Results 61 to 70 of about 241,163 (293)

Estrogen suppresses the impact of glucose deprivation on astrocytic calcium levels and signaling independently of the nuclear estrogen receptor

Neurobiology of Disease, 2005
Glucose deprivation of astrocytes results in an elevation of cytosolic calcium concentration ([Ca2+]i) [Kahlert, S., Reiser, G., 2000. Requirement of glycolytic and mitochondrial energy supply for loading of Ca2+ stores and InsP3-mediated Ca2+ signaling ...
Susanne Arnold
doaj   +1 more source

Cerebrospinal fluid ATP metabolites in multiple sclerosis

, 2010
Increased axonal energy demand and mitochondrial failure have been suggested as possible causes for axonal degeneration and disability in multiple sclerosis.Our objective was to test whether ATP depletion precedes clinical, imaging and biomarker evidence
Uitdehaag, BMJ, Di Pietro, V., Barkhof, F., Killestein, J, Belli, A.; id_orcid, Killestein, J., Uitdehaag, B.M.J., Eikelenboom, M.J., University of Catania, Tavazzi, B, Petzold, A.F.S., Petzold, A., Petzold, A, Belli, A., Eikelenboom, MJ, Lazzarino, G., Lazzarino, G, Di Pietro, V, Polman, CH, Amorini, A.M., Barkhof, F, Tavazzi, B., Polman, C.H., Belli, A, Di Pietro, V.; id_orcid, Amorini, AM, Pietro, V. Di   +26 more
core   +1 more source

Energy Metabolism in the Inner Retina in Health and Glaucoma

, 2021
Glaucoma, the leading cause of irreversible blindness, is a heterogeneous group of diseases characterized by progressive loss of retinal ganglion cells (RGCs) and their axons and leads to visual loss and blindness.
Verena Prokosch, Hanhan Liu
core   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Cyanidin 3-O-β-galactoside from black chokeberry ameliorates brain glucose hypometabolism and cognitive impairment in mice through gut microbiota-derived short-chain fatty acids and amino acids

Food Science and Human Wellness
Neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, are associated with cognitive impairment and impaired brain glucose metabolism, posing significant challenges for the public health. We previously demonstrated that cyanidin
Xiaoyu Liu, Zhuoyan Fan, Wenjing Jiang, Wentao Gao, Xinquan Yang, Jingming Li   +5 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

The mechanisms in glucose metabolism of aging hippocampus

Ibrain
With the intensification of the aging society, the incidence of various neurodegenerative diseases is on the rise. The hippocampus is susceptible to age‐related neuronal decline and is the earliest and crucial region affected in the transition from ...
Rui He, Fuxing Zhao, Zhiyu Yang, Tingting Wang, Yaohui Zhang, Jinglan Quan, Gaohong Zhu   +6 more
doaj   +1 more source

Relationship of Parieto-Occipital Brain Energy Phosphate Metabolism and Cognition Using 31P MRS at 7-Tesla in Amnestic Mild Cognitive Impairment

Frontiers in Aging Neuroscience, 2020
BackgroundThe human brain has high energy requirements that continuously support healthy neuronal activity and cognition. A disruption in brain energy metabolism (BEM) may contribute to early neuropathological changes such as accumulation of β-amyloid ...
Namrata Das, Jimin Ren, Jeffrey S. Spence, Audette Rackley, Sandra B. Chapman   +4 more
doaj   +1 more source

Brain energy metabolism and its pathologies [PDF]

, 2016
The brain belongs amongst metabolically most active organs and disturbances of brain energy metabolism are commonly cited as a critical factor predisposing to neurodegeneration.
Nová, Jana
core  

Evidence of the Role of Omega-3 Polyunsaturated Fatty Acids in Brain Glucose Metabolism

, 2020
In mammals, brain function, particularly neuronal activity, has high energy needs. When glucose is supplemented by alternative oxidative substrates under different physiological conditions, these fuels do not fully replace the functions fulfilled by ...
Fabien Pifferi, Stephen C. Cunnane, Philippe Guesnet   +2 more
core   +1 more source