Balance Between Order and Disorder: Quantum-Epigenetic Pathways for the Emergence and Continuous Evolution of Life. [PDF]
Casotti MC +18 more
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From Mechanistic Models to AI Synergy: A Roadmap for Predictive and Personalized Biology. [PDF]
Huang L +9 more
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SEGUID v2: Extending SEGUID checksums for circular, linear, single- and double-stranded biological sequences. [PDF]
Pereira H +6 more
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A side-by-side biophysical comparison of five single-domain antibody scaffolds used for synthetic display libraries. [PDF]
Rauschmayer M +6 more
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Genomic Features, Functional Complementarity, and the Potential for Constructing Synthetic Consortia from Dominant Petroleum-Degrading Bacteria. [PDF]
Zhang F +9 more
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The axonal transport velocity of prions is independent of prion formation. [PDF]
Koshy SM +6 more
europepmc +1 more source
Bottom-Up Synthetic Biology: Engineering in a Tinkerer’s World
How synthetic can “synthetic biology” be? A literal interpretation of the name of this new life science discipline invokes expectations of the systematic construction of biological systems with cells being built module by module—from the bottom up.
Petra Schwille
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Bottom-Up Synthetic Biology Using Cell-Free Protein Synthesis
2023Technical advances in biotechnology have greatly accelerated the development of bottom-up synthetic biology. Unlike top-down approaches, bottom-up synthetic biology focuses on the construction of a minimal cell from scratch and the application of these principles to solve challenges.
Ke, Yue +5 more
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Mastering Complexity: Towards Bottom-Up Construction of Multifunctional Eukaryotic Synthetic Cells
Bottom-up synthetic biology thrives in reverse-engineering a particular biological function using a minimal set of molecular components, like purified proteins.
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