The frequency of mutations in advanced thyroid cancer in Japan: a single-center study
Endocrine JournalWe analyzed the outcomes of genetic testing to study the frequency of mutations in advanced thyroid cancer in Japan. Patients (n = 96) with unresectable or metastatic thyroid carcinoma were included for retrospective chart review.
Soji Toda +8 more
doaj +1 more source
Heterogeneity and clonal evolution of colorectal cancer
Успехи молекулярной онкологии, 2017 There are a lot of studies that dedicated to genetic differences between the primary tumor and metastases. This becomes relevant not only for molecular biologists for understanding carcinogenesis, but also becoming increasingly important for medical ...
M. Yu. Fedyanin +2 more
doaj +1 more source
Combination treatment with recombinant methioninase enables temozolomide to arrest a BRAF V600E melanoma in a patient-derived orthotopic xenograft (PDOX) mouse model. [PDF]
, 2017 An excessive requirement for methionine termed methionine dependence, appears to be a general metabolic defect in cancer. We have previously shown that cancer-cell growth can be selectively arrested by methionine deprivation such as with recombinant ...
Chmielowski, Bartosz +15 more
core +2 more sources
Melanoma BRAF Fusions—Letter [PDF]
Clinical Cancer Research, 2014 We read with interest the article by Hutchinson and colleagues ([1][1]) describing melanomas harboring BRAF fusions and their sensitivity to MEK inhibition. We also have reported recurrent BRAF fusions in melanocytic neoplasms, including melanomas, and would like to comment on some of ...
Thomas, Botton +2 more
openaire +2 more sources
Serrated lesions of the colon and rectum: Emergent epidemiological data and molecular pathways
Open Medicine, 2020 In 2010, serrated polyps (SP) of the colon have been included in the WHO classification of digestive tumors. Since then a large corpus of evidence focusing on these lesions are available in the literature.
Sacco Michele +13 more
doaj +1 more source
Melanoma BRAF Fusions—Response [PDF]
Clinical Cancer Research, 2014 We appreciate the comments from Dr. Botton and colleagues ([1][1]) regarding our article entitled “BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition” ([2][2]). In response to their letter, we make the following points: 1.
Katherine E, Hutchinson +5 more
openaire +2 more sources
Hyperplastic Polyposis Syndrome Identified with a BRAF Mutation
Gut and Liver, 2012 Background/AimsHydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) and peroxisome proliferator-activated receptor gamma (PPARγ) ligands can modulate cellular differentiation, proliferation, and apoptosis through various pathways.
doaj +1 more source
Serous ovarian carcinoma. Cytological and immunocytochemical and molecular genetic diagnostics
Опухоли женской репродуктивной системы, 2016 The results of diagnostics of 65 patients with serous ovarian carcinoma are given in the article. Analysis of the investigation has allowed to include 13 patients (20 %) in the group 1 (low grade) and 52 (80 %) in the group 2 (high grade).
O. G. Grigoruk +3 more
doaj +1 more source
Targeted Therapy in the Management of Modern Craniopharyngiomas
Frontiers in Bioscience-Landmark, 2022 Background: The proximity of craniopharyngiomas (CPs) to critical neurovascular structures can lead to a host of neurologic and endocrine complications that lead to difficulty with surgical management. In this review, we examine the molecular and genetic
Maikerly Reyes +7 more
doaj +1 more source
Prospective study of a molecular selection profile for RAS wild type colorectal cancer patients receiving irinotecan-cetuximab [PDF]
, 2015 Background: The aim of our study was to evaluate whether a panel of biomarkers, prospectively analysed might be able to predict patients' clinical outcome more accurately than RAS status alone.
Abouelkhair, KM +10 more
core +3 more sources