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Infant botulism in Australia: availability of human botulinum antitoxin for treatment [PDF]

open access: yesMedical Journal of Australia, 2010
We report the first Australian case of treatment of infant botulism with a human botulinum antitoxin developed in the United States by the California Department of Public Health. Our patient's clinical improvement was rapid, and although the product is expensive, cost-analysis supports the economical viability of its use.
May, M. L. A.   +2 more
openaire   +5 more sources
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Antitoxin therapy for botulinum intoxication

Reviews in Medical Microbiology, 2001
Botulinum toxin is the most toxic substance known to mankind. It is involved in infant botulism, classical food-borne botulism, wound botulism, and is a threat in biological warfare or bioterrorism.
Carl N. Mayers   +2 more
exaly   +2 more sources

Anomalous enhancement of botulinum toxin type A neurotoxicity in the presence of antitoxin

Toxicon, 2001
The neutralization of botulinum toxin serotype A with polyclonal equine antitoxin was studied in isolated mouse hemidiaphragms and compared to the same action in live mice. The biological activity of the toxin in the isolated muscle could be markedly reduced with excess antitoxin, estimated as 3:1 molar ratios of IgG Ab:toxin or better.
R E Sheridan, S S Deshpande
exaly   +3 more sources

Development and evaluation of candidate vaccine and antitoxin against botulinum neurotoxin serotype F

Clinical Immunology, 2010
To produce a vaccine suitable for human use, a recombinant non His-tagged isoform of the Hc domain of botulinum neurotoxin serotype F (rFHc) was expressed in Escherichia coli and purified by sequential chromatography. The rFHc was evaluated as a subunit vaccine candidate in mouse model of botulism.
Yunzhou Yu, Wei-Yuan Yu, Zhi-Wei Sun
exaly   +3 more sources

Retrospective survey to evaluate the safety and efficacy of Japanese botulinum antitoxin therapy in Japan

Toxicon, 2016
Japanese botulinum antitoxins have been used for more than 50 years; however, their safety and therapeutic efficacy are not clear. In order to analyze the available data on botulinum antitoxin therapy in Japan, we surveyed published reports about botulism cases in which botulinum antitoxins were used, and retrospectively analyzed the safety and ...
Yasushi Torii   +2 more
exaly   +3 more sources

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