Results 201 to 210 of about 551,653 (258)

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Temporal Divergence of True and False Alarms in Pediatric Nocturnal Seizure Monitoring

Annals of Clinical and Translational Neurology, EarlyView.
The early‐morning surge in false seizure alarms supports exploring time‐ or state‐dependent detection thresholds to reduce false detections. ABSTRACT Seizure detection devices can improve the safety of children with epilepsy, yet high false alarms limit their clinical applicability.
Mohammad Shahbakhti, Anemoon T. Bosch, Job van der Palen, Franciscus S. Leijten, Johannes P. van Dijk, Richard H. C. Lazeron, Roland D. Thijs   +6 more
wiley   +1 more source

Subjective Cognitive Concerns and Cognitive Trajectories in Parkinson's Disease: Biomarker Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the relationship of subjective cognitive concerns (SCC) with biomarkers of Alzheimer's disease (AD), neurodegeneration, and Parkinson's disease (PD) and domain‐specific cognitive trajectories among cognitively unimpaired persons with de novo PD. Method Cognitively unimpaired participants with SCC (n = 294) and without SCC (
Francesca V. Lopez, Fareshte Erani, Katherine J. Bangen, David G. Coughlin, Douglas Galasko, Kelsey R. Thomas   +5 more
wiley   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Recent Advances in Intranasal Administration for Brain-Targeting Delivery: A Comprehensive Review of Lipid-Based Nanoparticles and Stimuli-Responsive Gel Formulations. [PDF]

Int J Nanomedicine
Koo J, Lim C, Oh KT.
europepmc   +1 more source

Brain-targeting liposome-based <i>APOE2</i> gene delivery exacerbates soluble amyloid-β accumulation in <i>App</i> ^NL-G-F mice. [PDF]

Heliyon
Wang N, Parsons TM, Ren Y, Pan Y, Kurti A, Starling SC, Muolokwu C, Singh J, Kanekiyo T.   +8 more
europepmc   +1 more source

Biomimetic nanocarriers loaded with temozolomide by cloaking brain-targeting peptides for targeting drug delivery system to promote anticancer effects in glioblastoma cells. [PDF]

Heliyon
Chen H, Wang Y, Wang H, Zhang K, Liu Y, Li Q, Li C, Wen Z, Chen Z.   +8 more
europepmc   +1 more source

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Targeting brain cancer

Science, 2022
A new drug is designed to hit an old target with increased ...
Roger, Reddel, Adel, Aref
openaire   +2 more sources

Pharmaceutical Targeting of the Brain [PDF]

Current Pharmaceutical Design, 2016
Besides being indispensable for the protection and nutrition of the central nervous system (CNS), blood-brain barrier (BBB)-forming cerebral endothelial cells (CECs) have a major role in hampering drugs to reach therapeutically relevant concentrations in the brain.
Krizbai István Adorján, Nyúl-Tóth Ádám, Bauer Hans-Christian, Farkas Elek Attila, Traweger Andreas, Haskó János, Bauer Hannelore, Wilhelm Imola Mária   +7 more
openaire   +3 more sources