Brain energy metabolism is optimized to minimize the cost of enzyme synthesis and transport. [PDF]
Proc Natl Acad Sci U S A, 2022 Energy metabolism of the brain is poorly understood partly due to the complex morphology of neurons. Here we used metabolic models that estimate costs of enzyme usage per pathway, enzyme utilization over time, and enzyme transport to evaluate a paradigm ...
Gustafsson J +3 more
europepmc +2 more sources
Brain Energy Metabolism in Ischemic Stroke: Effects of Smoking and Diabetes. [PDF]
Int J Mol Sci, 2022 Proper regulation of energy metabolism in the brain is crucial for maintaining brain activity in physiological and different pathophysiological conditions.
Sifat AE +4 more
europepmc +2 more sources
Glia in brain energy metabolism: A perspective. [PDF]
Glia, 2018 Barros LF, Brown A, Swanson RA.
europepmc +4 more sources
GSK3β Regulates Brain Energy Metabolism. [PDF]
Cell Rep, 2018 GSK3β is a serine threonine kinase implicated in the progression of Alzheimer's disease. Although the role of GSK3β in growth and pathology has been extensively studied, little is known about the metabolic consequences of GSK3β manipulation, particularly in the brain.
Martin SA +8 more
europepmc +5 more sources
Brain Regulation of Energy Metabolism [PDF]
Endocrinology and Metabolism, 2016 In healthy individuals, energy intake is in balance with energy expenditure, which helps to maintain a normal body weight. The brain's inability to control energy homeostasis underlies the pathology of hyperphagia and obesity.
Eun Roh, Min-Seon Kim
doaj +3 more sources
Current technical approaches to brain energy metabolism. [PDF]
Glia, 2018 AbstractNeuroscience is a technology‐driven discipline and brain energy metabolism is no exception. Once satisfied with mapping metabolic pathways at organ level, we are now looking to learn what it is exactly that metabolic enzymes and transporters do and when, where do they reside, how are they regulated, and how do they relate to the specific ...
Barros LF +11 more
europepmc +10 more sources
Roles of β-Endorphin in Stress, Behavior, Neuroinflammation, and Brain Energy Metabolism. [PDF]
Int J Mol Sci, 2020 β-Endorphins are peptides that exert a wide variety of effects throughout the body. Produced through the cleavage pro-opiomelanocortin (POMC), β-endorphins are the primarily agonist of mu opioid receptors, which can be found throughout the body, brain ...
Pilozzi A, Carro C, Huang X.
europepmc +2 more sources
HIV-Tat and Cocaine Impact Brain Energy Metabolism: Redox Modification and Mitochondrial Biogenesis Influence NRF Transcription-Mediated Neurodegeneration. [PDF]
Mol Neurobiol, 2021 HIV infection and drugs of abuse induce oxidative stress and redox imbalance, which cause neurodegeneration. The mechanisms by which HIV infection and cocaine consumption affect astrocyte energy metabolism, and how this leads to neurodegenerative ...
Sivalingam K +3 more
europepmc +2 more sources
Pathology and Treatments of Alzheimer’s Disease Based on Considering Changes in Brain Energy Metabolism Due to Type 2 Diabetes [PDF]
MoleculesAlzheimer’s disease (AD) is a progressive neurodegenerative disorder with cognitive dysfunction, memory decline, and behavioral disturbance, and it is pathologically characterized by the accumulation of amyloid plaques and neurofibrillary tangles in the ...
Hidekatsu Yanai +3 more
doaj +2 more sources
Impaired energy metabolism and altered brain histoarchitecture characterized by inhibition of glycolysis and mitochondrial electron transport-linked enzymes in rats exposed to diisononyl phthalate [PDF]
HeliyonThe brain is an energy demanding organ, constituting about 20 % of the body's resting metabolic rate. An efficient energy metabolism is critical to neuronal functions.
Samuel Abiodun Kehinde +8 more
doaj +2 more sources