Results 81 to 90 of about 24,922 (273)

rAAV expressing recombinant neutralizing antibody for the botulinum neurotoxin type A prophylaxis [PDF]

, 2022
Artem A. Derkaev, E. I. Ryabova, I. B. Esmagambetov, Dmitry V. Shcheblyakov, Svetlana A. Godakova, I. D. Vinogradova, A. N. Noskov, Denis Y. Logunov, Boris S. Naroditsky, Gintsburg Al   +9 more
openalex   +1 more source

Wound botulism in injectors of drugs: upsurge in cases in England during 2004. [PDF]

, 2005
Wound infections due to Clostridium botulinum were not recognised in the UK and Republic of Ireland before 2000. C. botulinum produces a potent neurotoxin which can cause paralysis and death. In 2000 and 2001, ten cases were clinically recognised, with a
Akbulut, D, de Souza-Thomas, L, Dennis, J, Gent, M, Grant, KA, Hope, V, McLauchlin, J, Mithani, V, Mpamugo, O, Ncube, F, Ohai, C   +10 more
core   +1 more source

Gastroenterological disorders and hepatic disease in adults with cerebral palsy: A systematic review

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To describe the incidence, prevalence, and prognostic factors for gastroenterological disorders and hepatic disease in adults with cerebral palsy (CP), and to examine the effectiveness of any screening or interventions. Method Six databases were searched for articles published in any language since 1990 meeting eligibility criteria ...
Christina M. Marciniak, Jennifer M. Ryan, Alejandra Camacho‐Soto, Emily Capellari, Jessica Burke, Maram Sofiany, Zoë Post, Eric C. Sung, Michael D. Brown, the Adult Cerebral Palsy Clinical Practice Guidelines Working Group, Jennifer M Ryan, Rachel Byrne, Emily Capellari, Donna Riccio Omichinski, Mark Peterson, Jan Willem Gorter, Ashley Harris Whaley, Christine Imms, Christina M. Marciniak   +18 more
wiley   +1 more source

Arrangement of the Clostridium baratii F7 toxin gene cluster with identification of a σ factor that recognizes the botulinum toxin gene cluster promoters.

PLoS ONE, 2014
Botulinum neurotoxin (BoNT) is the most poisonous substances known and its eight toxin types (A to H) are distinguished by the inability of polyclonal antibodies that neutralize one toxin type to neutralize any of the other seven toxin types.
Nir Dover, Jason R Barash, Julianne N Burke, Karen K Hill, John C Detter, Stephen S Arnon   +5 more
doaj   +1 more source

SAMCEP Society consensus on the treatment of upper facial lines with botulinum neurotoxin type A: A tailored approach [PDF]

, 2023
F Braccini, Isabelle Catoni, F. Belfkira, Jacques Lagier, Emmanuel Roze, J. Paris, James Huth, V. Bronsard, Hugues Cartier, Mengel David, O. Galatoire, D. Obadia, H. Sabatier, E. Sarfati, Philippe Kestemont, Cécile Winter, Alessio Redaelli   +16 more
openalex   +1 more source

Microscopic and molecular aspects of skeletal muscle alterations in cerebral palsy

Developmental Medicine &Child Neurology, EarlyView.
Cerebral palsy, caused by non‐progressive brain injury, is frequently accompanied by skeletal muscle alterations. This review synthesizes current evidence from muscle biopsy studies, revealing cellular and molecular adaptations in muscle tissue. Abstract Cerebral palsy (CP), the most prevalent childhood‐onset motor disability, frequently entails ...
Sebastian Edman, Oscar Horwath, Eva Pontén, Sudarshan Dayanidhi, Ferdinand von Walden   +4 more
wiley   +1 more source

Therapeutic Uses and Efficacy of Botulinum Toxin in Orofacial Medicine: A Dental Perspective

Toxins
Botulinum neurotoxin (BoNT) is the exotoxin of Clostridium botulinum, a Gram-positive, spore-forming bacterium [...]
Kazuya Yoshida, Merete Bakke
doaj   +1 more source

Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination Against Botulinum C and D Neurotoxins. [PDF]

, 2019
Botulism is caused by botulinum neurotoxin (BoNT), the most poisonous substance known. BoNTs are also classified as Tier 1 biothreat agents due to their high potency and lethality.
Cobb, Ronald R, Conrad, Fraser, Espinoza, Yero, Garcia-Rodriguez, Consuelo, Kimbler, Angie, Kraus, Carl N, Marks, James D, Martinez, Zachary, Pham, Khanh, Riling, Kathryn, Snow, Doris M, Tomic, Milan T, Wong, David   +12 more
core  

Botulinum-A toxin injections into the detrusor muscle decrease nerve growth factor bladder tissue levels in patients with neurogenic detrusor overactivity [PDF]

, 2006
Purpose: We investigated the effects of BTX-A on visceral afferent nerve transmission by measuring bladder tissue NGF levels in patients with neurogenic detrusor overactivity before and after intravesical treatment with BTX-A.
Bini, V, Di Stasi, SM, Giannantoni, A, Goracci, G, Macchioni, L, Nardicchi, V, Porena, M, Zucchi, A   +7 more
core   +1 more source

Botulinum neurotoxins are zinc proteins.

Journal of Biological Chemistry, 1992
The available amino acid sequences of 150-kDa botulinum and tetanus neurotoxins show the presence of a closely homologous segment in the middle of the light chain (NH2-terminal 50 kDa), which is the intracellularly active portion of the toxin. This segment contains the zinc binding motif of metalloendopeptidases, HEXXH.
Schiavo G., ROSSETTO, ORNELLA, Santucci A., DasGupta B. R., MONTECUCCO, CESARE   +4 more
openaire   +4 more sources