The Journal of Physiology, EarlyView.Abstract figure legend Using wild‐type and Trpv1−/− rats, we assessed the contribution of TRPV1 channels to the activation of afferent renal nerve activity (ARNA) during renal artery occlusion, graded reductions in renal blood flow and elevated renal pelvic pressure.
Jacob B. Sullivan +2 more
wiley +1 more source
Ecotin-Like ISP ofL. majorPromastigotes Fine-Tunes Macrophage Phagocytosis by Limiting the Pericellular Release of Bradykinin from Surface-Bound Kininogens: A Survival Strategy Based on the Silencing of Proinflammatory G-Protein Coupled Kinin B2and B1Receptors [PDF]
, 2014 Erik Svensjö +4 more
openalex +1 more source
Impact of Endothelial Diversity and Dysfunction on Cardiovascular Disease
Comprehensive Physiology, Volume 15, Issue 6, December 2025.The vascular endothelium is highly diverse, regulating permeability, vascular tone, repair, and inter‐organ communication. Endothelial heterogeneity supports tissue‐specific needs, but dysfunction drives cardiovascular disease. Transcriptomics, in vitro models, and redox signaling studies reveal therapeutic targets for precision treatment of ...
Anna E. Williams +6 more
wiley +1 more source
Glucose elevations alter bradykinin-stimulated intracellular calcium accumulation in cultured endothelial cells [PDF]
, 1997 Galen M. Pieper, Lynn A Dondlinger
openalex +1 more source
Mechanisms That Prevent Vascular Leakage During Leukocyte Extravasation
Acta Physiologica, Volume 241, Issue 12, December 2025.ABSTRACT Background Inflammation is the response of the immune system against harmful stimuli in tissues. Leukocyte extravasation or TransEndothelial Migration (TEM) is a crucial step during inflammation, in which leukocytes migrate over the endothelial barrier toward the damaged tissue.
Siem J. de Haan, Jaap D. van Buul
wiley +1 more source
Cardiovascular Safety of VIAN‐c4551, an Antiangiogenic Peptide Derived From Vasoinhibin
Drug Development Research, Volume 86, Issue 7, November 2025.ABSTRACT Vasoinhibin is a potent antiangiogenic protein that blocks the activation of endothelial nitric oxide synthase (eNOS) in response to vascular endothelial growth factor, bradykinin, and acetylcholine (ACh). In this regard, VIAN‐c4551, a new synthetic vasoinhibin analog, has therapeutic potential for targeting angiogenesis in oncology and ...
Miguel A. García‐González +13 more
wiley +1 more source
Acta Physiologica, Volume 241, Issue 11, November 2025.ABSTRACT Aim To elucidate the molecular mechanism of cold sensing by visceral sensory endings, a side‐by‐side characterization of cold‐sensitive (CS) neurons in adult mouse trigeminal (TG) and vagal ganglia (VG) was performed. Methods A combination of physiological, pharmacological, molecular, and genetic tools was employed on trigeminal and vagal ...
Katharina Gers‐Barlag +4 more
wiley +1 more source
Cyanide Beyond Toxicity: A Systematic Review of Its Effects on Vascular Function
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 5, November 2025.ABSTRACT Cyanide is widely recognized for its potent toxicity, yet evidence shows that concentrations below 1 μM may enhance cytochrome c oxidase activity and have a regulatory function. Recent findings also demonstrate that mammalian cells, including endothelial cells, produce cyanide endogenously, where it can modulate mitochondrial bioenergetics ...
Elif Alan‐Albayrak, Ulf Simonsen
wiley +1 more source
Effect of chronic angiotensin converting enzyme inhibition on angiotensin I and bradykinin metabolism in rats [PDF]
, 1999 Leonilda Stanziola
openalex +1 more source