Results 211 to 220 of about 551,653 (258)
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Annual Review of Pharmacology and Toxicology, 2007
The central nervous system (CNS) is a sanctuary site and is protected by various barriers. These regulate brain homeostasis and the transport of endogenous and exogenous compounds by controlling their selective and specific uptake, efflux, and metabolism in the brain. Unfortunately, potential drugs for the treatment of most brain diseases are therefore
A G, de Boer, P J, Gaillard
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The central nervous system (CNS) is a sanctuary site and is protected by various barriers. These regulate brain homeostasis and the transport of endogenous and exogenous compounds by controlling their selective and specific uptake, efflux, and metabolism in the brain. Unfortunately, potential drugs for the treatment of most brain diseases are therefore
A G, de Boer, P J, Gaillard
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The brain: A vulnerable target
Experimental Gerontology, 1997This article addresses the description of several endocrine-related functions of the brain. It has emerged that steroids and growth factors may influence brain functions, and that brain cells may metabolize sex steroids. The crosstalk between different types of brain cells (neurons, astrocytes, the LHRH (luteinizing hormone-releasing hormone) producing
L. Martini, R. C. Melcangi
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Targeting the Brain with Nanomedicine
Current Pharmaceutical Design, 2017Herein, we review innovative nanomedicine-based approaches for treating, preventing and diagnosing neurodegenerative diseases. We focus on nanoscale systems such as polymeric nanoparticles (NPs), liposomes, micelles and other vehicles (e.g. dendrimers, nanogels, nanoemulsions and nanosuspensions) for targeted delivery of bioactive molecules to the ...
Rueda, F., Cruz, L.J.
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Targeted therapy for brain tumours
Nature Reviews Drug Discovery, 2004Although previously considered untreatable, brain tumours no longer carry the same prognosis as they did even a decade ago. Recent advances in drug delivery to the central nervous system have not only bypassed physiological constraints such as the blood–brain barrier, but have, in fact, changed the course of treatment for patients with malignant brain ...
Maciej S, Lesniak, Henry, Brem
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Biopharmaceutical drug targeting to the brain
Journal of Drug Targeting, 2010Biopharmaceuticals are large molecule drugs that do not cross the blood-brain barrier (BBB). The limiting factor in the drug development of biopharmaceuticals as new drugs for the human brain is the engineering of effective brain drug targeting technology platforms.
William M Pardridge
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Frontiers in Bioscience, 2004
Activator protein-1 (AP-1) is a transcription factor involved in many aspects of the brain physiology and pathophysiology. In spite of strong engagement in a transcriptional regulation of the brain gene expression, only a few, if any, downstream AP-1 targets have unequivocally been identified so far. In the review we discuss only the best characterized
Marcin, Rylski, Leszek, Kaczmarek
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Activator protein-1 (AP-1) is a transcription factor involved in many aspects of the brain physiology and pathophysiology. In spite of strong engagement in a transcriptional regulation of the brain gene expression, only a few, if any, downstream AP-1 targets have unequivocally been identified so far. In the review we discuss only the best characterized
Marcin, Rylski, Leszek, Kaczmarek
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Targeted Treatment of Brain Metastases
Current Neurology and Neuroscience Reports, 2017Brain metastases are the most common intracranial tumors in adults. Historically, the median survival after the diagnosis of brain metastases has been dismal and medical therapies had a limited role in the management of these patients.The advent of targeted therapy has ushered in an era of increased hope for patients with brain metastases.
Nicole, Shonka +2 more
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Brain Targets for Pain Control
Stereotactic and Functional Neurosurgery, 1998A variety of brain sites have been targeted for surgical treatment of intractable pain. Both ablative and chronic stimulation procedures have been reported to attenuate such pain. These targets include the thalamus and its projections, the periventricular gray, the cingulate cortex and the motor cortex.
K D, Davis +3 more
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Molecular Medicine Today, 1998
Abstract Gene Therapy for Neurological Disorders and Brain Tumors edited by E.A. Chiocca and X.O. Breakefield, Humana Press, 1998.
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Abstract Gene Therapy for Neurological Disorders and Brain Tumors edited by E.A. Chiocca and X.O. Breakefield, Humana Press, 1998.
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Targeting the Gut to Treat the Brain
IEEE Pulse, 2021Only ten years ago, the idea that bacteria in your gut could affect your brain and behavior was seen as a fringe theory. But today, it is well-established that the trillions of microbes in the gastrointestinal tract-collectively known as the gut microbiome-profoundly influence the brain.
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