Results 61 to 70 of about 83,600 (312)
How do I Know That the Jerks I See Are Tics?
Movement Disorders Clinical Practice, EarlyView.Tics are prevalent hyperkinesias that are most often encountered in the context of a primary tic disorder, as in Tourette syndrome. Although their recognition is typically straightforward, they often share some phenomenological features with other jerky hyperkinesias and may be mislabeled as such.
Talyta Grippe +2 more
wiley +1 more source
Synaptotagmin Binding to Botulinum Neurotoxins
Biochemistry, 2019 Botulinum neurotoxins (BoNTs) are exceptionally toxic proteins that cause paralysis but are also extensively used as treatment for various medical conditions. Most BoNTs bind two receptors on neuronal cells, namely, a ganglioside and a protein receptor.
Pål Stenmark +7 more
openaire +5 more sources
Speech Differences between Multiple System Atrophy and Parkinson's Disease
Movement Disorders Clinical Practice, EarlyView.Abstract Background Delineation of Parkinson's disease (PD) from multiple system atrophy (MSA) can be challenging in early disease stages. Speech characteristics have been studied as digital biomarkers in PD and ataxias. Currently, data on speech in MSA is limited.
Tom Hähnel +9 more
wiley +1 more source
Science Advances, 2019 We report the preclinical characterization of two engineered botulinum neurotoxin serotype B proteins with significant therapeutic potential. Although botulinum neurotoxin serotype A (BoNT/A) products are common treatments for various disorders, there is
M. Elliott +18 more
semanticscholar +1 more source
Botulinum neurotoxin A, blinding, and bias [PDF]
Developmental Medicine & Child Neurology, 2019 This article is commented on by Day on page 159 of this issue.
Tandy Hastings‐Ison, Kerr Graham
openaire +4 more sources
Botulinum Neurotoxin Serotypes Detected by Electrochemical Impedance Spectroscopy
Toxins, 2015 Botulinum neurotoxin is one of the deadliest biological toxins known to mankind and is able to cause the debilitating disease botulism. The rapid detection of the different serotypes of botulinum neurotoxin is essential for both diagnosis of botulism and
Alison C. Savage +3 more
doaj +1 more source
A Cell Line for Detection of Botulinum Neurotoxin Type B [PDF]
, 2017 Botulinum neurotoxins (BoNTs) type A and type B are commonly used as biopharmaceutics for neurological diseases, uniquely allowing months-long paralysis of target muscles.
Adler +35 more
core +2 more sources
Movement Disorders Clinical Practice, EarlyView.ABSTRACT Background DaxibotulinumtoxinA (DAXI), a novel botulinum neurotoxin (BoNT) formulation, was shown to be safe, effective, and long‐lasting in the treatment of cervical dystonia (CD) over one treatment cycle in the phase 3, randomized, placebo‐controlled ASPEN‐1 trial.
Peter McAllister +11 more
wiley +1 more source
Why Are Botulinum Neurotoxin-Producing Bacteria So Diverse and Botulinum Neurotoxins So Toxic?
Toxins, 2019 Botulinum neurotoxins (BoNTs) are the most lethal toxins among all bacterial, animal, plant and chemical poisonous compounds. Although a great effort has been made to understand their mode of action, some questions are still open.
B. Poulain, M. Popoff
semanticscholar +1 more source
Myoclonic Dystonia: A Common Phenomenology in the Pleomorphic Movements of Angelman Syndrome
Movement Disorders Clinical Practice, EarlyView.Abstract Background Angelman syndrome (AS) is a neurodevelopmental disorder characterized by developmental delay, intellectual disability, a sociable demeanor, and abnormal movements. People with AS often exhibit multiple types of abnormal movements, including nonepileptic myoclonus, tremor, and dystonia, which hamper attempts to identify phenomenology
Robert P. Carson +8 more
wiley +1 more source