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Current Opinion in Chemical Biology, 2014
For more than half a century chemists have searched for a plausible prebiotic synthesis of RNA. The initial advances of the 1960s and 1970s were followed by decades of measured progress and a growing pessimism about overcoming remaining challenges.
Brian J, Cafferty, Nicholas V, Hud
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For more than half a century chemists have searched for a plausible prebiotic synthesis of RNA. The initial advances of the 1960s and 1970s were followed by decades of measured progress and a growing pessimism about overcoming remaining challenges.
Brian J, Cafferty, Nicholas V, Hud
openaire +2 more sources
Designer proteins for bottom-up synthetic biology
2017This chapter discusses recent developments in sub- and extra-cellular biological systems assembled from designer polypeptides. Artificial and semi-designed extracellular matrices and viruses are described from the perspective of bottom-up synthetic biology and protein-inspired fabrication.
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Toward low-cost biomanufacturing through in vitro synthetic biology: bottom-up design
Journal of Materials Chemistry, 2011While most in vitro synthetic biology projects are usually used for the purposes of basic science research or the formation of high-value products, cell-free synthetic pathway biotransformation (SyPaB), which can implement complicated biochemical reactions by the in vitro assembly of numerous enzymes and coenzymes, would be used for low-cost ...
Y.-H. Percival Zhang +4 more
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Minimal Phagocyte: A bottom-up synthetic biology approach to studying phagocytosis
Within the intricate landscape of immunology, the captivating cellular process of engulfing external objects, known as phagocytosis, has sparked scientific interest for several decades. This essential process, how for example macrophages devour and engulf bacteria, not only fuels the imagination, but also represents our first line of defense against ...openaire +2 more sources
Introducing computational protein optimisation and design to bottom-up synthetic biology
Researchers in the field of bottom-up synthetic biology aim to gain insights into the fundamental principles of biology via the creation of so-called synthetic cells, human-made minimal biological entities that mimic certain aspects of life. The core idea is to strip the basic unit of biology, the cell, down to its simplest possible implementation ...openaire +1 more source
Can Bottom-Up Synthetic Biology Generate Advanced Drug-Delivery Systems?
Trends in Biotechnology, 2021Oskar Staufer +2 more
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Semi-Synthetic Artemisinin: A Model for the Use of Synthetic Biology in Pharmaceutical Development
Nature Reviews Microbiology, 2014Jesus F. Barajas, Christopher J Paddon
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Realizing the Potential of Synthetic Biology
Nature Reviews Molecular Cell Biology, 2014George Church +2 more
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A Brief History of Synthetic Biology
Nature Reviews Microbiology, 2014James J. Collins +2 more
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