Results 61 to 70 of about 2,247,449 (357)

JAK/STAT pathway and molecular mechanism in bone remodeling

Molecular Biology Reports, 2020
JAK/STAT signaling pathway is involved in many diseases, including autoimmune diseases, which are characterized by a close interconnection between immune and bone system.
E. Sanpaolo, C. Rotondo, D. Cici, A. Corrado, F. Cantatore   +4 more
semanticscholar   +1 more source

BMP9 Reduces Bone Loss in Ovariectomized Mice by Dual Regulation of Bone Remodeling

Journal of Bone and Mineral Research, 2020
Bone remodeling is dynamic and is tightly regulated through bone resorption dominated by osteoclasts and bone formation dominated by osteoblasts. Imbalances in this process can cause various pathological conditions, such as osteoporosis.
Yan‐man Zhou, Yu-ying Yang, Yixuan Jing, Tian-jiao Yuan, Li-hao Sun, B. Tao, Jian-min Liu, Hong-yan Zhao   +7 more
semanticscholar   +1 more source

Alendronate treatment results in similar levels of trabecular bone remodeling in the femoral neck and vertebra [PDF]

, 2009
Introduction Bone turnover suppression in sites that already have a low surface-based remodeling rate may lead to oversuppression that could have negative effects on the biomechanical properties of bone.
Allen, Matthew R., Burr, David B., Diab, Tamim   +2 more
core   +1 more source

Polyacrylamide-Sodium Alginate Hydrogel Releasing Oxygen and Vitamin C Promotes Bone Regeneration in Rat Skull Defects

Frontiers in Materials, 2021
Oxygen is essential for cell survival and tissue regeneration. Scaffolds releasing oxygen have been hypothesized as an ideal strategy for bone repair. However, excessive oxygen supply will disturb the redox balance, lead to oxidative stress, and affect ...
Bin Zhao, Bin Zhao, Jingya He, Jingya He, Feng Wang, Feng Wang, Ruxiao Xing, Ruxiao Xing, Bin Sun, Bin Sun, Yanmin Zhou, Yanmin Zhou   +11 more
doaj   +1 more source

Effect of oligonucleotide MT01 delivered by N-isopropylacrylamide modified polyethyleneimine for bone regeneration

Frontiers in Bioengineering and Biotechnology, 2023
Objective: This study aimed to investigate the regulatory effect of N-isopropylacrylamide-modified polyethyleneimine (PEN)-delivered oligodeoxynucleotide (ODN) MT01 on bone regeneration in vitro and in vivo.Methods: A polyethylenimine (PEI) derivative ...
Qian Zhang, Qian Zhang, Xingyuan Qu, Xingyuan Qu, Chen Liang, Chen Liang, Hongyan Li, Siyu Du, Siyu Du, Chang Wang, Chang Wang, Yuandong Xie, Yi Zheng, Lei Wang   +13 more
doaj   +1 more source

General analysis of mathematical models for bone remodeling

, 2010
Bone remodeling is regulated by pathways controlling the interplay of osteoblasts and osteoclasts. In this work, we apply the method of generalized modelling to systematically analyse a large class of models of bone remodeling.
Gross, Thilo, Siegmund, Stefan, Stiefs, Dirk, Zumsande, Martin   +3 more
core   +1 more source

Electron Microscopic Studying of Rat Bone Cells Under Microgravity Conditions [PDF]

, 2016
In the experiments on rats (SLS-2) with the use of electron microscopy there was made the study of the osteoclasts population and the peculiarities of resorptive processes in a spongy bone of the epiphyses and the iliac crest.The results of investigation
Polkovenko, O. (Olga)
core   +2 more sources

Skeletal Microdamage: Less About Biomechanics and More About Remodeling [PDF]

, 2008
The mechanical consequences of skeletal microdamage have been clearly documented using various experimental methods, yet recent experiments suggest that physiological levels of microdamage accumulation are not sufficient to compromise the bones ...
Allen, Matthew R., Burr, David B.
core   +1 more source

Research progress on the role and mechanism of miR-671 in bone metabolism and bone-related diseases

Frontiers in Oncology, 2023
Bone metabolism consists of bone formation and resorption and maintains a dynamic balance in vivo. When bone homeostasis is broken, it can manifest as osteoarthritis (OA), rheumatoid arthritis (RA), osteosarcoma (OS), etc.
Shaotai Wang, Shaotai Wang, Min Hu, Min Hu, Dongsheng Song, Dongsheng Song, Linjun Tang, Huan Jiang, Huan Jiang   +8 more
doaj   +1 more source

MicroRNAs in pulmonary arterial remodeling [PDF]

, 2013
Pulmonary arterial remodeling is a presently irreversible pathologic hallmark of pulmonary arterial hypertension (PAH). This complex disease involves pathogenic dysregulation of all cell types within the small pulmonary arteries contributing to vascular ...
A Courboulin, A Eulalio, A Ishisaki, A Jelaska, A Kos, A Sacconi, A Tanzer, A Zampetaki, A Zampetaki, AE Frost, AJ Tijsen, AM Walker, Andrew H. Baker, AR Kuhn, AS Flynt, AY Rangrez, AY Yu, B Wojciak-Stothard, BD Adams, BN Davis, BN Davis-Dusenbery, C Atkinson, C Li, C Sweeney, CA Klattenhoff, CD Cool, CL Bockmeyer, D Cifuentes, D Loffler, DB Badesch, DF Liao, DM Patrick, DP Bartel, E Hergenreider, E Mathe, E Rooij Van, ED Michelakis, FE Wang, G Lagna, G Meister, G Simonneau, G Song, GK Owens, H Beppu, H Kang, H Takahashi, H Tazawa, H Valadi, HY Chiang, J Brennecke, J Kim, J Liu, J Niu, J Ryan, J Sarkar, J Skog, J-S Yang, JD Arroyo, Jennifer S. Grant, JH Newman, JM Boucher, JR Thomson, K Abe, K Rakesh, K Wang, KA O’Donnell, KB Lane, KD Taganov, Kevin White, KN Cowan, KR Cordes, KR Stenmark, KR Stenmark, L Elia, L Guo, L He, L He, L Long, L Tu, LA Brennan, LR Frumkin, M Afrakhte, M Brock, M Das, M Deo, M Humbert, M Humbert, M Humbert, M Izikki, M Rabinovitch, M Trabucchi, M Xin, Margaret R. MacLean, MC Chan, MC Chan, MD Moen, MJ Goumans, MM Hoeper, N Liu, N Raver-Shapira, N Volk, NW Morrell, O Platoshyn, P Caruso, P Fasanaro, P Sklepkiewicz, R Kulshreshtha, R Kumarswamy, R Paulin, RD Machado, RJ Dekker, RM O’Connell, S Bonnet, S Chakravarthy, S Jalali, S Mizuno, S Sakamoto, S Sakao, S Yang, SA Moschos, SS Pullamsetti, T Boettger, T Thum, TC Chang, TX Lu, U Bruning, VN Parikh, W Shi, WB Li, X Huang, X Ji, X Long, X Yang, Y Cheng, Y Cheng, Y Ling, Y Liu, YL Jiang   +137 more
core   +2 more sources