Results 91 to 100 of about 26,410 (296)
Brain organoids and insights on human evolution. [PDF]
, 2019 Human brain organoids, generated from pluripotent stem cells, have emerged as a promising technique for modeling early stages of human neurodevelopment in controlled laboratory conditions.
Muotri, Alysson R
core
, 2015 Collective cell responses to exogenous cues depend on cell-cell interactions. In principle, these can result in enhanced sensitivity to weak and noisy stimuli.
Amar, Patrick +11 more
core +3 more sources
Spontaneous Glioblastoma Spheroid Infiltration of Early-Stage Cerebral Organoids Models Brain Tumor Invasion. [PDF]
, 2018 Organoid methodology provides a platform for the ex vivo investigation of the cellular and molecular mechanisms underlying brain development and disease.
da Silva, B +4 more
core +1 more source
Poking Pluripotency: Nanoinjection Into Human iPSCs
Advanced Materials, EarlyView.Nanoinjection into hiPSCs: silicon nanotubes effectively transfect human induced pluripotent stem cells (hiPSCs) with mRNA, enabled by a delayed extracellular matrix application and enhanced surface functionalization. Nanoinjection is demonstrated with several reporter mRNA, including co‐transfection of mCherry and GFP.
Jann Harberts +5 more
wiley +1 more source
Exploring the prospects, advancements, and challenges of in vitro modeling of the heart-brain axis
Frontiers in Cellular NeuroscienceResearch on bidirectional communication between the heart and brain has often relied on studies involving nonhuman animals. Dependance on animal models offer limited applicability to humans and a lack of high-throughput screening.
Senegal Alfred Mabry, Narciso Pavon
doaj +1 more source
Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes [PDF]
, 2017 © 2017 The Authors Human astrocytes network with neurons in dynamic ways that are still poorly defined. Our ability to model this relationship is hampered by the lack of relevant and convenient tools to recapitulate this complex interaction.
Barlas, S +13 more
core +2 more sources
Advanced Materials Technologies, EarlyView.A novel sample holder compatible with the Zeiss Lightsheet 7 microscope improves imaging of spheroids embedded in collagen matrices. By enabling dual‐sided illumination, it enhances image quality and quantitative analysis of migrating cells. This method advances 3D light sheet microscopy for studying tumor invasion and therapeutic responses.
Masoumeh Mohamadian Namaqi +5 more
wiley +1 more source
Nature CommunicationsTo comprehend the volumetric neural connectivity of a brain organoid, it is crucial to monitor the spatiotemporal electrophysiological signals within the organoid, known as intra-organoid signals.
Enji Kim +12 more
doaj +1 more source
Single-Cell RNA Sequencing of hESC-Derived 3D Retinal Organoids Reveals Novel Genes Regulating RPC Commitment in Early Human Retinogenesis. [PDF]
, 2019 The development of the mammalian retina is a complicated process involving the generation of distinct types of neurons from retinal progenitor cells (RPCs) in a spatiotemporal-specific manner.
An, Qin +9 more
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Development of functional ectopic compound eyes in scarabaeid beetles by knockdown of orthodenticle [PDF]
, 2017 Complex traits like limbs, brains, or eyes form through coordinated integration of diverse cell fates across developmental space and time, yet understanding how complexity and integration emerge from uniform, undifferentiated precursor tissues remains ...
Busey, Hannah A. +3 more
core +1 more source