Results 11 to 20 of about 10,670 (219)

Enhancement of dose distribution using tissue compensators in boron neutron capture therapy. [PDF]

J Appl Clin Med Phys
Abstract In BNCT for head and neck tumors delivered with a horizontal beam, the presence of missing tissue near the beam path can cause reduction in neutron fluence rate in adjacent tissue regions due to the loss of scattered neutrons. These regions are referred to as neutron depleted areas.
Sasaki A, Hu N, Nojiri M, Akita K, Yoshikawa S, Kohigashi Y, Nihei K, Aihara T, Takeno S, Yoshino Y, Tanaka H, Ono K.   +11 more
europepmc   +2 more sources

Development and dosimetric evaluation of a freely deformable ⁶Li-based neutron shield for boron neutron capture therapy. [PDF]

Med Phys
Abstract Background Boron neutron capture therapy (BNCT) enables selective tumor irradiation by exploiting the high‐linear energy transfer particles generated from neutron interactions with 10B atoms. BNCT has been approved as an insurance‐covered medical treatment for recurrent head and neck cancer in Japan.
Hu N, Kakino R, Sasaki A, Nojiri M, Akita K, Yoshikawa S, Kohigashi Y, Yoshino Y, Takeno S, Aihara T, Takata T, Tanaka H, Nihei K, Ono K.   +13 more
europepmc   +2 more sources

In vivo evaluation of the effects of combined boron and gadolinium neutron capture therapy in mouse models

Scientific Reports, 2022
While boron neutron capture therapy (BNCT) depends primarily on the short flight range of the alpha particles emitted by the boron neutron capture reaction, gadolinium neutron capture therapy (GdNCT) mainly relies on gamma rays and Auger electrons ...
Woonghee Lee, Kyung Won Kim, Jeong Eun Lim, Swarbhanu Sarkar, Jung Young Kim, Yongmin Chang, Jeongsoo Yoo   +6 more
doaj   +1 more source

Homocystamide Conjugates of Human Serum Albumin as a Platform to Prepare Bimodal Multidrug Delivery Systems for Boron Neutron Capture Therapy

Molecules, 2021
Boron neutron capture therapy is a unique form of adjuvant cancer therapy for various malignancies including malignant gliomas. The conjugation of boron compounds and human serum albumin (HSA)—a carrier protein with a long plasma half-life—is expected to
Tatyana Popova, Maya A. Dymova, Ludmila S. Koroleva, Olga D. Zakharova, Vladimir A. Lisitskiy, Valeria I. Raskolupova, Tatiana Sycheva, Sergei Taskaev, Vladimir N. Silnikov, Tatyana S. Godovikova   +9 more
doaj   +1 more source

Correlation between L‐amino acid transporter 1 expression and 4‐borono‐2‐18F‐fluoro‐phenylalanine accumulation in humans

Cancer Medicine, 2023
Background The correlation between L‐type amino acid transporter 1 (LAT1) expression and 4‐borono‐2‐18F‐fluoro‐phenylalanine (18F‐FBPA) accumulation in humans remains unclear.
Tairo Kashihara, Taisuke Mori, Tetsu Nakaichi, Satoshi Nakamura, Kimiteru Ito, Hiroaki Kurihara, Masahiko Kusumoto, Jun Itami, Seiichi Yoshimoto, Hiroshi Igaki   +9 more
doaj   +1 more source

Biological evaluation of a glucose-based boron carrier as a potential agent for boron neutron capture therapy. [PDF]

Int J Cancer
What's New? Boron neutron capture therapy (BNCT) is a targeted form of radiation therapy designed to selectively destroy cancer cells. BNCT is not widely used, however, owing in part to challenges involving selective boron delivery to tumors. The present study evaluated the potential of a novel glucoconjugate, 6‐O‐(o‐carboranylmethyl)‐d‐glucopyranose ...
Imlimthan S, Bahrami K, Pehkonen H, Centanni A, Montaser AB, Värä A, Matović J, Liljenbäck H, Auchynnikava T, Huttunen KM, Roivainen A, Airaksinen AJ, Ekholm FS, Monni O, Rautio J, Sarparanta M.   +15 more
europepmc   +2 more sources

Experimental study on Compton camera for boron neutron capture therapy applications

Scientific Reports, 2023
Boron neutron capture therapy (BNCT) is a high-dose-intensive radiation therapy that has gained popularity due to advancements in accelerator neutron sources.
M. Sakai, S. Tamaki, I. Murata, R. K. Parajuli, A. Matsumura, N. Kubo, M. Tashiro   +6 more
doaj   +1 more source

Boron Neutron Capture Therapy: Microdosimetry at Different Boron Concentrations

Applied Sciences, 2023
This paper explores the role of microdosimetry in boron neutron capture therapy (BNCT), a cancer treatment involving the selective accumulation of boron-containing compounds in cancer cells, followed by neutron irradiation.
Valeria Conte, Anna Bianchi, Anna Selva
doaj   +1 more source

Nanostructured boron agents for boron neutron capture therapy: a review of recent patents

Medical Review, 2023
Boron neutron capture therapy (BNCT) is a potential radiation therapy modality for cancer, and tumor-targeted stable boron-10 (10B) delivery agents are an important component of BNCT. Currently, two low-molecular-weight boron-containing compounds, sodium
Zhang Xiyin, Lin Yusheng, Hosmane Narayan S., Zhu Yinghuai   +3 more
doaj   +1 more source

Monte Carlo simulation of tilted contact plaque brachytherapy placement for juxtapapillary retinoblastoma

Radiation Oncology, 2022
Background The 106-Ruthenium contact plaque applicator is utilized for the treatment of intraocular tumor within a thickness of less than 6 mm. If anything obstructs the placement of the plaque applicator, the treatment is generally difficult because the
Satoshi Nakamura, Naoya Murakami, Shigenobu Suzuki, Kimiteru Ito, Mihiro Takemori, Hiroki Nakayama, Keita Kaga, Takahito Chiba, Kotaro Iijima, Kana Takahashi, Tomonori Goka, Jun Itami, Hiroyuki Okamoto, Hiroshi Igaki   +13 more
doaj   +1 more source