Results 41 to 50 of about 24,922 (273)

Exploring the functional domain and the target of the tetanus toxin light chain in neurohypophysial terminals [PDF]

, 1994
The tetanus toxin light chain blocks calcium induced vasopressin release from neurohypophysial nerve terminals. Here we show that histidine residue 233 within the putative zinc binding motif of the tetanus toxin light chain is essential for the ...
Binz, T., Dayanithi, G., Gratzl, Manfred, Höhne-Zell, B., Niemann, H., Stecher, B., Weller, U., Yamasaki, S.   +7 more
core   +1 more source

An Integrative Approach to Computational Modelling of the Gene Regulatory Network Controlling Clostridium botulinum Type A1 Toxin Production [PDF]

, 2016
Clostridium botulinum produces botulinum neurotoxins (BoNTs), highly potent substances responsible for botulism. Currently, mathematical models of C.
Barker, Gary C., Ihekwaba, Adaoha E. C., Mura, Ivan, Peck, Michael W., Walshaw, John   +4 more
core   +2 more sources

Application of Botulinum Neurotoxin Injections in TRAM Flap for Breast Reconstruction: Intramuscular Neural Arborization of the Rectus Abdominis Muscle

Toxins, 2021
Breast reconstruction after mastectomy is commonly performed using transverse rectus abdominis myocutaneous (TRAM) flap. Previous studies have demonstrated that botulinum neurotoxin injections in TRAM flap surgeries lower the risk of necrosis and allow ...
Kyu-Ho Yi, Hyung-Jin Lee, Ji-Hyun Lee, Kyle K. Seo, Hee-Jin Kim   +4 more
doaj   +1 more source

A pragmatic harm reduction approach to manage a large outbreak of wound botulism in people who inject drugs, Scotland 2015 [PDF]

, 2018
Background People who inject drugs (PWID) are at an increased risk of wound botulism, a potentially fatal acute paralytic illness. During the first 6 months of 2015, a large outbreak of wound botulism was confirmed among PWID in Scotland, which resulted ...
Amanda Weir, Andrew McAuley, CC McGuigan, CN Ramsay, Corinne Amar, D Akbulut, DJ Passaro, E MacDonald, E Tweed, European Centre for Disease Prevention and Control, Gauri Godbole, Gillian Penrice, GY Chang, Health Protection Scotland, Information Services Division (ISD), J McLauchlin, J Sobel, J Strang, JA Jones, JA Stoltz, K Alpers, K Dunleavy, Kathie Grant, Kirsten M. A. Trayner, Kirsty Roy, M Desai, M Harris, M Ragonnet-Cronin, M Schroeter, MG Booth, N Markwick, National Records of Scotland, NE Palmateer, Public Health England, Health Protection Scotland, Public Health Wales, and Public Health Agency Northern Ireland, RJ Gordon, SB Werner, Scottish Government, Scottish Health Protection Network, SJ Hahné, SR Offerman, TN Wenham, VD Hope, VD Hope, Y Soukup-Baljak   +43 more
core   +1 more source

Positional Relationship Between the Orbicularis Oculi and Zygomaticus Complex Muscles by Ultrasonography: New Anatomical Insights for Crow's Feet Injection

Clinical Anatomy, EarlyView.
ABSTRACT The orbicularis oculi muscle (OOc) is strongly associated with facial aging as its contraction causes the formation of crow's feet. Botulinum neurotoxin (BoNT) injection is a representative treatment targeting muscle. The aim of this study was to demonstrate the anatomical relationship between the OOc and the zygomaticus complex muscles, and ...
Jiong‐Zhen Piao, Ji‐Hyun Lee, Kyung‐Seok Hu, Hee‐Jin Kim   +3 more
wiley   +1 more source

Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins. [PDF]

, 2020
Botulinum neurotoxin (BoNT) is one of the most acutely lethal toxins known to humans, and effective treatment for BoNT intoxication is urgently needed. Single-domain antibodies (VHH) have been examined as a countermeasure for BoNT because of their high ...
Jin, Rongsheng, Lam, Kwok-Ho, McNutt, Patrick M, Ondeck, Celinia, Perry, Kay, Shoemaker, Charles B, Tremblay, Jacqueline M, Vazquez-Cintron, Edwin, Webb, Robert P   +8 more
core  

A Novel Patient‐Specific Landmark‐Guided Approach for Intramuscular Botulinum Neurotoxin Injections Into the Rotator Cuff: A Cadaveric Study

Clinical Anatomy, EarlyView.
ABSTRACT Myofascial pain syndrome (MFPS) causes chronic shoulder pain. Supraspinatus and infraspinatus, rotator cuff muscles innervated by the suprascapular nerve, are commonly affected. Intramuscular botulinum neurotoxin (BoNT) injections near motor points (i.e., visible nerve branch entry sites used as a proxy for motor endplates) are an effective ...
Dave Osinachukwu Duru, David Kwan Ryung Lee, Gavin E. Jarvis, Niel Kang, Salma Chaudhury, Cecilia Brassett   +5 more
wiley   +1 more source

Role of Diagnostic Nerve Blocks in the Goal-Oriented Treatment of Spasticity with Botulinum Toxin Type A: A Case–Control Study

Toxins
The goal-setting process is pivotal in managing patients with disabling spasticity. This case–control study assessed the role of diagnostic nerve blocks in guiding the goal-setting process within goal-targeted treatment of spasticity with botulinum ...
Mirko Filippetti, Stefano Tamburin, Rita Di Censo, Martina Adamo, Elisa Manera, Jessica Ingrà, Elisa Mantovani, Salvatore Facciorusso, Marco Battaglia, Alessio Baricich, Andrea Santamato, Nicola Smania, Alessandro Picelli   +12 more
doaj   +1 more source

Cost minimization analysis of BoNT-As in the treatment of upper limb spasticity and cervical dystonia [PDF]

, 2016
Botulinum toxin type A (BoNT-A) injections are recommended for the management of upper limb spasticity (ULS) and cervical dystonia (CD). The main aim of this cost minimization analysis (CMA) was to compare the annual cost per patient for three BoNT-As ...
Bartolomei, Luigi, Bentivoglio, Anna Rita, Bizzarini, Massimo, Caglioni, Patrizia Maria, Cerbarano, Luana, Frontoni, Marco, Lus, Giacomo, Majorana, Giovanni, Nassetti, Stefania Alessandra, Osio, Maurizio, Ravasio, Roberto, Ravenni, Roberta, Santoro, Antonio, Smania, Nicola, Torlizzi, Flavia, Valvo, Sebastiana Claudia   +15 more
core   +1 more source

Botulinum Neurotoxin: The Ugly Duckling [PDF]

European Neurology, 2009
This review presents a brief account of the most significant biological effects and clinical applications of botulinum neurotoxins, in a way comprehensive even for casual readers who are not familiar with the subject. The most toxic known substances in botulinum neurotoxins are polypeptides naturally synthesized by bacteria of the genus <i> ...
openaire   +3 more sources