Results 71 to 80 of about 2,666,950 (303)

Studying the Brain–Gut Axis with Pharmacological Imaging [PDF]

Annals of the New York Academy of Sciences, 2008
Pharmacological imaging provides great potential both for evaluating the efficacy of new candidate compounds in the treatment of gastrointestinal symptom‐based disorders, and for furthering our understanding of the underlying pathophysiology of such disorders.
Kirsten, Tillisch, Zhuo, Wang, Lisa, Kilpatrick, Daniel P, Holschneider, Emeran A, Mayer   +4 more
openaire   +2 more sources

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Sex-dependent effects of a high fat diet on metabolic disorders, intestinal barrier function and gut microbiota in mouse

Scientific Reports
Obesity is often associated with sex-dependent metabolic complications, in which altered intestinal barrier function and gut microbiota contribute. We aimed to characterize in mice the sex-dependent effects of a high fat diet on these parameters.
Candice Lefebvre, Adam Tiffay, Charles-Edward Breemeersch, Virginie Dreux, Christine Bôle-Feysot, Charlène Guérin, Jonathan Breton, Elise Maximin, Magali Monnoye, Pierre Déchelotte, Véronique Douard, Alexis Goichon, Moïse Coëffier   +12 more
doaj   +1 more source

Immune modulation of the brain-gut-microbe axis [PDF]

Frontiers in Microbiology, 2014
1 Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland 2 Department of Industrial Biotechnology, Genetic Engineering and Biotechnology Research Institute, Sadat City University, Sadat City, Egypt 3 Department of Psychiatry, University College Cork, Cork, Ireland 4 Department of Anatomy and ...
El Aidy, Sahar, Dinan, Timothy G., Cryan, John F.   +2 more
openaire   +3 more sources

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

Brain-gut axis: From the conditioned reflex to the microbiota-gut-brain communication system

Интегративная физиология, 2020
Communication between the central nervous system (CNS) and the gastrointestinal tract is called the brain-gut axis. This communication network includes the CNS, hypothalamic-pituitary-adrenal axis, the autonomic nervous system (sympathetic and ...
Klara Gyires
doaj   +1 more source

The gut-brain axis in ischemic stroke: its relevance in pathology and as a therapeutic target

Neurological Research and Practice, 2022
The gut contains the largest reservoir of microorganisms of the human body, termed as the gut microbiota which emerges as a key pathophysiological factor in health and disease. The gut microbiota has been demonstrated to influence various brain functions
Corinne Benakis, Arthur Liesz
doaj   +1 more source

The Role of the Endocannabinoid System in the Brain–Gut Axis [PDF]

Gastroenterology, 2016
The actions of cannabis are mediated by receptors that are part of an endogenous cannabinoid system. The endocannabinoid system (ECS) consists of the naturally occurring ligands N-arachidonoylethanolamine (anandamide) and 2-arachidonoylglycerol (2-AG), their biosynthetic and degradative enzymes, and the cannabinoid (CB) receptors CB1 and CB2.
Keith A, Sharkey, John W, Wiley
openaire   +2 more sources

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Anxiety and depression and their impact on functional recovery and quality of life in Guillain-Barré syndrome: a prospective cohort study in Bangladesh

BMJ Open
Objectives Guillain-Barré syndrome (GBS) is an autoimmune polyneuropathy manifested by progressive limb weakness. Anxiety and depression are significant yet under-recognised complications of GBS, particularly in low- and middle-income countries (LMICs ...
Zhahirul Islam, M Tasdik Hasan, Quazi Deen Mohammad, Gulshan Ara, Shahadat Hossain, Nowshin Papri, Mantaka Rahman, Tamal Saha, Ashiqa Tabassum, M M Jalal Uddin, Md Shahanur Hossain, Liza Akter, Khalid M Khan   +12 more
doaj   +1 more source