Results 91 to 100 of about 338,869 (357)

Forskolin Enhances Urokinase Plasminogen Activator Secretion and Angiogenic Activity of Xeno‐Free Cultures of Human Adipose Tissue‐Derived Stem Cells

Advanced Biology, EarlyView.
The regenerative potential of adipose tissue‐derived stem cells can be enhanced through chemical stimulation in vitro. A short stimulation protocol using forskolin, either alone or in combination with other growth factors, under xeno‐free conditions enhanced the pro‐angiogenic responses in human ASCs.
Maria Vittoria Giraudo, Anne Therese Lauvrud, Rebecca Wiberg, Maria Brohlin, Gustav Andersson, Paul J Kingham   +5 more
wiley   +1 more source

Research progress on the effect and mechanism of immune cells on osteogenic differentiation of bone marrow mesenchymal stem cells

Kouqiang hemian waike zazhi
The role of bone marrow mesenchymal stem cells (BMSCs) in bone defect repair and bone regeneration has been extensively studied. Much evidence suggests that effective endogenous bone regeneration requires coordination of the immune system.
SHI Yan, GUO Hao, ZHENG Kaijuan, YANG Zhenming, QIANG Jinbiao, SHI Ce   +5 more
doaj   +1 more source

Reconstruction of Large Skeletal Defects: Current Clinical Therapeutic Strategies and Future Directions Using 3D Printing

Frontiers in Bioengineering and Biotechnology, 2020
The healing of bone fractures is a well-orchestrated physiological process involving multiple cell types and signaling molecules interacting at the fracture site to replace and repair bone tissue without scar formation.
Luciano Vidal, Carina Kampleitner, Meadhbh Á. Brennan, Meadhbh Á. Brennan, Alain Hoornaert, Alain Hoornaert, Pierre Layrolle   +6 more
doaj   +1 more source

Transient Local Bone Remodeling Effects of rhBMP-2 in an Ovine Interbody Spine Fusion Model [PDF]

, 2016
Background: Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a powerful osteoinductive morphogen capable of stimulating the migration of mesenchymal stem cells (MSCs) to the site of implantation and inducing the proliferation and ...
Badura, Jeffrey, Bae, Hyun W., Patel, Vikas V., Pradhan, Ben B., Sardar, Zeeshan M., Seim, Howard, Toth, Jeffrey M., Turner, Anthony S.   +7 more
core   +1 more source

Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum)

Advanced Biology, EarlyView.
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez, Nicolás Alcaraz, Karla Torres‐Arciga, José Antonio Ocampo‐Cervantes, Alejandra Cervera, Clementina Castro‐Hernández, Cynthia Gabriela Sámano‐Salazar, Ernesto Soto‐Reyes, Rodrigo González‐Barrios   +8 more
wiley   +1 more source

Interpretation of the WHO 2022 classification of head and neck tumours (5th Edition): The epithelial tumours of oral cavity and mobile tongue

Kouqiang hemian waike zazhi
The 5th edition of the Classification of Head and Neck Tumours by the World Health Organization (WHO) was published in March 2022. In the section on oral cavity and mobile tongue tumours, the classification of epithelial tumours in the 5th edition has ...
LI Jinwei, SHA Tong, ZHENG Kaijuan, NIE Mengdong, GUAN Weihang, SHI Ce   +5 more
doaj   +1 more source

Osteocytes as a record of bone formation dynamics: A mathematical model of osteocyte generation in bone matrix [PDF]

, 2014
The formation of new bone involves both the deposition of bone matrix, and the formation of a network of cells embedded within the bone matrix, called osteocytes.
Buenzli, Pascal R
core   +3 more sources

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Dual-Action flavonol carbonized polymer dots spray: Accelerating burn wound recovery through immune responses modulation and EMT induction

Materials Today Bio
Effective immune homeostasis modulation and re-epithelialization promotion are crucial for accelerating burn wound healing. Cell migration is fundamental to re-epithelialization, with epithelial-mesenchymal transition (EMT) as a key mechanism.
Liuyi Du, Xu Zhang, Lei Huang, Mingxi Yang, Wenbin Zhang, Jiaqi Xu, Junguang Liu, Wangni Xie, Xue Zhang, Kexuan Liu, Wenhao Zhai, Linlin Wen, Boya Zhang, Rongrong Ye, Lijun Liu, Huan Wang, Hongchen Sun, Daowei Li   +17 more
doaj   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source