Results 151 to 160 of about 1,891 (175)
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BOTULINUM ANTITOXIN AS A THERAPEUTIC AGENT IN MONKEYS WITH EXPERIMENTAL BOTULISM
1965Abstract : Antitoxin administered soon after the appearance of the first toxic signs in monkeys given 2.5 to 5.0 LD50's of botulinum toxin resulted in complete recovery in 11 out of 15 animals when liquid food and fluids were forced during the period of aphagia. When no supportive treatment was applied, only one out of six survived.
Michael J. House +3 more
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In vitro assays for botulinum toxin and antitoxins.
Developments in biological standardization, 1987Clostridium botulinum produces several powerful neuroparalytic toxins which, although rare in food-poisoning instances, are generally fatal. A considerable amount of effort has therefore been made by the food industry to ensure that food treatment processes adequate to prevent growth and toxin production by Cl. botulinum.
C, Shone +6 more
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Anti‐immunoglobulin Responses to IgG, F(ab′)2, and Fab Botulinum Antitoxins in Mice
Immunopharmacology and Immunotoxicology, 2003Side effects to botulinum antitoxins, including anaphylaxis and serum sickness, are common. This is due to the immunogenicity of the antitoxin, which can be measured by the production of anti-immunoglobulin antibodies. An ideal botulinum antitoxin would elicit a minimal production of anti-immunoglobulin antibodies from a patient, aiding its safety.
Carl N, Mayers +3 more
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Toxicon, 2016
Japanese botulinum antitoxins have been used for more than 50 years; however, their safety and therapeutic efficacy are not clear. In order to analyze the available data on botulinum antitoxin therapy in Japan, we surveyed published reports about botulism cases in which botulinum antitoxins were used, and retrospectively analyzed the safety and ...
Keita, Mottate +9 more
openaire +2 more sources
Japanese botulinum antitoxins have been used for more than 50 years; however, their safety and therapeutic efficacy are not clear. In order to analyze the available data on botulinum antitoxin therapy in Japan, we surveyed published reports about botulism cases in which botulinum antitoxins were used, and retrospectively analyzed the safety and ...
Keita, Mottate +9 more
openaire +2 more sources
1973
Abstract : In order to study prolonged recovery times, mice were injected via the intramuscular route with sublethal concentrations of botulinum type A toxin. Proteolytic enzyme solutions were injected into the test site to determine if the removal of bound proteinacious toxin from neuromuscular junctions could influence paralytic recovery times ...
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Abstract : In order to study prolonged recovery times, mice were injected via the intramuscular route with sublethal concentrations of botulinum type A toxin. Proteolytic enzyme solutions were injected into the test site to determine if the removal of bound proteinacious toxin from neuromuscular junctions could influence paralytic recovery times ...
openaire +1 more source
Archivum immunologiae et therapiae experimentalis, 1977
Two groups of subjects were immunized with combined vaccine containing aluminum hydroxide-adsorbed botulinum toxoids, types A, B, and E, and 4 mld of formaldehyde-inactivated V. cholerae Inaba and Ogawa organisms. The first group included laboratory workers who were previously immunized against cholera and had professional contact with botulinum toxins
A, Galazka +2 more
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Two groups of subjects were immunized with combined vaccine containing aluminum hydroxide-adsorbed botulinum toxoids, types A, B, and E, and 4 mld of formaldehyde-inactivated V. cholerae Inaba and Ogawa organisms. The first group included laboratory workers who were previously immunized against cholera and had professional contact with botulinum toxins
A, Galazka +2 more
openaire +1 more source