Results 181 to 190 of about 26,410 (296)

Modest neurodevelopment impacts of APOE4 in a human brain organoid model of low-grade SARS-CoV-2 infection. [PDF]

Dev Neurosci
Muniz-Perez A, Meyer-Acosta KK, Boyana S, Ponnala V, McMahon CL, Aruk A, Elizalde A, Hsieh J.   +7 more
europepmc   +1 more source

Inroads into epilepsy through high‐frequency oscillations: Achievements and benchmark areas for improvement

Epilepsia, EarlyView.
Abstract High‐frequency oscillations (HFOs) were discovered more than 20 years ago, and since then they have been studied intensively in the context of epilepsy. HFOs encompass a broad spectrum of oscillations, typically ranging from 80 Hz to several kHz, that include both normal and pathological oscillations, documented in people with epilepsy and ...
Christos Panagiotis Lisgaras, Birgit Frauscher, Jean Gotman, Julia Jacobs, Philippe Kahane, Richard J. Staba, Maeike Zijlmans   +6 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

RNA-binding activity of PHGDH drives amyloid-beta production in a human brain organoid model of sporadic Alzheimer's disease. [PDF]

Proc Natl Acad Sci U S A
Chen J, Xu M, Liu Y, Hadi F, Xue S, Chien S, Zhong S.   +6 more
europepmc   +1 more source

Micro Pattern‐Based 3D Cell Culture Platform: An Overview of Technologies and Applications

Exploration, EarlyView.
Micro patterns are characterized as a coating of specific adhesion matrices on substrates to support cell growth. An overview of micropattern technology to regulate single cell morphology and fates, further focusing on the micro pattern‐based 3D cell culture platform used in the non‐tumor and tumor researches.
Xinglong Zhu, Yi Li, Hulin Long, Yijia Wu, Ningwei Sun, Shun Li, Yiyao Liu, Huiqi Xie, Ji Bao   +8 more
wiley   +1 more source

Morphodynamics of human early brain organoid development. [PDF]

Nature
Jain A, Gut G, Sanchis-Calleja F, Tschannen R, He Z, Luginbühl N, Zenk F, Chrisnandy A, Streib S, Harmel C, Okamoto R, Santel M, Seimiya M, Holtackers R, Rohland JK, Jansen SMJ, Lutolf MP, Camp JG, Treutlein B.   +18 more
europepmc   +1 more source

The Ethics of Human Brain Organoid Transplantation in Animals. [PDF]

Neuroethics, 2023
Kataoka M, Gyngell C, Savulescu J, Sawai T.   +3 more
europepmc   +1 more source

When Rare Is Not Small: Amyotrophic Lateral Sclerosis Initiatives and Therapy

Exploration, EarlyView.
In the precision‐medicine era, rare diseases must not be sidelined in translational infrastructure. The Mr. Cai Lei—led “Ice‐Breaking Team” turns an amyotrophic lateral sclerosis patient community into a sustainable ecosystem, realigning philanthropy, data, and research and development to reshape rare‐disease pipelines and guide precision therapies ...
Yang Liu, Xue Xia, Yingfang Chen, Haoying Yang, Xiaochen Chen, Lei Cai, Bingyang Shi   +6 more
wiley   +1 more source

Microengineering the Liver: Strategies for Constructing Functional Liver‐on‐a‐Chip Devices

Exploration, EarlyView.
This review summarizes recent advances in liver‐on‐a‐chip (LOC) technologies, including fabrication strategies and functional integration approaches, and discusses their promising applications in drug screening and related biomedical fields. ABSTRACT Reliable in vitro liver models are indispensable for researching liver diseases and developing ...
Jie Wang, Ziwei Liang, Jiapu Wang, Zongyi Li, Shaojie Wang, Yan Wei, Xin Xie, Di Huang   +7 more
wiley   +1 more source

Brain organoid models of SZT2-related disease reveal an overproduction of outer radial glial cells through mTORC1 activation. [PDF]

Sci Rep
Sato E, Nakamura Y, Fujimoto M, Shimada IS, Iwaki T, Ieda D, Negishi Y, Hattori A, Kato Y, Saitoh S.   +9 more
europepmc   +1 more source