Results 101 to 110 of about 158,234 (188)

Inflammation targets specific organs for cancer in carriers of BRCA1/2 pathway mutations [PDF]

, 2010
Women who inherit a defective BRCA1 or BRCA2 gene have risks for breast/ovarian cancer that are so high and apparently so selective that many mutation carriers choose to have the most likely targets for cancer surgically removed.
Bernard Friedenson
core   +1 more source

Male breast cancer [PDF]

, 2017
Male breast cancer (MBC) is a rare disease representing less than 1% of all breast cancers (BC) and less than 1% of cancers in men. Age at presentation is mostly in the late 60s.
A Bjørnerem, A Holleb, A Jemal, AC Antoniou, AM Shaaban, B D'Avanzo, Breast Cancer Linkage Consortium, C Gómez-Raposo, C Martinez-Bouzas, C Rudlowski, D Albo, D Ly, D Palli, DA Rigoni-Stern, DG Evans, DS Popovic, E Kreiter, EF Lewison, G Masci, G Ribeiro, GR Brown, I Ganly, I Sosnovskikh, I Zanna, IS Fentiman, IS Fentinam, J Boyd, J White, JD Fackenthal, JH Breasted, JL Gnerlich, JR Weiss, K Coard, K Syrjakoski, KA Johansen Taber, KD Crew, L France, L Ottini, L Ottini, LA Brinton, LA Brinton, LA Brinton, LA Brinton, LA Brinton, LA Korde, M Falchetti, M Golshan, MA Adank, MB Cook, ME Meijer-van Gelder, MM Munoz de Toro, MT Vietri, N Orr, N Rahman, O Gentilini, P Karamanakos, RM Ferzoco, S Paik, S Peng, S Shak, S Thorlacious, SH Giordano, SH Giordano, SH Giordano, T Grenader, V Silvestri, V Silvestri, V Speirs, WF Anderson, WF Anderson, Y Ge, ZI Mitri   +71 more
core   +1 more source

Efficacy of Next-Generation Sequencing in Identifying Genetic Markers for Prostate Cancer Risk

Journal of Pharmacy and Bioallied Sciences
Background: Prostate cancer is one of the most prevalent cancers among men worldwide. The identification of genetic markers that contribute to the risk of prostate cancer can significantly enhance early diagnosis and personalized treatment strategies ...
Fahad H. Alaithan, Raghad H. Alaithan, Tauheed Ahmed   +2 more
doaj   +1 more source

A family history of breast cancer will not predict female early onset breast cancer in a population-based setting [PDF]

, 2008
: BACKGROUND: An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening.
A Lucassen, A Ziogras, AE Guttmacher, Caroline Seynaeve, Catharina E Jacobi, Cecile TM Brekelmans, Cees J Cornelisse, Christi J van Asperen, CJ Van Asperen, CJ Van Asperen, Collaborative Group on Hormonal Factors in Breast Cancer, D Ford, D Steinmann, D Thompson, DA Berry, DM Eccles, DM Eccles, EB Claus, EB Claus, Elly MM Krol-Warmerdam, FE Harrell Jr, G Parmigiani, Geertruida H de Bock, H Eerola, Jan GM Klijn, Jannet Blom, Johannes C van Houwelingen, JP Klein, KF Hoskins, KL Nathanson, O Visser, PD Pharoah, Peter Devilee, R Gershoni-Baruch, Rob AEM Tollenaar, RW Blamey, The Breast Cancer Linkage Consortium   +36 more
core   +8 more sources

USP3 controls BRCA1 “foci” [PDF]

Cell Cycle, 2013
BRCA1, which is mutated in the familial forms of breast and ovarian cancer, plays important roles in genome stability through its participation in DNA damage response (DDR) following double-stranded breaks (DSBs). BRCA1 activates the checkpoint pathway to retard cell cycle progression and stimulates repair of the DSBs (reviewed in ref. 1).
openaire   +2 more sources

Association Between Germline BRCA1/2 Gene Variants and Clinicopathological Features of Ovarian Cancer

International Journal of General Medicine
Yu Luo,1,2 Ru Pan,1,2 Hui Rao,2,3 Xing Chen,4 Haikun Yang1,2 1Department of Gynaecology, Meizhou People’s Hospital, Meizhou Academy of Medical Sciences, Meizhou, People’s Republic of China; 2Meizhou Municipal Engineering and Technology Research Center ...
Luo Y, Pan R, Rao H, Chen X, Yang H
doaj  

Genetic screening of FFPE breast cancer biopsies for the BRCA1-185delAG mutation in Trinidad and Tobago

Revista Panamericana de Salud Pública
Objective. To investigate whether the quality and quantity of genomic DNA harnessed from existing formalin-fixed paraffin-embedded (FFPE) breast cancer biopsy tissue samples in the public health system of Trinidad and Tobago (T&T) were sufficient for ...
Sheherazade Crystal Abrahim, Dulari Bansraj, Royanne Edwards, Reinand Thompson, Roma Rambaran, Allana Roach, Wayne A. Warner, A. V. Chalapathi Rao, Chandrashekar Unakal, Rajini Rani Haraksingh   +9 more
doaj   +1 more source

Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer. [PDF]

, 2020
Breast cancer is a common cancer that occurs due to different epigenetic alterations and genetic mutations. Various epidemiological studies have demonstrated an inverse correlation between breast cancer incidence and flavonoid intake.
Anwar, Hina, Badgeley, Aja, Lakshmikuttyamma, Ashakumary, Lawrence, Katharine, Murphy, Paige, Selvakumar, Priyanga, Sharma, Urvashi   +6 more
core   +1 more source

Role of the Nrf2/ARE Pathway in the mtDNA Reparation

Frontiers in Bioscience-Landmark
Mitochondrial DNA (mtDNA) is located in the mitochondrial matrix, in close proximity to major sources of reactive oxygen species (ROS) in the cell. This makes mtDNA one of the most susceptible components to damage in the cell.
Artem P. Gureev, Ekaterina V. Chernyshova, Ekaterina P. Krutskikh, Irina S. Sadovnikova, Elena E. Tekutskaya, Anna A. Dorohova   +5 more
doaj   +1 more source

RISK FACTORS OF OVARIAN CANCER AND POSSIBLE PREVENTIVE STRATEGIES

Фундаментальная и клиническая медицина, 2018
Here we review the current data on prevention, diagnosis, and treatment of ovarian cancer, one of the most prevalent genitourinary cancers characterized by high mortality and case fatality rates due to the lack of efficient screening and treatment ...
OLGA B. Karelina, NATALIA V. Artymuk, TATIANA I. Fetisova   +2 more
doaj