Results 101 to 110 of about 6,284,362 (305)

Eicosapentaenoic acid metabolism in brain microvessel endothelium: effect on prostaglandin formation.

Journal of Lipid Research, 1989
Mouse brain microvessel endothelial cells convert eicosapentaenoic acid (EPA) to prostaglandin (PG) E3, PGI3, and several hydroxy fatty acid derivatives.
N R Yerram, S A Moore, A A Spector
doaj   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2

Journal of Neuroinflammation, 2018
Background Mast cells (MCs), the ‘first responders’ in brain injury, are able to disrupt the blood–brain barrier (BBB), but the underlying mechanism is not well understood. Tryptase is the most abundant MC secretory product. Protease-activated receptor 2
Qin Zhou, Yi-wei Wang, Peng-fei Ni, Yi-nan Chen, Hong-quan Dong, Yan-ning Qian   +5 more
doaj   +1 more source

Guanosine‐Quadruplex Hydrogels as Dynamic, Mechanically Tunable and Ion Conductive 3D Scaffolds for Cell Culture Applications

Advanced Functional Materials, EarlyView.
Versatile guanosine‐quadruplex (GQ) hydrogels are developed as dynamic biomatrices for cell culture. These scaffolds are fabricated under mild aqueous conditions, present improved stability, tunable mechanical properties within physiological ranges; fibrillar, porous microstructure, ion conductivity, and cytocompatibility.
Neha Thakur, Minye Jin, Pavel Milkin, Deepa Negi, Carla Cofiño Fabres, Hubert Gojzewski, Leonid Ionov, Alla Synytska, Andries van der Meer, Robert Passier, Julieta I. Paez   +10 more
wiley   +1 more source

Do nanoparticles used in laser tissue soldering interfere with endothelial cells and the blood-brain barrier? [PDF]

, 2020
Introduction: Over the past few decades, nanotechnology has been gaining importance, further broadening the scope of application for a wide range of nanomaterials, involving areas from all parts of life.
Bittner, Aniela
core  

Polystyrene nanoplastics promote the blood-brain barrier dysfunction through autophagy pathway and excessive erythrophagocytosis

Ecotoxicology and Environmental Safety
There is increasing concern regarding the risks posed by plastics to human health. Nano-sized plastics enter the body through various exposure routes. Although nano-sized particles circulate through the bloodstream and access the blood-brain barrier (BBB)
Eun-Hye Kim, Seung Mi Baek, Han Jin Park, Yiying Bian, Han Young Chung, Ok-Nam Bae   +5 more
doaj   +1 more source

Effect of heat stress on blood-brain barrier integrity in iPS cell-derived microvascular endothelial cell models.

PLoS ONE, 2019
The incidence of heatstroke has been increasing. Heatstroke has been shown to affect physiological barrier functions. However, there are few studies of the effect of heat stress on the blood-brain barrier (BBB) function.
Tomoko Yamaguchi, Kentaro Shimizu, Yasuhiro Kokubu, Misae Nishijima, Shuko Takeda, Hiroshi Ogura, Kenji Kawabata   +6 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Characterization of lactoferrin receptor in brain endothelial capillary cells and mouse brain

Journal of Biomedical Science, 2006
We present, herein, the evidence for lactoferrin (Lf) binding sites in brain endothelial capillary cells (BCECs) and mouse brain. The results from confocal microscopy showed the presence of Lf receptors on the surface of BCECs and the receptor-mediated endocytosis for Lf to enter the cells.
Rong-qin, Huang, Wei-lun, Ke, Ying-hua, Qu, Jian-hua, Zhu, Yuan-ying, Pei, Chen, Jiang   +5 more
openaire   +2 more sources

Blood–Brain Barrier Regulation: Evolving From Classic Strategies to Electrochemical Ion and Reactive Oxygen Species Control

Advanced Healthcare Materials, EarlyView.
Conventional therapies suffer from poor blood–brain barrier (BBB) penetration and disordered ion/reactive oxygen species (ROS) homeostasis, hindering precise neurological treatment. Electrochemical strategies achieve accurate spatiotemporal regulation of neural homeostasis.
Xiaokang Hu, Caiyu Liu, Meijun Pang, Zhiyuan Shi, Dong Ming, Xiuyun Liu   +5 more
wiley   +1 more source