Results 31 to 40 of about 2,320 (212)

Energy, Entropy and Quantum Tunneling of Protons and Electrons in Brain Mitochondria: Relation to Mitochondrial Impairment in Aging-Related Human Brain Diseases and Therapeutic Measures

Biomedicines, 2021
Adult human brains consume a disproportionate amount of energy substrates (2–3% of body weight; 20–25% of total glucose and oxygen). Adenosine triphosphate (ATP) is a universal energy currency in brains and is produced by oxidative phosphorylation ...
James P. Bennett, Isaac G. Onyango
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Elucidating reaction dynamics in a model of human brain energy metabolism.

PLoS Computational Biology
Energy metabolism is essential to brain function and Bioinformatics, but its study is experimentally challenging. Similarly, biologically accurate computational models are too complex for simple investigations.
Dimitrios G Patsatzis, Efstathios-Al Tingas, Subram Mani Sarathy, Dimitris A Goussis, Renaud Blaise Jolivet   +4 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Neuron-astroglial interactions in dysregulation of energy metabolism in perinatal ischemic brain damage

Анналы клинической и экспериментальной неврологии, 2017
Presented is a review of the literature on the problem of hypoxic-ischemic perinatal brain damage in the context of alterations of astroglial regulation of neuronal energy metabolism and mechanisms of excitotoxicity.
A. B. Salmina, S. O. Okuneva, T. E. Taranushenko, A. A. Fursov, S. V. Prokopenko, S. V. Mikhutkina, N. A. Malinovskaya, G. A. Tagaeva   +7 more
doaj   +1 more source

Brain Mass (Energy) Resistant to Hyperglycaemic Oversupply: A Systematic Review

Frontiers in Neuroscience, 2021
Cerebral energy supply is determined by the energy content of the blood. Accordingly, the brain is undersupplied during hypoglycaemia. Whether or not there is an additional cerebral energy demand that depends upon the energy content of the brain is ...
Marie Sprengell, Britta Kubera, Achim Peters   +2 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Brain-acting hepatokines: its impact on energy balance and metabolism

Frontiers in Neuroscience
The liver is recognized for its central role in energy metabolism, yet emerging evidence highlights its function as an endocrine organ, secreting a variety of proteins—hepatokines—that influence distant tissues.
Lucía Giovanini, Nahuel Wanionok, Mario Perello, Mario Perello, Maria Paula Cornejo   +4 more
doaj   +1 more source

Estrogen suppresses the impact of glucose deprivation on astrocytic calcium levels and signaling independently of the nuclear estrogen receptor

Neurobiology of Disease, 2005
Glucose deprivation of astrocytes results in an elevation of cytosolic calcium concentration ([Ca2+]i) [Kahlert, S., Reiser, G., 2000. Requirement of glycolytic and mitochondrial energy supply for loading of Ca2+ stores and InsP3-mediated Ca2+ signaling ...
Susanne Arnold
doaj   +1 more source

Energy Metabolism Decline in the Aging Brain—Pathogenesis of Neurodegenerative Disorders

Metabolites, 2020
There is a growing body of evidencethat indicates that the aging of the brain results from the decline of energy metabolism. In particular, the neuronal metabolism of glucose declines steadily, resulting in a growing deficit of adenosine triphosphate ...
Janusz Wiesław Błaszczyk
doaj   +1 more source