Results 61 to 70 of about 338,869 (357)

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

Molecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho, Yubin Hah, Eunsik Yun, Hye In Ka, Aram Lee, Sora Han, Dawn Lee, Sung Wook Kim, Jong Hoon Park, Byung Su Kwon, Young Yang, Jongmin Kim   +11 more
wiley   +1 more source

Identification of cross-talk pathways and PANoptosis-related genes in periodontitis and Alzheimer’s disease by bioinformatics analysis and machine learning

Frontiers in Aging Neuroscience
Background and objectivesPeriodontitis (PD), a chronic inflammatory disease, is a serious threat to oral health and is one of the risk factors for Alzheimer’s disease (AD).
Xiantao Chen, Xiantao Chen, Yifei Dai, Yifei Dai, Yushen Li, Yushen Li, Jiajun Xin, Jiajun Xin, Jiatong Zou, Jiatong Zou, Rui Wang, Rui Wang, Hao Zhang, Hao Zhang, Zhihui Liu, Zhihui Liu   +15 more
doaj   +1 more source

Progenitor cells, bone marrow–derived fibrocytes and endothelial-to-mesenchymal transition: new players in vascular fibrosis [PDF]

, 2016
No abstract ...
Harvey, Adam, Lopes, Rheure A., Montezano, Augusto C., Rios, Francisco J., Touyz, Rhian   +4 more
core   +2 more sources

Retinoid Receptors in Bone and Their Role in Bone Remodeling [PDF]

Frontiers in Endocrinology, 2015
Vitamin A (retinol) is a necessary and important constituent of the body which is provided by food intake of retinyl esters and carotenoids. Vitamin A is known best for being important for vision, but in addition to the eye, vitamin A is necessary in numerous other organs in the body, including the skeleton. Vitamin A is converted to an active compound,
Petra eHenning, Howard Herschel Conaway, Ulf Holger Lerner, Ulf Holger Lerner   +3 more
openaire   +5 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Advances in mesenchymal stem cell conditioned medium-mediated periodontal tissue regeneration

Journal of Translational Medicine, 2021
Periodontitis is a chronic inflammatory disease that leads to the destruction of both soft and hard periodontal tissues. Complete periodontal regeneration in clinics using the currently available treatment approaches is still a challenge.
Hongbing Lin, Huishan Chen, Xuetao Zhao, Zhen Chen, Peipei Zhang, Yue Tian, Yawei Wang, Tong Ding, Lijing Wang, Yuqin Shen   +9 more
doaj   +1 more source

Bone functional remodeling under multi-field loadings [PDF]

, 2007
Bone remodeling process is investigated theoretically and numerically within the framework of the extended adaptive elasticity. The coupling between the internal and surface remodeling is considered for the solution of the bone remodeling process. A semi-
He, Xiaoqiao, Qin, Qing-Hua, Qu, Chuanyong   +2 more
core  

Materials for Biomedical Applications [PDF]

, 1998
This paper discusses two ceramic material systems for selective laser sintering (SLS) that are being developed for biomedical applications for use in repair of bone defects.
Aufdemorte, T. B., Barlow, J. W, Fox, W. C, Lee, G., Swain, L.D., Vail, N.K   +5 more
core   +1 more source

Deubiquitinating Enzymes and Bone Remodeling [PDF]

Stem Cells International, 2018
Bone remodeling, which is essential for bone homeostasis, is controlled by multiple factors and mechanisms. In the past few years, studies have emphasized the role of the ubiquitin-dependent proteolysis system in regulating bone remodeling. Deubiquitinases, which are grouped into five families, remove ubiquitin from target proteins and are involved in ...
Yu-chen Guo, Shi-wen Zhang, Quan Yuan
openaire   +4 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source