Duplications of KIAA1549 and BRAF screening by Droplet Digital PCR from formalin-fixed paraffin-embedded DNA is an accurate alternative for KIAA1549-BRAF fusion detection in pilocytic astrocytomas [PDF]
, 2018 Pilocytic astrocytomas represent the most common glioma subtype in young patients and account for 5.4% of all gliomas. They are characterized by alterations in the RAS–MAP kinase pathway, the most frequent being a tandem duplication on chromosome 7q34 ...
Appay, Romain +13 more
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Annals of Oncology, 2021 BACKGROUND Colorectal cancer (CRC) is still a leading cause of cancer-related deaths in the United States and worldwide, despite recent improvements in cancer management.
A. Grothey, M. Fakih, J. Tabernero
semanticscholar +1 more source
Ameloblastic Fibrosarcoma of the Jaw: Case Report, Genetic Profiling, and Literature Review
Case Reports in Oncology, 2023 Ameloblastic fibrosarcoma (AFS) is considered a malignant progression resulting from dysplastic changes in an ameloblastic fibroma (AF). Both tumors are extremely rare, with only a few cases reported in the scientific literature.
Duna Barakeh +2 more
doaj +1 more source
Molecular genetics of follicular cell thyroid carcinoma
Клиническая и экспериментальная тиреоидология, 2016 Thyroid cancer is the most frequent endocrine malignancy. In the most cases thyroid cancer arises from follicular cells. Diagnosis of the cancer is based on the cytological analysis of fine needle aspiration biopsy of thyroid nodes.
Valentina D. Yakushina +5 more
doaj +1 more source
Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer.
New England Journal of Medicine, 2019 BACKGROUND Patients with metastatic colorectal cancer with the BRAF V600E mutation have a poor prognosis, with a median overall survival of 4 to 6 months after failure of initial therapy.
S. Kopetz +34 more
semanticscholar +1 more source
BRAF mutation in colorectal cancer: An update [PDF]
Archive of Oncology, 2023 Colon cancer is a leading cause of cancer-related deaths worldwide. About 10% of all colon cancer patients are found to have a mutation in BRAF proto-oncogene that arise as a result of a substitution of amino acid valine with glutamate at position 600 ...
Colombo Alfredo +2 more
doaj
Phenotype-Genotype Correlation in Colorectal Cancer: A Real-Life Study
GE: Portuguese Journal of Gastroenterology, 2021 Background and Aims: Colorectal cancer (CRC) is a heterogeneous disease with distinctive genetic pathways, such as chromosomal instability, microsatellite instability and methylator pathway.
Catarina Frias-Gomes +14 more
doaj +1 more source
Next generation sequencing of exceptional responders with BRAF-mutant melanoma: implications for sensitivity and resistance. [PDF]
, 2015 BackgroundPatients with BRAF mutation-positive advanced melanoma respond well to matched therapy with BRAF or MEK inhibitors, but often quickly develop resistance.MethodsTumor tissue from ten patients with advanced BRAF mutation-positive melanoma who ...
Cronin, Maureen T +9 more
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Dabrafenib: A narrative drug review
Cancer Research, Statistics, and Treatment, 2020 Activating mutations in the BRAF gene lead to an unregulated downstream signaling of the MAPK/extracellular-signal-regulated kinase pathway. This pathway is implicated in a range of solid tumors, and BRAF inhibitors are an attractive option in the ...
Lakhan Kashyap +2 more
doaj +1 more source
MicroRNAs in melanoma development and resistance to target therapy [PDF]
, 2017 microRNAs constitute a complex class of pleiotropic post-transcriptional regulators of gene expression involved in the control of several physiologic and pathologic processes.
Ascierto, Paolo Antonio +7 more
core +1 more source