Results 21 to 30 of about 6,117,045 (351)

Design and discovery of boronic acid drugs.

European journal of medicinal chemistry, 2020
Research related to boronic acids, from synthetic development to materials to drug discovery, has skyrocketed in the past 20 years. In terms of drug discovery, the incorporation of boronic acids into medicinal chemistry endeavours has seen a steady ...
J. Plescia, N. Moitessier
semanticscholar   +1 more source

Hydrogel Glucose Sensor with In Vivo Stable Fluorescence Intensity Relying on Antioxidant Enzymes for Continuous Glucose Monitoring

iScience, 2020
Summary: Hydrogel glucose sensors with boronic acid-based fluorescence intensity theoretically hold promise to improve in vivo continuous glucose monitoring (CGM) by facilitating long-lasting accuracy.
Jun Sawayama, Teru Okitsu, Akihiro Nakamata, Yoshihiro Kawahara, Shoji Takeuchi   +4 more
doaj   +1 more source

Advancing Glycan Analysis: A New Platform Integrating SERS, Boronic Acids, and Machine Learning Algorithms

Advanced Sensor Research, 2023
Glycans are the most abundant fundamental biomolecules, but profiling glycans is challenging due to their structural complexity. To address this, a novel glycan detection platform is developed by integrating surface‐enhanced Raman spectroscopy (SERS ...
Qiang Hu, Dacheng Kuai, Hyundo Park, Haley Clark, Perla B. Balbuena, Joseph Sang‐Il Kwon, Hung‐Jen Wu   +6 more
doaj   +1 more source

Boronic Acids as Prospective Inhibitors of Metallo-β-Lactamases: Efficient Chemical Reaction in the Enzymatic Active Site Revealed by Molecular Modeling

Molecules, 2021
Boronic acids are prospective compounds in inhibition of metallo-β-lactamases as they form covalent adducts with the catalytic hydroxide anion in the enzymatic active site upon binding.
Alexandra V. Krivitskaya, Maria G. Khrenova   +1 more
doaj   +1 more source

Electrophilic Trifluoromethylselenolation of Boronic Acids [PDF]

Molecules, 2017
Trifluoromethylselenylated compounds are emergent compounds with interesting physicochemical properties that still suffer from a lack of efficient synthetic methods. We recently developed an efficient one-pot strategy to generate in situ CF3SeCl and use it in various reactions.
Ghiazza, Clément, Tlili, Anis, Billard, Thierry   +2 more
openaire   +4 more sources

The Active Site Sulfenic Acid Ligand in Nitrile Hydratases Can Function as a Nucleophile [PDF]

, 2014
Nitrile hydratase (NHase) catalyzes the hydration of nitriles to their corresponding commercially valuable amides at ambient temperatures and physiological pH.
Holz, Richard C., Liu, Dali, Martinez, Salette, Sanishvili, Ruslan, Wu, Rui   +4 more
core   +3 more sources

Boronic acid with high oxidative stability and utility in biological contexts

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Like thiols, boronic acids are unstable to oxidation in biological contexts, limiting their utility. We discovered that the rate-limiting step in the oxidation of a boronic acid can be slowed by the installation of a pendant carboxyl group ...
B. Graham, I. Windsor, Brian Gold, Ronald T. Raines   +3 more
semanticscholar   +1 more source

Highly Diastereo- and Enantioselective Allylboration of Aldehydes using alpha-Substituted Allyl/Crotyl Pinacol Boronic Esters via in Situ Generated Borinic Esters [PDF]

, 2013
Readily available, alpha-substituted allyl/crotyl pinacol boronic esters often give low E/Z selectivity (with Z favored) in reactions with aldehydes. We found that addition of nBuLi to the pinacol boronic ester followed by trapping of the alkoxide with ...
Althaus M., Andersen M. W., Batey R. A., Batey R. A., Beckmann E., Blais J., Brown H. C., Brown H. C., Brown H. C., Brown H. C., Bubnov Y. N., Carosi L., Carosi L., Chemler S. R., Chen M., Chen M., Christine L. Willis, Cmrecki V., Cole T. E., Denmark S. E., Fang G. Y., Flamme E. M., Gonzalez A. Z., Guzman-Martinez A., Hancock K. G., Helen K. Scott, Hesse M. J., Hoffmann R. W., Hoffmann R. W., Hoffmann R. W., Hoffmann R. W., Hoffmann R. W., Hoffmann R. W., Ito H., Jack L.-Y. Chen, Kennedy J. W. J., Kister J., Kliman L. T., Kramer G. W., Lachance H., Larouche-Gauthier R., Matteson D. S., Matthew J. Hesse, Midland M. M., Park J. K., Pelz N. F., Peng F., Peng F., Pietruszka J., Pietruszka J., Posseme F., Pulis A., Ramachandran P. V., Shiner C. S., Sonawane R. P., Stymiest J. L., Varinder K. Aggarwal, Webster M. P., Woodward A. R., Yamamoto Y., Zschage O.   +60 more
core   +2 more sources

Boronic Acid-Based Electrochemical Sensors for Detection of Biomolecules

International Journal of Electrochemical Science, 2013
Boronic acids can form reversible covalent bonds with 1, 2- or 1, 3-diols to generate five or six-membered cyclic complexes. Thus, boronic acid functionalized compounds and materials have attracted much attention in both chemistry and biology as the ...
Lin Liu, Ning Xia, Yun Xing, Dehua Deng
doaj   +1 more source

Covalent adaptable networks using boronate linkages by incorporating TetraAzaADamantanes

Frontiers in Chemistry, 2023
Boronic esters prepared by condensation of boronic acids and diols have been widely used as dynamic covalent bonds in the synthesis of both discrete assemblies and polymer networks.
Simon van Hurne, Marijn Kisters, Maarten M. J. Smulders   +2 more
doaj   +1 more source