Results 61 to 70 of about 1,057,184 (299)

Improving Patch-Based Convolutional Neural Networks for MRI Brain Tumor Segmentation by Leveraging Location Information. [PDF]

, 2019
The manual brain tumor annotation process is time consuming and resource consuming, therefore, an automated and accurate brain tumor segmentation tool is greatly in demand. In this paper, we introduce a novel method to integrate location information with
Chen, Jefferson W, Jiang, Jiaxiang, Kao, Po-Yu, Khan, Amil, Manjunath, BS, Shailja, Shailja, Zhang, Angela   +6 more
core  

Protein kinase a distribution differentiates human glioblastoma from brain tissue [PDF]

, 2017
Brain tumor glioblastoma has no clear molecular signature and there is no effective therapy. In rodents, the intracellular distribution of the cyclic AMP (cAMP)-dependent protein kinase (Protein kinase A, PKA) R2Alpha subunit was previously shown to ...
Caretta, Antonio, D\u2019Avella, Domenico, Denaro, Luca, Mucignat-Caretta, Carla   +3 more
core   +2 more sources

Clinical Characteristics and Prognostic Risk Factors for Pediatric B‐Cell Lymphoblastic Lymphoma: A Multicenter Retrospective Cohort Study for China Net Childhood Lymphoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐cell lymphoblastic lymphoma (B‐LBL) represents a rare variety of non‐Hodgkin lymphoma, with limited research on its biology, progression, and management. Methods A retrospective analysis was performed on the clinical characteristics of 256 patients aged ≤18 years who received treatment under the China Net Childhood Lymphoma (CNCL)‐
Zhijuan Liu, Jian Wang, Ling Jin, Yanlong Duan, Fu Li, Yueping Jia, Leping Zhang, Xiaojun Yuan, Wei Liu, Ying Liu, Ansheng Liu, Mincui Zheng, Yunpeng Dai, Lian Jiang, Lirong Sun, Xiaowen Zhai, Rong Liu, Chunju Zhou, Zifen Gao, Yonghong Zhang, Xiaomei Yang   +20 more
wiley   +1 more source

Identification of tumor rejection antigens and the immunologic landscape of medulloblastoma

Genome Medicine
Background The current standard of care treatments for medulloblastoma are insufficient as these do not take tumor heterogeneity into account. Newer, safer, patient-specific treatment approaches are required to treat high-risk medulloblastoma patients ...
Changlin Yang, Vrunda Trivedi, Kyle Dyson, Tongjun Gu, Kate M. Candelario, Oleg Yegorov, Duane A. Mitchell   +6 more
doaj   +1 more source

STING agonist-loaded, CD47/PD-L1-targeting nanoparticles potentiate antitumor immunity and radiotherapy for glioblastoma

Nature Communications, 2023
Glioblastoma is an immunologically cold tumour, with poor CD8 + T cell infiltration and enrichment in immunosuppressive tumour-associated myeloid cells. Here, the authors generate a bispecific lipid nanoparticle targeting CD47 and PD-L1, combined with a ...
Peng Zhang, Aida Rashidi, Junfei Zhao, Caylee Silvers, Hanxiang Wang, Brandyn Castro, Abby Ellingwood, Yu Han, Aurora Lopez-Rosas, Markella Zannikou, Crismita Dmello, Rebecca Levine, Ting Xiao, Alex Cordero, Adam M. Sonabend, Irina V. Balyasnikova, Catalina Lee-Chang, Jason Miska, Maciej S. Lesniak   +18 more
doaj   +1 more source

YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells [PDF]

, 2013
Background: The brain cancer stem cell (CSC) model describes a small subset of glioma cells as being responsible for tumor initiation, conferring therapy resistance and tumor recurrence.
Beier, Dagmar, Girbinger, Vroni, Holm, Per Sonne, Lage, Hermann, Mantwill, Klaus, Mittelbronn, Michel Guy André, Naumann, Ulrike, Schlegel, Jürgen, Seznec, Janina, Surowiak, Pawel   +9 more
core   +1 more source

Brain Tumor Vaccines

Neurosurgery Clinics of North America, 2021
Peptide and dendritic cell vaccines activate the immune system against tumor antigens to combat brain tumors. Vaccines stimulate a systemic immune response by inducing both antitumor T cells as well as humoral immunity through antibody production to cross the blood-brain barrier and combat brain tumors.
Lee, Justin, Uy, Benjamin R, Liau, Linda M   +2 more
openaire   +4 more sources

Exercise Interventions in Children, Adolescents and Young Adults With Paediatric Bone Tumours—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Bone tumours present significant challenges for affected patients, as multimodal therapy often leads to prolonged physical limitations. This is particularly critical during childhood and adolescence, as it can negatively impact physiological development and psychosocial resilience.
Jennifer Queisser, Claire Laurie, Teresa Schmidt, Irene von Luettichau, Peter Bekkering, Sabine Kesting   +5 more
wiley   +1 more source

Brain Tumor Vascular Network Segmentation from Micro-Tomography [PDF]

, 2011
Micro-tomography produces high resolution images of bio- logical structures such as vascular networks. In this paper, we present a new approach for segmenting vascular network into pathological and normal regions from considering their micro-vessel 3D ...
Descombes, Xavier, El Boustani, Abdelhakim, Fonta, Caroline, Leduc, Géraldine, Plouraboué, Franck, Serduc, Raphael, Weitkamp, Timm   +6 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source