Results 101 to 110 of about 188,500 (303)

Friend, Not Foe: Lowered Tissue Reactivity to Long‐Term Polyimide Implants

Advanced Science, EarlyView.
The choice of optimal neural probe designs remains a major challenge in the field of neurotechnology. This study investigated the biocompatibility of several probe variations, including material, thickness, width, and implantation strategy. It highlights the clear advantage of soft polyimide probes over stiff silicon probes for better device ...
Corinne Orlemann, Laura M. De Santis, Paul Neering, Christian Boehler, Kirti Sharma, Arno Aarts, Tobias Holzhammer, Rik J. J. van Daal, Patrick Ruther, Maria Asplund, Roxana N. Kooijmans, Pieter R. Roelfsema   +11 more
wiley   +1 more source

Simvastatin in traumatic brain injury: Effect on brain edema mechanisms [PDF]

, 2011
International audienceObjectives: Traumatic brain injury causes deleterious brain edema, leading to high mortality and morbidity. Brain edema exacerbates neurologic deficits and may be attributable to the breakdown of endothelial cell junction protein ...
Mathieu Soustrat, Michel Plotkine, Marchand-Leroux, Catherine, Xiao Ru Chen, Isabelle Margaill, El Shafey, Nelly, Besson, Valérie, Margaill, Isabelle, Tiphaine Béziaud, Beray-Berthat, Virginie, Magalie Fréchou, Catherine Marchand-Leroux, Bruno Palmier, Valérie C. Besson, Nelly El Shafey, Fréchou, Magalie, Plotkine, Michel, Ru Chen, Xiao, Soustrat, Mathieu, Virginie Beray-Berthat, Teng, Fei, Béziaud, Tiphaine, Palmier, Bruno, Fei Teng   +23 more
core   +1 more source

A Humanized Anti‐gD Broadly Neutralizing Antibody Confers Complete Post‐Exposure Protection against Pseudorabies Virus

Advanced Science, EarlyView.
Pseudorabies virus (PRV), an emerging zoonotic α‐herpesvirus, causes life‐threatening human encephalitis. We identified a broad‐spectrum neutralizing antibody 6F7 targeting PRV gD. It blocks gD‐Nectin‐1 binding and membrane fusion, inhibiting replication across all PRV variants, representing a promising candidate for anti‐PRV therapy.
Yue Sun, Jianbo Liu, Shi‐Jia Xu, Meng‐Xin Wang, Hongliang Zhang, Yanhe Zhang, Zhi‐Jun Tian, Jin‐Mei Peng, Xin Yin, Tong‐Qing An, Xue‐Hui Cai, Yan‐Dong Tang   +11 more
wiley   +1 more source

Early oxygen therapy does not protect the brain from vasogenic edema following acute ischemic stroke in adult male rats

Scientific Reports, 2017
Brain edema aggravates primary brain injury and increases its mortality rate after ischemic stroke. It is believed that normobaric oxygen therapy (NBO) may produce neuroprotective effects against ischemic stroke; however, reports have been controversial,
Elmira Pasban, Hamdollah Panahpour, Akbar Vahdati   +2 more
doaj   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Neurological consequences of traumatic brain injuries in sports. [PDF]

, 2015
Traumatic brain injury (TBI) is common in boxing and other contact sports. The long term irreversible and progressive aftermath of TBI in boxers depicted as punch drunk syndrome was described almost a century ago and is now widely referred as chronic ...
Zetterberg, H, Ling, Helen, Zetterberg, Henrik,, Ling, H, Hardy, J, Hardy, John   +5 more
core   +1 more source

Effects of steroids on vasogenic edema due to brain tumors, a narrative review

Interdisciplinary Neurosurgery
Background and objectives: Tumor-associated edema is a serious condition that can lead to severe complications. Corticosteroids in the treatment of edema can be administered postoperatively or preoperatively.
Marzieh Shahrabi, Azin Abdollahi, Mohammad Niakan Lahiji, Tahereh Sorbi, Mohammad Solduzian   +4 more
doaj   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Depolarization increases cellular light transmission [PDF]

, 2008
Application of optical methods to human brain tissue in vivo, e.g., measuring oxyhemoglobin and deoxyhemoglobin concentration changes with near-infrared spectroscopy (NIRS), requires the a priori assumption that background optical properties remain ...
Takashi Osada, Miyuki Unekawa, Jemal Tatarishvili, Minoru Tomita, Haruki Toriumi, Norihiro Suzuki, Yutaka Tomita   +6 more
core   +1 more source

Racking the brain: detection of cerebral edema on postmortem computed tomography compared with forensic autopsy [PDF]

, 2015
PURPOSE The purpose of this study was to compare postmortem computed tomography with forensic autopsy regarding their diagnostic reliability of differentiating between pre-existing cerebral edema and physiological postmortem brain swelling ...
Schweitzer, Wolf, Ross, Steffen G, Thali, Michael J, Gascho, Dominic, Berger, Nicole, Ruder, Thomas, Ampanozi, Garyfalia; https://orcid.org/, Ruder, Thomas D, Ampanozi, Garyfalia, Flach, Patricia M   +9 more
core   +1 more source