Results 31 to 40 of about 249,425 (238)

Unaltered low nerve growth factor and high brain-derived neurotrophic factor levels in plasma from patients with fibromyalgia after a 15-week progressive resistance exercise

Journal of Rehabilitation Medicine, 2019
Background: The pathophysiology of fibromyalgia includes central and peripheral factors. Neurotrophins, such as nerve growth factor and brain-derived neurotrophic factor, are involved in peripheral and central nervous system development of pain and ...
Anna Jablochkova, Emmanuel Bäckryd, Eva Kosek, Kaisa Mannerkorpi, Malin Ernberg, Björn Gerdle, Bijar Ghafouri   +6 more
doaj   +1 more source

Repair of peripheral nerve defects with chemically extracted acellular nerve allografts loaded with neurotrophic factors-transfected bone marrow mesenchymal stem cells

Neural Regeneration Research, 2015
Chemically extracted acellular nerve allografts loaded with brain-derived neurotrophic factor-transfected or ciliary neurotrophic factor-transfected bone marrow mesenchymal stem cells have been shown to repair sciatic nerve injury better than chemically ...
Yan-ru Zhang, Ka Ka, Ge-chen Zhang, Hui Zhang, Yan Shang, Guo-qiang Zhao, Wen-hua Huang   +6 more
doaj   +1 more source

Modulation of neurotrophic signaling pathways by polyphenols [PDF]

, 2015
Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza, Hosseini, Razieh, Moosavi, Fatemeh, Saso, Luciano   +3 more
core   +1 more source

Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities

Journal of Neural Transplantation and Plasticity, 2020
With the rise in the aging global population, stroke comorbidities have become a serious health threat and a tremendous economic burden on human society. Current therapeutic strategies mainly focus on protecting neurons from cytotoxic damage at the acute
Wei Liu, Xiaohui Wang, M. O'Connor, Guan Wang, Fang Han   +4 more
semanticscholar   +1 more source

Involvement of ras p2I in Neurotrophin-induced Response of Sensory, but Not Sympathetic Neurons [PDF]

, 1993
Little is known about the signal transduction mechanisms involved in the response to neurotrophins and other neurotrophic factors in neurons, beyond the activation of the tyrosine kinase activity of the neurotrophin receptors belonging to the trk family.
Barde, Y. A., Borasio, Gian Domenico, Heumann, R., Markus, A., Wittinghofer, A.   +4 more
core   +3 more sources

Leukemia Inhibitory Factor Augments Neurotrophin Expression and Corticospinal Axon Growth after Adult CNS Injury [PDF]

, 1999
The cytokine leukemia inhibitory factor (LIF) modulates glial and neuronal function in development and after peripheral nerve injury, but little is known regarding its role in the injured adult CNS.
Blesch, A., Cheng, J.-G., Grill, R. J., Patterson, P. H., Tuszynski, M. H., Uy, H. S.   +5 more
core   +1 more source

Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus

Journal of Neuroscience, 1995
Chronic stress produces structural changes and neuronal damage especially in the hippocampus. Because neurotrophic factors affect neuron survival, we questioned whether they might be relevant to the heightened vulnerability of hippocampal neurons ...
M. A. Smith, Shinya Makino, R. Kvetňanský, Robert M. Post, Psychiatry Branch   +4 more
semanticscholar   +1 more source

The glycoside oleandrin reduces glioma growth with direct and indirect effects on tumor cells [PDF]

, 2017
Oleandrin is a glycoside that inhibits the ubiquitous enzyme Na(+)/K(+)-ATPase. In addition to its known effects on cardiac muscle, recent in vitro and in vivo evidence highlighted its potential for anticancer properties. Here, we evaluated for the first
CHECE, Giuseppina, Cortese, Barbara, D'ALESSANDRO, GIUSEPPINA, DI ANGELANTONIO, SILVIA, ESPOSITO, Vincenzo, GAROFALO, STEFANO, GRIMALDI, ALFONSO, LIMATOLA, Cristina, MAINIERO, Fabrizio, MORRONE, Stefania, PORZIA, Alessandra, TRETTEL, Flavia   +11 more
core   +1 more source

The role of the TrkB-T1 receptor in the neurotrophin-4/5 antagonism of brain-derived neurotrophic factor on corticostriatal synaptic transmission

Neural Regeneration Research, 2020
This manuscript reviews the function and fundamental characteristics of the neurotrophins and their receptors to introduce the reader to the differential effects exhibited by the neurotrophins; brain-derived neurotrophic factor and neurotrophin 4/5 when ...
Elizabeth Hernandez-Echeagaray
doaj   +1 more source

Alginate-encapsulated brain-derived neurotrophic factor–overexpressing mesenchymal stem cells are a promising drug delivery system for protection of auditory neurons

Journal of Tissue Engineering, 2020
The cochlear implant outcome is possibly improved by brain-derived neurotrophic factor treatment protecting spiral ganglion neurons. Implantation of genetically modified mesenchymal stem cells may enable the required long-term brain-derived neurotrophic ...
Jana Schwieger, Anika Hamm, Michael M. Gepp, André Schulz, Andrea Hoffmann, Thomas Lenarz, Verena Scheper   +6 more
doaj   +1 more source