Results 41 to 50 of about 10,670 (219)

L-DOPA preloading increases the uptake of borophenylalanine in C6 glioma rat model: a new strategy to improve BNCT efficacy. [PDF]

, 2008
Purpose: Boron neutron capture therapy (BNCT) is a radiotherapeutic modality based on 10B(n,a)7Li reaction, for the treatment of malignant gliomas. One of the main limitations for BNCT effectiveness is the insufficient intake of 10B nuclei in the tumor ...
Bozzali, M, Cametti, C, Capuani, S, Colasanti, M, D'Amore, E, Gili, T, Lazzarino, G, Maraviglia, B, Pastore, Fs, Porcari, P, Russo, S, Venturini, G   +11 more
core   +1 more source

Correcting for the heterogeneous boron distribution in a tumor for BNCT dose calculation

Scientific Reports, 2023
Most treatment planning systems of boron neutron capture therapy perform dose calculations based on the assumption of a homogeneous boron distribution in tumors, which leads to dose distortion due to the difference between the tumor-to-normal tissue ...
Yi-Chiao Teng, Jiang Chen, Wan-Bing Zhong, Yuan-Hao Liu   +3 more
doaj   +1 more source

Neutron capture therapy with a new boron-porphyrin compound in the rat 9L glioma model [PDF]

, 1998
Neutron capture therapy with a new boron-porphyrin compound was tested in a rat brain tumor model . Although the concentration of boron in the tumor was too low to elicit a therapeutic effect, prominent histopathologic changes, such as necrosis ...
Hayakawa Y., Matsumura A., Nakagawa K., Nakajima S., Nose T., Ono K., Sakata I., Shibata Y., Yamamoto T., Yoshii Y., 柴田 靖   +10 more
core  

Taming the Immiscibility of Gold, Iron, and Boron to Craft Chemodegradable Nanoparticles for Multimodal Imaging and Radiotherapy

Advanced Healthcare Materials, EarlyView.
Over half of cancer patients undergo radiotherapy. Laser ablation enabled the synthesis of immiscible Au‐Fe‐B nanoparticles designed as degradable bimodal radiosensitizers for X‐ray radiotherapy (XRT), boron neutron capture therapy (BNCT), and bimodal imaging for X‐ray computed tomography (CT) and magnetic resonance imaging (MRI). These nanosensitizers
Michael Bissoli, Clara M.G. de Faria, Veronica Torresan, Maria Assunta Lacavalla, Mattia Cattelan, Denis Badocco, Paolo Pastore, Pasquina Marzola, Laura Cansolino, Cinzia Ferrari, Ian Postuma, Riccardo Vago, Silva Bortolussi, Antonello E. Spinelli, Daniel Forrer, Vincenzo Amendola   +15 more
wiley   +1 more source

A Study of the Production of Neutrons for Boron Neutron Capture Therapy using a Proton Accelerator [PDF]

, 2014
Boron Neutron Capture Therapy (BNCT) is a binary cancer therapy particularly well-suited to treating aggressive tumours that exhibit a high degree of infiltration of the surrounding healthy tissue. Such tumours, for example of the brain and lung, provide
Bennett, J.R.J., Edgecock, R., Green, S, Phoenix, B, Scott, MC   +4 more
core  

MAGIC polymer gel for dosimetric verification in boron neutron capture therapy [PDF]

, 2007
"Radiation-sensitive polymer gels are among the most promising three-dimensional dose verification tools developed to date. We tested the normoxic polymer gel dosimeter known by the acronym MAGIC (methacrylic and ascorbic acid in gelatin initiated by ...
Aschan, Auterinen, Auterinen, Chu, Chu, Deene, Deene, Farajollahi, Fong, Fransson, Gambarini, Gambarini, Gambarini, Gambarini, Gore, Gustavsson, Gustavsson, Gustavsson, Heufelder, Iiro Auterinen, International Commission on Radiation Units and Measurements (ICRU), Jirasek, Jouni Uusi-Simola, Kosunen, Low, Maryanski, Petri Kotiluoto, Press, Raaijmakers, Rae, Ramm, Rogus, Sami Heikkinen, Sauli Savolainen, Seppälä, Serén, Silva, Tiina Seppälä, Tom Serén, Uusi-Simola   +39 more
core   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, EarlyView.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

A method for delivering the required neutron fluence in an accelerator-based boron neutron capture therapy system employing a lithium target

Scientific Reports
Accelerator-based boron neutron capture therapy (BNCT) systems employing a solid-state lithium target indicated the reduction of neutron flux over the lifetime of a target, and its reduction could represent the neutron flux model.
Satoshi Nakamura, Mihiro Takemori, Tetsu Nakaichi, Yasunori Shuto, Tairo Kashihara, Kotaro Iijima, Takahito Chiba, Hiroki Nakayama, Yuka Urago, Shuka Nishina, Yuta Kobayashi, Hironori Kishida, Shoji Imamichi, Kana Takahashi, Mitsuko Masutani, Hiroyuki Okamoto, Teiji Nishio, Jun Itami, Hiroshi Igaki   +18 more
doaj   +1 more source

dosimetry methods in boron neutron capture therapy [PDF]

, 2014
Dosimetry studies have been carried out at thermal and epithermal columns of LVR- 15 research reactor for investigating the spatial distribution of gamma dose, fast neutron dose and thermal neutron fluence.
Dario Giove, Emanuele Artuso, Fabrizio Campi, Francesco d’Errico, Grazia Gambarini, Jiri Burian, Ladislav Viererbl, Luca Barcaglioni, Luisella Garlati, Marco Felisi, Marta Borroni, Mauro Carrara, Milan Marek, Stefano Giulini Castiglioni Agosteo, Veronica Regazzoni, Vit Klupak   +15 more
core  

Investigation of irradiation conditions for recurrent breast cancer in JRR-4 [PDF]

, 2011
Clinical trials of boron neutron capture therapy (BNCT) for recurrent breast cancers are considered at Japan Research Reactor No. 4 (JRR-4). In this study, the irradiation technique for a total mastectomy patient with recurrent cancer was optimized by ...
Horiguchi H., Kumada H., Nakamura T., Sagawa H., Suzuki M., Yanagie H., 熊田 博明   +6 more
core   +1 more source