Results 191 to 200 of about 26,410 (296)

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Brain Organoid Transplantation: A Comprehensive Guide to the Latest Advances and Practical Applications-A Systematic Review. [PDF]

Cells
Shen YP, Kokaia Z.
europepmc   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Navigating Brain Organoid Maturation: From Benchmarking Frameworks to Multimodal Bioengineering Strategies. [PDF]

Biomolecules
Huang J, Zhu Y, Tang J, Liu Y, Lu M, Zhang R, Sun AX.   +6 more
europepmc   +1 more source

A Murine Model of Glioblastoma Initiating Cells and Human Brain Organoid Xenograft for Photodynamic Therapy Testing. [PDF]

Int J Mol Sci
Mosteiro A, Diao D, Bedia C, Pedrosa L, Caballero GA, Aldecoa I, Mallo M, Solé F, Sevilla A, Ferrés A, Cabrera G, Muñoz-Tudurí M, Centellas M, Pineda E, Jiménez ÀS, González Sánchez JJ.   +15 more
europepmc   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

Multidisciplinary Strategies for Targeting Tumor Dormancy in Breast Cancer Therapeutics: Hallmarks, Mechanism, and Approaches

iMetaMed, EarlyView.
Clinical phases and classification of breast tumor dormancy. Tumor dormancy is described as the period after treatment until residual tumor cells become detectable as relapsing disease in clinic. During the period of clinical tumor dormancy, tumor mass dormancy and cellular dormancy may coexist.
Shu Chen, Hui Chen, Vijaya Raghavan, Jing Huang, Jin Wang   +4 more
wiley   +1 more source

Organoids: The Future of Medicine [PDF]

, 2019
Kuo, Jonathan
core  

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Transparency and ongoing communication with participants in brain organoid research: Consensus of an interdisciplinary working group. [PDF]

Stem Cell Reports
Cohn B, Doerr M, Feliciano P, Fullerton SM, Hendriks S, Holm S, Hyun I, Jongsma K, Meagher KM, Ross ME, Stein JL, Terry SF, MacDuffie KE.   +12 more
europepmc   +1 more source