Results 51 to 60 of about 8,068,126 (191)

Intracellular ATP influences synaptic plasticity in area CA1 of rat hippocampus via metabolism to adenosine and activity-dependent activation of adenosine A1 receptors [PDF]

, 2011
The extent to which brain slices reflect the energetic status of the in vivo brain has been a subject of debate. We addressed this issue to investigate the recovery of energetic parameters and adenine nucleotides in rat hippocampal slices and the ...
D. Grahame Hardie, Hardie, D. G. (D. Grahame), Naomi Pentland, Simon Hawley, Frenguelli, Bruno, Doney, Alexander S., Pentland, Naomi, Frenguelli, Bruno G., Stephanie zur Nedden, Hawley, Simon, Alexander S. Doney, Bruno G. Frenguelli, Hardie, D. Grahame, Doney, Alexander S.; id_orcid, Zur Nedden, Stephanie   +14 more
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Chemotherapy effects on brain glucose metabolism at rest [PDF]

, 2011
Background: A growing number of studies reports that chemotherapy may impair brain functions inducing cognitive changes which can persist in a subset of cancer survivors.
Riccardo Torta, Elisabetta Geda, Bruno Baudino, Katiuscia Sacco, Gianni Bisi, Federico D'Agata, Giancarlo Castellano, Laura Orsi, Simona Cauda, Rita Ardito, Lorys Castelli, Matteo Manfredi, Paola Caroppo, Antonella Parente, Franco Cauda   +14 more
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Deregulation of oxidative phosphorylation system and energy homeostasis in Alzheimer's disease [PDF]

, 2009
Alzheimer’s disease (AD) is the most frequent form of dementia among the elderly affecting dozens of million people worldwide. Post-mortem, the disease is characterized by two main neuropathological hallmarks: extracellular amyloid plaques and ...
Rhein, Virginie
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Estrogen suppresses the impact of glucose deprivation on astrocytic calcium levels and signaling independently of the nuclear estrogen receptor

Neurobiology of Disease, 2005
Glucose deprivation of astrocytes results in an elevation of cytosolic calcium concentration ([Ca2+]i) [Kahlert, S., Reiser, G., 2000. Requirement of glycolytic and mitochondrial energy supply for loading of Ca2+ stores and InsP3-mediated Ca2+ signaling ...
Susanne Arnold
doaj   +1 more source

Relationship of Parieto-Occipital Brain Energy Phosphate Metabolism and Cognition Using 31P MRS at 7-Tesla in Amnestic Mild Cognitive Impairment

Frontiers in Aging Neuroscience, 2020
BackgroundThe human brain has high energy requirements that continuously support healthy neuronal activity and cognition. A disruption in brain energy metabolism (BEM) may contribute to early neuropathological changes such as accumulation of β-amyloid ...
Namrata Das, Jimin Ren, Jeffrey S. Spence, Audette Rackley, Sandra B. Chapman   +4 more
doaj   +1 more source

Neuron-astroglial interactions in dysregulation of energy metabolism in perinatal ischemic brain damage

Анналы клинической и экспериментальной неврологии, 2017
Presented is a review of the literature on the problem of hypoxic-ischemic perinatal brain damage in the context of alterations of astroglial regulation of neuronal energy metabolism and mechanisms of excitotoxicity.
A. B. Salmina, S. O. Okuneva, T. E. Taranushenko, A. A. Fursov, S. V. Prokopenko, S. V. Mikhutkina, N. A. Malinovskaya, G. A. Tagaeva   +7 more
doaj   +1 more source

The environment within: how gut microbiota may influence metabolism and body composition [PDF]

, 2010
Obesity, diabetes and consequently atherosclerotic vascular disease have become major health and public health issues worldwide. The increasing and staggering prevalence of obesity might not only be explained by nutritional habits or the reduction of ...
Vos, W.M., de, A. Vrieze, Hoekstra, J. B. L., E. G. Zoetendal, Zoetendal, E.G., F. Holleman, Vrieze, A., W. M. de Vos, J. B. L. Hoekstra, M. Nieuwdorp, Holleman, F., Zoetendal, E. G., Hoekstra, J.B., de Vos, W. M., de Vos, W.M., Nieuwdorp, M.   +15 more
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The mechanisms in glucose metabolism of aging hippocampus

Ibrain
With the intensification of the aging society, the incidence of various neurodegenerative diseases is on the rise. The hippocampus is susceptible to age‐related neuronal decline and is the earliest and crucial region affected in the transition from ...
Rui He, Fuxing Zhao, Zhiyu Yang, Tingting Wang, Yaohui Zhang, Jinglan Quan, Gaohong Zhu   +6 more
doaj   +1 more source

Cyanidin 3-O-β-galactoside from black chokeberry ameliorates brain glucose hypometabolism and cognitive impairment in mice through gut microbiota-derived short-chain fatty acids and amino acids

Food Science and Human Wellness
Neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, are associated with cognitive impairment and impaired brain glucose metabolism, posing significant challenges for the public health. We previously demonstrated that cyanidin
Xiaoyu Liu, Zhuoyan Fan, Wenjing Jiang, Wentao Gao, Xinquan Yang, Jingming Li   +5 more
doaj   +1 more source

Human metabolic adaptations and prolonged expensive neurodevelopment: A review [PDF]

, 2008
1. After weaning, human hunter-gatherer juveniles receive substantial (≈3.5-7 MJ day^-1^), extended (≈15 years) and reliable (kin and nonkin food pooling) energy provision. 2. The childhood (pediatric) and the adult human ...
John R. Skoyles
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