Results 51 to 60 of about 83,600 (312)

Botulinum neurotoxins are zinc proteins.

Journal of Biological Chemistry, 1992
The available amino acid sequences of 150-kDa botulinum and tetanus neurotoxins show the presence of a closely homologous segment in the middle of the light chain (NH2-terminal 50 kDa), which is the intracellularly active portion of the toxin. This segment contains the zinc binding motif of metalloendopeptidases, HEXXH.
Schiavo G., ROSSETTO, ORNELLA, Santucci A., DasGupta B. R., MONTECUCCO, CESARE   +4 more
openaire   +5 more sources

Clostridium botulinum Type E Toxins Bind to Caco-2 Cells by a Different Mechanism from That of Type A Toxins [PDF]

, 2012
Cultured Clostridium botulinum strains produce progenitor toxins designated as 12S, 16S, and 19S toxins. The 12S toxin consists of a neurotoxin (NTX, 7S) and a non-toxic non-hemagglutinin (NTNH).
Ma, Shaobo, Nengah Dwi Fatmawati, Ni, Oguma, Keiji, Suzuki, Tomonori, Yamamoto, Yumiko, Yokota, Kenji, Zhang, Kai   +6 more
core   +1 more source

Pharmacology of Botulinum Neurotoxin Serotype A

American Journal of Health-System Pharmacy, 2004
An historical perspective on the discovery and development of botulinum neurotoxin for commercial use, the differences between various botulinum toxin serotypes and commercially available products, and the structure, mechanism of action, pharmacologic effects, and immunogenicity of botulinum toxin type A are discussed.Botulinum toxin was discovered ...
Richard Wenzel
openalex   +3 more sources

Association of Laryngeal Dystonia With Common Neurologic Disorders

The Laryngoscope, EarlyView.
ABSTRACT Objective Laryngeal dystonia is a heterogenous disorder consisting of involuntary spasms of laryngeal muscles. There are multiple forms including adductor, abductor, and mixed phenotypes. The disorder is thought to be multifactorial, with various reported associations with family history of dystonia or movement disorders.
Brandon LaBarge, F. Jeffrey Lorenz, John P. Gniady   +2 more
wiley   +1 more source

Camelid VHHs Fused to Human Fc Fragments Provide Long Term Protection Against Botulinum Neurotoxin A in Mice

Toxins, 2019
The bacterium Clostridium botulinum is the causative agent of botulism—a severe intoxication caused by botulinum neurotoxin (BoNT) and characterized by damage to the nervous system. In an effort to develop novel C.
S. A. Godakova, A. N. Noskov, I. D. Vinogradova, G. A. Ugriumova, A. Solovyev, I. Esmagambetov, A. Tukhvatulin, D. Logunov, B. Naroditsky, D. Shcheblyakov, A. Gintsburg   +10 more
semanticscholar   +1 more source

Botulinum Neurotoxin: The Ugly Duckling [PDF]

European Neurology, 2009
This review presents a brief account of the most significant biological effects and clinical applications of botulinum neurotoxins, in a way comprehensive even for casual readers who are not familiar with the subject. The most toxic known substances in botulinum neurotoxins are polypeptides naturally synthesized by bacteria of the genus <i> ...
openaire   +3 more sources

Structural Basis of Botulinum Toxin Type F Binding to Glycosylated Human SV2A: In Silico Studies at the Periphery of a Lipid Raft

Biomolecules, 2022
Botulinum neurotoxins are the deadliest microbial neurotoxins in humans, with a lethal dose of 1 ng/kg. Incidentally, these neurotoxins are also widely used for medical and cosmetic purposes.
Fodil Azzaz, Didier Hilaire, Jacques Fantini   +2 more
doaj   +1 more source

Laryngeal Vibration to Treat Abductor‐Type Laryngeal Dystonia: Effectiveness and Cortical Response

The Laryngoscope, EarlyView.
In this study, people with abductor‐type laryngeal dystonia wore a collar with small, embedded vibrators. After vibrating the skin above the Adam's apple for 24 min, two‐thirds of participants thought their voice had noticeably improved, and objective measures of voice documented improvements in 45% of participants.
Arash Mahnan, Jiapeng Xu, Jinseok Oh, Divya Bhaskaran, Yang Zhang, Peter J. Watson, Jürgen Konczak   +6 more
wiley   +1 more source

Role of Diagnostic Nerve Blocks in the Goal-Oriented Treatment of Spasticity with Botulinum Toxin Type A: A Case–Control Study

Toxins
The goal-setting process is pivotal in managing patients with disabling spasticity. This case–control study assessed the role of diagnostic nerve blocks in guiding the goal-setting process within goal-targeted treatment of spasticity with botulinum ...
Mirko Filippetti, Stefano Tamburin, Rita Di Censo, Martina Adamo, Elisa Manera, Jessica Ingrà, Elisa Mantovani, Salvatore Facciorusso, Marco Battaglia, Alessio Baricich, Andrea Santamato, Nicola Smania, Alessandro Picelli   +12 more
doaj   +1 more source

Clinical Relevance of Botulinum Toxin Immunogenicity [PDF]

, 2012
Botulinum toxin type A is a 150 kD protein produced by Clostridium botulinum, which exists in a complex with up to six additional proteins. The ability of botulinum toxin to inhibit acetylcholine release at the neuromuscular junction has been exploited ...
Reiner Benecke
core   +1 more source