Effect of temperature and glia in brain size enlargement and origin of allometric body-brain size scaling in vertebrates [PDF]
, 2014 Background: Brain signaling requires energy. The cost of maintaining and supporting energetically demanding neurons is the key constraint on brain size.
Feng, Jianfeng +7 more
core +1 more source
Neural regulation of energy and bone homeostasis by the synaptic adhesion molecule Calsyntenin-3
Experimental and Molecular Medicine, 2020 Bone metabolism: Regulation by brain protein A protein that is highly expressed in brain cells plays a vital role in maintaining balanced energy expenditure and bone health.
Sung-Jin Kim +11 more
doaj +1 more source
BBA Advances, 2023 The brain is an organ that consumes a lot of energy. In the brain, energy is required for synaptic transmission, numerous biosynthetic processes and axonal transport in neurons, and for many supportive functions of glial cells.
Maria M. Bayliak +2 more
doaj +1 more source
A model of brain circulation and metabolism: NIRS signal changes during physiological challenges [PDF]
, 2008 We construct a model of brain circulation and energy metabolism. The model is designed to explain experimental data and predict the response of the circulation and metabolism to a variety of stimuli, in particular, changes in arterial blood pressure, CO2
Mallet, Alfred +18 more
core +1 more source
Association between cognitive performance and cortical glucose metabolism in patients with mild Alzheimer's disease [PDF]
, 2005 Background: Neuronal and synaptic function in Alzheimer's disease (AD) is measured in vivo by glucose metabolism using positron emission tomography (PET). Objective: We hypothesized that neuronal activation as measured by PET is a more sensitive index of
Teipel, S. J. +11 more
core +1 more source
Cell Reports, 2023 Summary: Neutrophil aggregation and clearance are important factors affecting neuroinflammatory injury during acute ischemic stroke. Emerging evidence suggests that energy metabolism is essential for microglial functions, especially microglial ...
Lei Li +9 more
doaj +1 more source
Multivitamins and minerals modulate whole-body energy metabolism and cerebral blood-flow during cognitive task performance: a double-blind, randomised, placebo-controlled trial [PDF]
, 2016 Background: The brain is by far the most metabolically active organ in the body, with overall energy expenditure and local blood-supply closely related to neural activity.
Jackson, Philippa A. +41 more
core +1 more source
Impairments in Oxidative Glucose Metabolism in Epilepsy and Metabolic Treatments Thereof
Frontiers in Cellular Neuroscience, 2018 There is mounting evidence that oxidative glucose metabolism is impaired in epilepsy and recent work has further characterized the metabolic mechanisms involved.
Tanya McDonald +3 more
doaj +1 more source
Creatine protects against excitoxicity in an in vitro model of neurodegeneration. [PDF]
, 2012 Creatine has been shown to be neuroprotective in aging, neurodegenerative conditions and brain injury. As a common molecular background, oxidative stress and disturbed cellular energy homeostasis are key aspects in these conditions. Moreover, in a recent
Geiger Johanna +17 more
core +1 more source
Scientific Reports, 2022 Communication between gut microbiota and the brain is an enigma. Alterations in the gut microbial community affects enteric metabolite levels, such as short chain fatty acids (SCFAs). SCFAs have been proposed as a possible mechanism through which the gut
Tiffany A. Fillier +8 more
doaj +1 more source