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Vaccination against Borna Disease: Overview, Vaccine Virus Characterization and Investigation of Live and Inactivated Vaccines [PDF]

Viruses, 2022
(1) Background: Vaccination of horses and sheep against Borna disease (BD) was common in endemic areas of Germany in the 20th century but was abandoned in the early 1990s.
Ralf Dürrwald, Jolanta Kolodziejek, Djin-Ye Oh, Sibylle Herzog, Heinrich Liebermann, Nikolaus Osterrieder, Norbert Nowotny   +6 more
doaj   +3 more sources

Impact of Borna Disease Virus Infection on the Transcriptome of Differentiated Neuronal Cells and Its Modulation by Antiviral Treatment [PDF]

Viruses, 2023
Borna disease virus (BoDV-1) is a highly neurotropic RNA virus that causes neurobehavioral disturbances such as abnormal social activities and memory impairment.
Da Teng, Keiji Ueda, Tomoyuki Honda
doaj   +2 more sources

Antagonistic activity against innate immunity determines virulence in mammalian bornaviruses [PDF]

npj Viruses
Variegated squirrel bornavirus 1 (VSBV-1) is a lethal emerging disease that has been discovered in privately owned and zoo squirrels, but its pathogenicity as a zoonotic pathogen remains uncertain.
Akiko Makino, Chiaki Tanaka, Kan Fujino, Keizo Tomonaga   +3 more
doaj   +2 more sources

BoDV-1 Infection in Children and Adolescents: A Systematic Review and Meta-Analysis [PDF]

Pediatric Reports, 2023
Borna disease virus 1 (BoDV-1) can cause a severe human syndrome characterized by meningo-myeloencephalitis. The actual epidemiology of BoDV-1 remains disputed, and our study summarized prevalence data among children and adolescents (
Matteo Riccò, Ilaria Zanella, Elia Satta, Silvia Ranzieri, Silvia Corrado, Federico Marchesi, Simona Peruzzi   +6 more
doaj   +2 more sources

Analysis of BoDV-1 status, EEG resting-state alpha activity and pro-inflammatory cytokines in adults with and without major depressive disorder [PDF]

Frontiers in Psychology
IntroductionIn severe cases, an infection with the Borna Disease Virus 1 (BoDV-1), the causative agent of Borna disease in horses, sheep, and other domestic mammals, was reported to be accompanied by cognitive dysfunctions, seizures, deep coma, or severe
Anna J. Torner, Bernhard T. Baune, Bernhard T. Baune, Bernhard T. Baune, Kristian Folta-Schoofs, Detlef E. Dietrich, Detlef E. Dietrich, Detlef E. Dietrich   +7 more
doaj   +2 more sources

Humane Infektionen mit dem Borna Disease Virus (BoDV-1) [PDF]

, 2018
Untersuchungen des Friedrich-Loeffler-Instituts (FLI) in Zusammenarbeit u.a. mit den Universitäts­kliniken in Regensburg, München und Leipzig identifizierten erstmals das klassische Bornavirus (Borna disease virus 1, BoDV-1; Spezies Mammalian 1 Bornavirus) als wahrscheinlichen Auslöser von schweren Entzündungen des Gehirns (Enzephalitis) beim Menschen.
Friedrich-Loeffler-Institut
core   +3 more sources

Bornavirus encephalitis shows a characteristic MR phenotype in humans [PDF]

Annals of Neurology, Volume 88, Issue 4, Page 723-735, October 2020., 2020
Objective The number of diagnosed fatal encephalitis in humans caused by the classical Borna disease virus (BoDV‐1) is increasingly recognized, ever since it was proven that BoDV‐1 can cause human infections.
Angstwurm, Klemens, Berlis, Ansgar, Bette, Stefanie, Bornavirus‐Encephalitis Study Group:, Dorn, Franziska, Finck, Tom, Holtmannspötter, Markus, Liesche‐Starnecker, Friederike, Maurer, Christoph, Probst, Monika, Rosati, Marco, Rubbenstroth, Dennis, Ruf, Viktoria, Schlegel, Jürgen, Wendl, Christina, Wiesinger, Isabel, Wiestler, Benedikt, Wunderlich, Silke, Zimmer, Claus   +18 more
core   +2 more sources

Spillover infections by rustrela virus, borna disease virus 1 and tick-borne encephalitis virus revealed by retrospective screening of mammalian encephalitis of unknown origin [PDF]

BMC Veterinary Research
Background Cross-species transmission of several viral neuropathogens may lead to fatal disease in incidental hosts. The newly discovered rustrela virus (RusV) as well as Borna disease virus 1 (BoDV-1), tick-borne encephalitis virus (TBEV), and highly ...
Anne Voss, Anne Günther, Olga Geit, Chloé Puget, Andreas Pauly, Karin Stiasny, Kore Schlottau, Martin Beer, Achim D. Gruber, Angele Breithaupt, Dennis Rubbenstroth, Lars Mundhenk   +11 more
doaj   +2 more sources

Mapping Bornavirus encephalitis-A comparative study of viral spread and immune response in human and animal dead-end hosts. [PDF]

PLoS Pathogens
Borna disease virus 1 (BoDV-1) has long been recognized as a cause of fatal encephalitis in animals and was only recently identified as a zoonotic pathogen causing a similar disease in humans.
Yannik Vollmuth, Nicola Jungbäck, Przemyslaw Grochowski, Tatiana Mögele, Leonhard Stark, Niku S Zarrabi, Jürgen Schlegel, Tina Schaller, Bruno Märkl, Kaspar Matiasek, Friederike Liesche-Starnecker   +10 more
doaj   +2 more sources

Risk factors for Borna disease virus 1 encephalitis in Germany – a case–control study [PDF]

Emerging Microbes and Infections, 2023
In 2018, Borna Disease Virus 1 (BoDV-1) was confirmed as a human zoonotic pathogen causing rare but fatal encephalitis in Germany. While diagnostic procedures and the clinical picture have been described, epidemiology remains mysterious.
Kirsten Pörtner, Hendrik Wilking, Christina Frank, Merle M. Böhmer, Klaus Stark, Dennis Tappe   +5 more
doaj   +2 more sources