Results 31 to 40 of about 198,722 (342)
Melanoma: clinical-pathological and molecular analysis in patients of Ibague city, Colombia
Duazary, 2020 This study aimed to establish the clinicopathological characteristics of patients with melanoma and its association with BRAF gene mutations. The pathology reports and paraffin-embedded tumor samples from 47 women and 30 men with melanoma, with an ...
Carlos Puentes +5 more
doaj +1 more source
Acta Medica Bulgarica, 2021 Introduction: Thyroid carcinoma is the most common endocrine cancer. Some somatic mutations in genes (BRAF, NRAS and TERT) involved in key signaling pathways and genome stability have been recently identified to play an important role in its development.
Vidinov K. +8 more
doaj +1 more source
BRAFV600E mutation positive metastatic melanoma in a young woman treated with anti-BRAF/anti MEK combination: a case report [PDF]
, 2015 The recent Combi-v [1] and Combi-d [2,3], phase III randomized trials, showed, respectively, an OS benefit with Dabrafenib/Trametinib combination versus Vemurafenib and an improvement in PFS and ORR with the same combination versus Dabrafenib alone ...
CORTESI, Enrico +6 more
core +2 more sources
Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells. [PDF]
, 2014 BACKGROUND: The importance of the genetic background of cancer cells for the individual susceptibility to cancer treatments is increasingly apparent.
Arozarena, Imanol +5 more
core +2 more sources
Türk Patoloji Dergisi, 2023 Objective: Primary anorectal melanomas (AMs) are uncommon neoplasms with aggressive behavior. Molecular profile and clinicopathologic features of AMs are still not well established.
Orhun Cig TASKIN +6 more
doaj +1 more source
The Ewha Medical Journal, 2021 Over the past decade, substantial advances have been made in the individualization of therapeutic strategies for metastatic colorectal cancer (mCRC).
doaj +1 more source
Frequency and significance of Ras, Tert promoter, and Braf mutations in cytologically indeterminate thyroid nodules: A monocentric case series at a tertiary-level Endocrinology unit [PDF]
, 2017 PurposeThe management of thyroid nodules of indeterminate cytology is controversial. Our study aimed to establish the frequency and significance of H-,K-,N-RAS, TERT promoter, and BRAF gene mutations in thyroid nodes of indeterminate cytology and to ...
Barollo, Susi +13 more
core +2 more sources
Clinical Development of BRAF plus MEK Inhibitor Combinations.
Trends in Cancer, 2020 Genomic profiling shows that many solid tumors are characterized by specific driver aberrations, and this has expanded the therapeutic options for many patients. The mitogen-activated protein kinase (MAPK) pathway is a key cell signaling pathway involved
V. Subbiah, C. Baik, J. Kirkwood
semanticscholar +1 more source
Molecular testing approaches in thyroid cancer diagnosis
Journal of Biochemical and Clinical Genetics, 2020 Thyroid cancer (TC) is the most common endocrine malignancy worldwide, with an annual incidence of around 300,000 cases. In recent decades, the incidence of TC in many countries, including Saudi Arabia, has increased significantly.
Abdul-Mohsen Gaeth AlHejaily +1 more
doaj +1 more source
Cancer Biology & Medicine, 2022 Objective: PD-L1 and PD-L2 expression levels determine immune evasion and the therapeutic efficacy of immune checkpoint blockade. The factors that drive inducible PD-L1 expression have been extensively studied, but mechanisms that result in constitutive ...
Panpan Ma +12 more
doaj +1 more source