Results 81 to 90 of about 6,796 (188)

Synthesis and evaluation of sesquiterpene lactone inhibitors of phospholipase A2 from Bothrops jararacussu

Toxicon, 2011
Several sesquiterpene lactone were synthesized and their inhibitive activities on phospholipase A(2) (PLA(2)) from Bothrops jararacussu venom were evaluated. Compounds Lac01 and Lac02 were efficient against PLA(2) edema-inducing, enzymatic and myotoxic activities and it reduces around 85% of myotoxicity and around 70% of edema-inducing activity.
Alvarenga, E. S. de, Silva, S. A., Barosa, L. C. A., Demuner, A. J., Parreira, A. G., Ribeiro, R. I. M. A., Marcussi, S., Ferreira, J. M. S., Resende, R. R., Granjeiro, P. A., Silva, J. A., Soares, A. M., Marangoni, S., Silva, S. L. da   +13 more
openaire   +3 more sources

Effect of heparin and antivenom on skeletal muscle damage produced by Bothrops jararacussu venom.

Histology and histopathology, 2002
We examined the effect of treatment with heparin and polyvalent antivenom on mice muscle Extensor digitorum longus (EDL) regeneration, after damage induced by injection of Bothrops jararacussu crude venom over the muscle of the right posterior limb. The mice were separated into groups and each group received treatment, by intravenous route with either ...
Calil-Elias, S., Martinez, A.M.B., Melo, P.A.   +2 more
openaire   +3 more sources

Primary Structure Characterization Of Bothrops Jararacussu Snake Venom Lectin.

, 2015
The complete amino acid sequence of the lectin from Bothrops jararacussu snake venom (BJcuL) is reported. The sequence was determined by Edman degradation and amino acid analysis of the S-carboxymethylated BJcuL derivative (RC-BJcuL) and from its ...
de Carvalho, Daniela D, Marangoni, Sergio, Novello, José C   +2 more
core  

Acidente por serpentes do gênero Bothrops: série de 3.139 casos

Revista da Sociedade Brasileira de Medicina Tropical, 1997
Em avaliação dos prontuários médicos de 3.139 pacientes picados por serpentes do gênero Bothrops atendidos no Hospital Vital Brazil (HVB), de 1981 a 1990, observou-se maior acometimento do sexo masculino (75,7%).
Lindioneza Adriano Ribeiro, Miguel Tanús Jorge   +1 more
doaj   +1 more source

Acute local nerve lesions induced by Bothrops jararacussu snake venom

, 2015
Myonecrosis is one of the most common effects of Bothrops jararacussu venom, but little is known about the action of this venom on other tissues. In this study, we used transmission electron microscopy to examine the influence of B.
Santo Neto, H, Queiroz, LD, Marques, MJ
core   +1 more source

Neutralization of pharmacological and toxic activities of Bothrops jararacussu snake venom and isolated myotoxins by Serjania erecta methanolic extract and its fractions

Journal of Venomous Animals and Toxins including Tropical Diseases, 2011
Most of the snakebites recorded in Brazil are caused by the Bothrops genus. Given that the local tissue damage caused by this genus cannot be treated by antivenom therapy, numerous studies are focusing on supplementary alternatives, such as the use of ...
RS Fernandes, TR Costa, S Marcussi, CP Bernardes, DL Menaldo, II Rodriguéz Gonzaléz, PS Pereira, AM Soares   +7 more
doaj   +1 more source

Crystallization and preliminary X-ray analysis of S-III-SPIII, a phospholipase A2 isolated from the venom of Bothrops jararacussu.

, 2014
Large single crystals have been obtained of S-III-SPIII, a phospholipase A(2) from the venom of Bothrops jararacussu. The crystals belong to the orthorhombic system space group C222, and diffract X-rays to a resolution of 1.9 Angstrom.
Fontes, MRM, Arni, R. K., Ward, R. J., Lombardi, F. R., de Azevedo, W. F., Cintra, ACO, Giglio, JR   +6 more
core  

Pulsed ultrasound therapy accelerates the recovery of skeletal muscle damage induced by Bothrops jararacussu venom

Brazilian Journal of Medical and Biological Research, 2012
We studied the effect of pulsed ultrasound therapy (UST) and antibothropic polyvalent antivenom (PAV) on the regeneration of mouse extensor digitorum longus muscle following damage by Bothrops jararacussu venom.
J. Saturnino-Oliveira, M.A. Tomaz, T.F. Fonseca, G.A. Gaban, M. Monteiro-Machado, M.A. Strauch, B.L. Cons, S. Calil-Elias, A.M.B. Martinez, P.A. Melo   +9 more
doaj   +2 more sources

Immunome and venome of Bothrops jararacussu: a proteomic approach to study the molecular immunology of snake toxins

, 2010
A combination of anti-bothropic and anti-crotalic sera has been reported to be more effective in neutralizing the effects of Bothrops jararacussu venom than anti-bothropic serum alone. The role of proteins from B.
De Simone, Salvatore Giovanni, Foguel, Debora, Correa Netto, Carlos, Araujo, Ricardo Teixeira, Zingali, Russolina Benedeta, Melgarejo, Aníbal Rafael, Soares, Márcia Regina, Aguiar, Aniesse Silva, Carlos Correa-Netto, Russolina Benedeta Zingali, Márcia Regina Soares, Salvatore Giovanni De-Simone, Ricardo Teixeira-Araujo, Aníbal Rafael Melgarejo, Debora Foguel, Aniesse Silva Aguiar   +15 more
core   +1 more source

Biochemical and structural investigations of Bothropstoxin-II, a myotoxic Asp49 phospholipase A(2) from Bothrops jararacussu venom

, 2008
Bothropstoxin-II a calcium-dependent enzyme from Bothrops jararacussu venom causes tissue damage and several haemostatic disorders including platelet aggregation.
Arni, Raghuvir K., Melo, Paulo A., Arruda, Emerson Z., Lourenzoni, Marco R., Tomaz, Marcelo A., Vicoti, Magno M., Abrego, Jose R. B., Murakami, Mario T.   +7 more
core   +1 more source