Results 31 to 40 of about 83,600 (312)

CRISPR/Cas9-Mediated Genomic Deletion of the Beta-1, 4 N-acetylgalactosaminyltransferase 1 Gene in Murine P19 Embryonal Carcinoma Cells Results in Low Sensitivity to Botulinum Neurotoxin Type C. [PDF]

PLoS ONE, 2015
Botulinum neurotoxins produced by Clostridium botulinum cause flaccid paralysis by inhibiting neurotransmitter release at peripheral nerve terminals. Previously, we found that neurons derived from the murine P19 embryonal carcinoma cell line exhibited ...
Kentaro Tsukamoto, Chikako Ozeki, Tomoko Kohda, Takao Tsuji   +3 more
doaj   +1 more source

Centrally mediated late motor recovery after botulinum toxin injection: Case reports and a review of current evidence

Journal of Rehabilitation Medicine, 2017
Objective: Botulinum neurotoxin is commonly utilized in neurorehabilitation as a treatment for focal spasticity. Clinical experience has yielded observations of late motor recovery after intramuscular injection of botulinum neurotoxin, that are not ...
Manuel F. Mas, Sheng Li, Gerard E. Francisco   +2 more
doaj   +1 more source

Two-component signal transduction system CBO0787/CBO0786 represses transcription from botulinum neurotoxin promoters in Clostridium botulinum ATCC 3502.

PLoS Pathogens, 2013
Blocking neurotransmission, botulinum neurotoxin is the most poisonous biological substance known to mankind. Despite its infamy as the scourge of the food industry, the neurotoxin is increasingly used as a pharmaceutical to treat an expanding range of ...
Zhen Zhang, Hannu Korkeala, Elias Dahlsten, Elina Sahala, John T Heap, Nigel P Minton, Miia Lindström   +6 more
doaj   +1 more source

Molecular Aspects of Secretory Granule Exocytosis by Neurons and Endocrine Cells [PDF]

, 1994
Neuronal communication and endocrine signaling are fundamental for integrating the function of tissues and cells in the body. Hormones released by endocrine cells are transported to the target cells through the circulation.
Ahnert-Hilger G., Ahnert-Hilger G., Bader M. F., Baumert M., Bittner M. A., Bittner M. A., Bittner M. A., Blasi J., Elferink L. A., Fischer G., Geppert M., Halpern J. L., Hess S. D., Jahn R., MANFRED GRATZL, Marqueze-Pouey B., McMahon H. T., Schiavo G., Schiavo G., Schiavo G., Schmidle T., Shirataki H., Shoji-Kasai Y., Stecher B., Thomas L., Trimble W. S., Walch-Solimena C., Wright J. F., Yoshida A.   +28 more
core   +1 more source

Neuronal selectivity of botulinum neurotoxins

Toxicon, 2020
Botulinum neurotoxins (BoNTs) are highly potent toxins responsible for a severe disease, called botulism. They are also efficient therapeutic tools with an increasing number of indications ranging from neuromuscular dysfunction to hypersecretion syndrome, pain release, depression as well as cosmetic application.
Poulain, Bernard, Lemichez, Emmanuel, Popoff, Michel   +2 more
openaire   +4 more sources

Zebrafish Sensitivity to Botulinum Neurotoxins [PDF]

Toxins, 2016
Botulinum neurotoxins (BoNT) are the most potent known toxins. The mouse LD50 assay is the gold standard for testing BoNT potency, but is not sensitive enough to detect the extremely low levels of neurotoxin that may be present in the serum of sensitive animal species that are showing the effects of BoNT toxicity, such as channel catfish affected by ...
Kamalakar Chatla, Patricia Gaunt, Lora Petrie-Hanson, Lorelei Ford, Larry Hanson   +4 more
openaire   +3 more sources

Structure of dual receptor binding to botulinum neurotoxin B [PDF]

, 2014
Botulinum neurotoxins are highly toxic, and bind two receptors to achieve their high affinity and specificity for neurons. Here we present the first structure of a botulinum neurotoxin bound to both its receptors.
Berntsson, Ronnie P-A, Dong, Min, Peng, Lisheng, Stenmark, Pål   +3 more
core   +1 more source

The Action of Botulinum Toxin A on the Sternocleidomastoid Muscle: An Experimental Study on Rats

The Scientific World Journal, 2022
In this study, we aim to investigate the effective dose of botulinum neurotoxin A that results in paralysis of the sternocleidomastoid muscle for a minimum duration of 28 days in Wistar rats.
Themistoklis Vampertzis, Christina Barmpagianni, Chrysa Mpekiari, Rania Baka, Ioannis Zervos, Eleftherios Tsiridis, Nikiforos Galanis   +6 more
doaj   +1 more source

Phage lysin that specifically eliminates Clostridium botulinum Group I cells

Scientific Reports, 2020
Clostridium botulinum poses a serious threat to food safety and public health by producing potent neurotoxin during its vegetative growth and causing life-threatening neuroparalysis, botulism.
Zhen Zhang, Meeri Lahti, François P. Douillard, Hannu Korkeala, Miia Lindström   +4 more
doaj   +1 more source

Antiepileptic Effects of Botulinum Neurotoxin E [PDF]

The Journal of Neuroscience, 2005
Experimental studies suggest that the delivery of antiepileptic agents into the seizure focus might be of potential utility for the treatment of focal-onset epilepsies. Botulinum neurotoxin E (BoNT/E) causes a prolonged inhibition of neurotransmitter release after its specific cleavage of the synaptic protein synaptosomal-associated protein of 25 kDa ...
Costantin L, Bozzi Y, Richichi C, Viegi A, Antonucci F, Funicello M, Gobbi M, Mennini T, Rossetto O, Montecucco C, Maffei L, Vezzani A, Caleo M   +12 more
openaire   +7 more sources