Results 161 to 170 of about 33,694 (186)
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BOTULINUM ANTITOXIN AS A THERAPEUTIC AGENT IN MONKEYS WITH EXPERIMENTAL BOTULISM
1965Abstract : Antitoxin administered soon after the appearance of the first toxic signs in monkeys given 2.5 to 5.0 LD50's of botulinum toxin resulted in complete recovery in 11 out of 15 animals when liquid food and fluids were forced during the period of aphagia. When no supportive treatment was applied, only one out of six survived.
Michael J. House +3 more
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Early local antitoxin intervention attenuates botulinum neurotoxin-induced neuromuscular dysfunction
ToxiconBotulinum neurotoxin type A (BoNT/A) is widely used in clinical practice; however, unintended diffusion to non-target muscles can result in functional impairments, including eyelid ptosis and abnormal facial movements. Currently, no pharmacological strategies are available, and management is largely limited to passive observation.
Shenjia Fan +5 more
openaire +2 more sources
DURATION OF PASSIVE IMMUNITY TO BOTULINUM TOXIN OFFERED BY ANTITOXIN IN MICE AND RABBITS
1965Abstract : Various doses of botulinum antitoxin, types A and B, were administered to mice and rabbits by the intraperitoneal and intravenous routes. The persistence of a passive immunity to the type A toxin was determined by (1) administering challenge doses of the toxin at various times after the antitoxin and (2) determining the median lethal ratios (
Fred W. Oberst +2 more
openaire +1 more source
1973
Abstract : In order to study prolonged recovery times, mice were injected via the intramuscular route with sublethal concentrations of botulinum type A toxin. Proteolytic enzyme solutions were injected into the test site to determine if the removal of bound proteinacious toxin from neuromuscular junctions could influence paralytic recovery times ...
openaire +1 more source
Abstract : In order to study prolonged recovery times, mice were injected via the intramuscular route with sublethal concentrations of botulinum type A toxin. Proteolytic enzyme solutions were injected into the test site to determine if the removal of bound proteinacious toxin from neuromuscular junctions could influence paralytic recovery times ...
openaire +1 more source