Results 11 to 20 of about 83,600 (312)
Regulatory Networks Controlling Neurotoxin Synthesis in Clostridium botulinum and Clostridium tetani
Toxins, 2022 Clostridium botulinum and Clostridium tetani are Gram-positive, spore-forming, and anaerobic bacteria that produce the most potent neurotoxins, botulinum toxin (BoNT) and tetanus toxin (TeNT), responsible for flaccid and spastic paralysis, respectively ...
Michel R. Popoff, Holger Brüggemann
doaj +2 more sources
Therapy of Sialorrhea with Botulinum Neurotoxin [PDF]
Neurology and Therapy, 2019 Botulinum neurotoxin (BoNT) is considered the treatment of choice for various symptoms and diseases such as focal dystonia and focal spasticity. The effects of BoNT on the salivary glands have also been known for years, but their use was limited because ...
W. Jost +7 more
semanticscholar +5 more sources
Novel Anatomical Proposal for Botulinum Neurotoxin Injection Targeting Lateral Canthal Rhytids
Toxins, 2022 Botulinum neurotoxin injections near the lateral canthal rhytids are commonly used in cosmetic settings; however, there is a lack of thorough anatomical knowledge, and an effective way to treat them with accumulating knowledge is needed.
Kyu-Ho Yi +5 more
doaj +2 more sources
Anatomical Proposal for Botulinum Neurotoxin Injection for Glabellar Frown Lines
Toxins, 2022 Botulinum neurotoxin injection for treating glabellar frown lines is a commonly used method; however, side effects, such as ptosis and samurai eyebrow, have been reported due to a lack of comprehensive anatomical knowledge.
Kyu-Ho Yi +3 more
doaj +2 more sources
Novel Anatomical Guidelines on Botulinum Neurotoxin Injection for Wrinkles in the Nose Region
Toxins, 2022 Botulinum neurotoxin injection surrounding the nose area is frequently used in aesthetic settings. However, there is a shortage of thorough anatomical understanding that makes it difficult to treat wrinkles in the nose area. In this study, the anatomical
Kyu-Ho Yi +3 more
doaj +2 more sources
Botulinum Neurotoxin for the Treatment of Neuropathic Pain
Frontiers in Neurology, 2020 Botulinum neurotoxin is widely used for the treatment of central and peripherical neurological conditions. Initially used to treat strabismus, over the years its use has been expanded also to spasticity and other neurological disorders.
Gabriella Egeo +3 more
doaj +2 more sources
Acta Pharmacologica Sinica, 2023 Botulinum neurotoxin A ameliorates reserpine-induced depressive behaviors. Complement activation is involved in the reserpine-induced mouse model. Botulinum neurotoxin A reverses spine loss and reduced synapse density.
Yang Li +9 more
semanticscholar +1 more source
On Botulinum Neurotoxin Variability [PDF]
mBio, 2015 ABSTRACT The rapidly growing number of botulinum neurotoxin sequences poses the problem of the possible evolutionary significance of the variability of these superpotent neurotoxins for toxin-producing Clostridium species. To progress in the understanding of this remarkable phenomenon, we suggest that researchers should (i) abandon an anthropocentric ...
MONTECUCCO, CESARE +1 more
openaire +5 more sources
Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity
Science, 2021 Moving targets of neurotoxins Proteases that cleave protein targets at specific sequences control many biological functions. The ability to reprogram proteases to cleave new sequences of our choosing would enable new therapeutic and biotechnological ...
T. Blum +10 more
semanticscholar +1 more source
Botulinum and Tetanus Neurotoxins [PDF]
Annual Review of Biochemistry, 2019 Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins. They contain three functional domains responsible for receptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synaptic ...
Min Dong +3 more
openaire +4 more sources