Results 121 to 130 of about 379 (143)
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BOTULINUM ANTITOXIN AS A THERAPEUTIC AGENT IN MONKEYS WITH EXPERIMENTAL BOTULISM
1965Abstract : Antitoxin administered soon after the appearance of the first toxic signs in monkeys given 2.5 to 5.0 LD50's of botulinum toxin resulted in complete recovery in 11 out of 15 animals when liquid food and fluids were forced during the period of aphagia. When no supportive treatment was applied, only one out of six survived.
Michael J. House +3 more
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Biochimie, 2010
Concern about the malicious applications of botulinum neurotoxin has highlighted the need for a new generation of safe and highly potent antitoxins. In this study, we developed and evaluated the preclinical pharmacology and safety of a new F(ab')₂ antitoxin against botulinum neurotoxin serotype A (BoNT/A).
Yun-Zhou, Yu +11 more
openaire +2 more sources
Concern about the malicious applications of botulinum neurotoxin has highlighted the need for a new generation of safe and highly potent antitoxins. In this study, we developed and evaluated the preclinical pharmacology and safety of a new F(ab')₂ antitoxin against botulinum neurotoxin serotype A (BoNT/A).
Yun-Zhou, Yu +11 more
openaire +2 more sources
Preparation, measurement and possible use of human antitoxin againstCl. botulinum A, B, and E toxins
Medical Microbiology and Immunology, 1975Human antibodies against botulinum toxins A, B, and E have been raised by repeated injections of pentavalent toxoid in a healthy volunteer. The final titer was 3.2 U anti-A, 0.4 U anti-B, and 2.5 U anti-E/ml. In mice, the efficacy of the antitoxin decreases with the time between poisoning and application of the antiserum.
E, Habermann, S, Bernáth
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DURATION OF PASSIVE IMMUNITY TO BOTULINUM TOXIN OFFERED BY ANTITOXIN IN MICE AND RABBITS
1965Abstract : Various doses of botulinum antitoxin, types A and B, were administered to mice and rabbits by the intraperitoneal and intravenous routes. The persistence of a passive immunity to the type A toxin was determined by (1) administering challenge doses of the toxin at various times after the antitoxin and (2) determining the median lethal ratios (
Fred W. Oberst +2 more
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Archivum immunologiae et therapiae experimentalis, 1977
Two groups of subjects were immunized with combined vaccine containing aluminum hydroxide-adsorbed botulinum toxoids, types A, B, and E, and 4 mld of formaldehyde-inactivated V. cholerae Inaba and Ogawa organisms. The first group included laboratory workers who were previously immunized against cholera and had professional contact with botulinum toxins
A, Galazka +2 more
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Two groups of subjects were immunized with combined vaccine containing aluminum hydroxide-adsorbed botulinum toxoids, types A, B, and E, and 4 mld of formaldehyde-inactivated V. cholerae Inaba and Ogawa organisms. The first group included laboratory workers who were previously immunized against cholera and had professional contact with botulinum toxins
A, Galazka +2 more
openaire +1 more source