ruihan Gao, Ruihan Gao, Weidong Zhang, Weidong Zhang, Yujun Jiang, Yujun Jiang, Junzhe Zhai, Jian Yu, Hongrui Liu, Hongrui Liu, Minqi Li, Minqi Li   +11 more
doaj   +1 more source

Exendin-4 and eldecalcitol synergistically promote osteogenic differentiation of bone marrow mesenchymal stem cells through M2 macrophages polarization via PI3K/AKT pathway

Stem Cell Research & Therapy, 2022
Background The incidence of diabetic osteoporosis is increasing. This article evaluates the effect of combination treatment with the hypoglycemic drug exendin-4 (Ex-4) and the vitamin D analog eldecalcitol (ED-71) on improving diabetic osteoporosis and ...
Yupu Lu, Shanshan Liu, Panpan Yang, Yuying Kou, Congshan Li, Hongrui Liu, Minqi Li   +6 more
doaj   +1 more source

Simulating In Vitro the Bone Healing Potential of a Degradable and Tailored Multifunctional Mg-Based Alloy Platform

Bioengineering, 2022
This work intended to elucidate, in an in vitro approach, the cellular and molecular mechanisms occurring during the bone healing process, upon implantation of a tailored degradable multifunctional Mg-based alloy.
Victor Martin, Mónica Garcia, Maria de Fátima Montemor, João Carlos Salvador Fernandes, Pedro Sousa Gomes, Maria Helena Fernandes   +5 more
doaj   +1 more source

Impact of activating Notch signaling in osteocytes on osteogenic differentiation of bone marrow stromal cells in vitro

Di-san junyi daxue xuebao, 2020
Objective To investigate the effect and underlying mechanism of activating Notch signaling in osteocytes on osteogenic differentiation of bone marrow stromal cells (BMSCs). Methods The osteocytes derived from RosaNotch mice were infected with recombinant
XIE Yingchun, TU Xiaolin
doaj   +1 more source

The blood-tendon barrier: identification and characterisation of a novel tissue barrier in tendon blood vessels [PDF]

European Cells & Materials, 2016
Tissue barriers function as “gate keepers” between different compartments (usually blood and tissue) and are formed by specialised membrane-associated proteins, localising to the apicolateral plasma membrane domain of epithelial and endothelial cells. By
C Lehner, R Gehwolf, JC Ek, S Korntner, H Bauer, H-C Bauer, A Traweger, H Tempfer   +7 more
doaj   +1 more source

Eldecalcitol prevented OVX-induced osteoporosis through inhibiting BMSCs senescence by regulating the SIRT1-Nrf2 signal

Frontiers in Pharmacology, 2023
Background: Aging and oxidative stress are considered to be the proximal culprits of postmenopausal osteoporosis. Eldecalcitol (ED-71), a new active vitamin D derivative, has shown a good therapeutic effect on different types of osteoporosis, but the ...
Yuying Kou, Yuying Kou, Xing Rong, Xing Rong, Rong Tang, Rong Tang, Yuan Zhang, Yuan Zhang, Panpan Yang, Panpan Yang, Hongrui Liu, Hongrui Liu, Wanli Ma, Wanli Ma, Minqi Li, Minqi Li   +15 more
doaj   +1 more source