Results 91 to 100 of about 2,011,561 (382)
The emerging role of microRNAs in bone remodeling and its therapeutic implications for osteoporosis
Bioscience Reports, 2018 Osteoporosis, a common and multifactorial disease, is influenced by genetic factors and environments. However, the pathogenesis of osteoporosis has not been fully elucidated yet.
Qianyun Feng, Sheng Zheng, Jia Zheng
semanticscholar +1 more source
Interplay of integrins and selectins in metastasis
Molecular Oncology, EarlyView.Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva +2 more
wiley +1 more source
Aging Cell, 2018 Exosomes are secreted into the blood by various types of cells. These extracellular vesicles are involved in the contribution of exosomal proteins to osteoblastic or osteoclastic regulatory networks during the failure of bone remodeling, which results in
Yong Xie +5 more
semanticscholar +1 more source
Toughening and mechanosensing in bone: a perfectly balanced mechanism based on competing stresses [PDF]
arXiv, 2022 Bone is a stiff and though, hierarchical and continuously evolving material that optimizes its structure to respond to mechanical stimuli, which also govern growth and remodeling processes. However, a full understanding of the underlying mechanisms responsible for the cooperation of bone toughness and biological functions, with important implications ...
arxiv
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Physiological Bone Remodeling: Systemic Regulation and Growth Factor Involvement.
Physiology, 2016 Bone remodeling is essential for adult bone homeostasis. It comprises two phases: bone formation and resorption. The balance between the two phases is crucial for sustaining bone mass and systemic mineral homeostasis.
J. Siddiqui, N. Partridge
semanticscholar +1 more source
Does Porphyromonas gingivalis truly inhibit the oral carcinogenesis?
Molecular Oncology, EarlyView.Chen‐xi Li, Zhong‐cheng Gong
wiley +1 more source
Bone cells and the mechanisms of bone remodelling
Frontiers in Bioscience, 2012 Bone is a peculiar connective tissue which functionally interacts with many other organs and tissues, including bone marrow, lymphoid tissue, kidney, adipose tissue, endocrine pancreas, brain and gonads. Bone functions are accomplished by three principal cell types: the osteoblasts, cells of mesenchymal origin having osteogenic functions, the ...
Del Fattore, A., Teti, A., Rucci, N.
openaire +4 more sources
Mechanobiological regulation of bone remodeling -- Theoretical development of a coupled systems biology-micromechanical approach [PDF]
arXiv, 2012 Bone remodeling involves the coordinated removal of bone by osteoclasts and addition of bone by osteoblasts, a process that is modulated by the prevailing mechanical environment. In this paper a fully coupled model of bone remodeling is developed, based on coupling a bone cell population model with a micromechanical homogenization scheme of bone ...
arxiv
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source