Results 61 to 70 of about 6,796 (188)

Activity of silver nanoparticles on prokaryotic cells and Bothrops jararacussu snake venom

Drug and Chemical Toxicology, 2018
Nanoparticle-conjugated venom-toxins of venomous animals and its therapeutic efficacy against emerging or neglecting diseases is a promising strategy. In this study, silver nanoparticles (AgNPs ∼50 nm, 0.081 mg mL−1) were studied against the neuromuscular blockade, myotoxic effects induced by Bothrops jararacussu venom (60 µg mL−1) and also against ...
Isadora Caruso Fontana Oliveira, Marina Oliveira de Paula, Hellen Cristine Boschilha Lastra, Bruno de Brito Alves, Débora Antunes Neto Moreno, Edson Hideaki Yoshida, Jorge Amaral Filho, José Carlos Cogo, Eliana Aparecida Varanda, Mahendra Rai, Carolina Alves dos Santos, Yoko Oshima-Franco   +11 more
openaire   +3 more sources

Exceptional Visual‐Opsin Coexpression and Phenotypic Diversity in Outer‐Retinal Photoreceptors of Caenophidian Snakes

Journal of Comparative Neurology, Volume 533, Issue 10, October 2025.
In snakes, profound differences in retinal architecture are observed between diurnal and nocturnal species. Additionally, in the rod‐dominated retinas of nocturnal snakes, coexpression of the cone opsins SWS1 and LWS in individual cones is common, while rhodopsin (RH1) is restricted to typical rods.
Einat Hauzman, Silke Haverkamp, Juliana H. Tashiro, Irene L. Gügel, Natalia F. Torello‐Viera, Thaís B. Guedes, Pavel Němec, Nicholas R. Casewell, Cassandra M. Modahl, Maria Ermelinda Oliveira, Ana Lúcia C. Prudente, Daniel O. Mesquita, Dora Fix Ventura, David J. Gower   +13 more
wiley   +1 more source

Crystallization and preliminary X-ray analysis of SIII-SPIII, a ahospholipase A2 isolated from the venom of Bothrops jararacussu

, 1998
Large single crystals have been obtained of SIII-SPIII, a phospholipase A2 from the venom of Bothrops jararacussu. The crystals belong to the orthorhombic system space group C222, and diffract X-rays to a resolution of 1.9 Å. Preliminary analysis reveals
Cintra, A. C O, Arni, Raghuvir K., De Azevedo Jr., Walter F., Ward, Richard J., Fontes, M. R M, Lombardi, F. R., Giglio, José R.   +6 more
core   +2 more sources

Oral Tolerance Induction by Bothrops jararaca Venom in a Murine Model and Cross-Reactivity with Toxins of Other Snake Venoms

Toxins, 2021
Oral tolerance is defined as a specific suppression of cellular and humoral immune responses to a particular antigen through prior oral administration of an antigen. It has unique immunological importance since it is a natural and continuous event driven
Lilian Rumi Tsuruta, Ana Maria Moro, Denise V. Tambourgi, Osvaldo Augusto Sant’Anna   +3 more
doaj   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, Volume 22, Issue 9, September 2025.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source

Bothrops snake venoms and their isolated toxins, an L-amino acid oxidase and a serine protease, modulate human complement system pathways

Journal of Venomous Animals and Toxins including Tropical Diseases, 2015
Background Activation of the complement system plays an important role in the regulation of immune and inflammatory reactions, and contributes to inflammatory responses triggered by envenomation provoked byBothrops snakes.
Lorena Rocha Ayres, Alex dos Reis Récio, Sandra Mara Burin, Juliana Campos Pereira, Andrea Casella Martins, Suely Vilela Sampaio, Fabíola Attié de Castro, Luciana Simon Pereira-Crott   +7 more
doaj   +1 more source

Snake venom toxins: Potential anticancer therapeutics

Journal of Applied Toxicology, Volume 44, Issue 5, Page 666-685, May 2024.
Abstract Snake venom contains a cocktail of compounds dominated by proteins and peptides, which make up the toxin. The toxin components of snake venom attack several targets in the human body including the neuromuscular system, kidney and blood coagulation system and cause pathologies. As such, the venom toxins can be managed and used for the treatment
Benedict C. Offor, Lizelle A. Piater
wiley   +1 more source

Neutralization of proteases from Bothrops snake venoms by the aqueous extract from Casearia sylvestris (Flacourtiaceae)

, 2001
Aqueous extract from Casearia sylvestris leaves, a typical plant from Brazilian open pastures, was able to neutralize the hemorrhagic activity caused by Bothrops asper, Bothrops jararacussu, Bothrops moojeni, Bothrops neuwiedi and Bothrops pirajai venoms.
Rucavado Romero, Alexandra, Borges, Márcia Helena, Soares, Andreimar Martins, Oliveira, Fábio de, Rodrigues, Veridiana De Melo, Franshesni, A. M., Homsi Brandeburgo, Maria Inës, Giglio, José Roberto   +7 more
core   +1 more source

The Protective Action of Coutarea hexandra (Rubiaceae) on the Neuromuscular Blockade Induced by Lachesis muta muta (Viperidae: Crotalinae) Venom

BioMed Research International, Volume 2024, Issue 1, 2024.
Envenomations by snakes represent a neglected health problem in tropical and subtropical countries. In South America, Lachesis muta occasionally causes severe human envenomation, with treatment being conditioned to an unspecific antivenom. In this work, we examined the neutralizing ability of Coutarea hexandra stem bark hydroalcoholic extract (Ch‐E ...
Grazielle D. Pilon, Anna P. Farias-de-França, Nathalia M. Cantuária, Magali G. Silva, Aline G. Leão-Torres, Rafael S. Floriano, Marcio G. dos Santos, Nelson Jorge da Silva Jr., Otto M. S. Gerlach, Valdir Cechinel-Filho, Yoko Oshima-Franco, Samuele Maramai   +11 more
wiley   +1 more source

An Isoflavone from Dipteryx alata Vogel is Active against the in Vitro Neuromuscular Paralysis of Bothrops jararacussu Snake Venom and Bothropstoxin I, and Prevents Venom-Induced Myonecrosis

Molecules, 2014
Snakebite is a neglected disease and serious health problem in Brazil, with most bites being caused by snakes of the genus Bothrops. Although serum therapy is the primary treatment for systemic envenomation, it is generally ineffective in neutralizing ...
Miriéle C. Ferraz, Edson H. Yoshida, Renata V.S. Tavares, José C. Cogo, Adélia C.O. Cintra, Cháriston A. Dal Belo, Luiz M. Franco, Márcio G. dos Santos, Flávia A. Resende, Eliana A. Varanda, Stephen Hyslop, Pilar Puebla, Arturo San Feliciano, Yoko Oshima-Franco   +13 more
doaj   +1 more source